Protein Alignment HGTX and NKX2-5

DIOPT Version :10

• Sequence 1: NP_001368954.1
• Gene: HGTX / 53446
• FlyBaseID: FBgn0040318
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_004378.1
• Gene: NKX2-5 / 1482
• HGNCID: 2488
• Length: 324
• Species: Homo sapiens
• Alignment Length: 188
• Identity: 49/188 - (26%)
• Similarity: 85/188 - (45%)
• Gaps: 21/188 - (11%)

  Fly   358 PNPHGIDTILS---KPPPVTSAG-LSALTGAGIPRFSI-------------AAAAAGMAQYLSQS 405
            |.|..:..||:   :...:.:|| |||...|.:...|.             .|||.|:.:..::.
Human     9 PTPFSVKDILNLEQQQRSLAAAGELSARLEATLAPSSCMLAAFKPEAYAGPEAAAPGLPELRAEL 73

  Fly   406 QGAPLKTHAGHIVDRTHLYWPGLQG---LVANPIAWRERLSNTMSA-NLSQSHQHHPSNDKDGKK 466
            ..||..............::|....   ...:|.|.::.|.....| .|.::...:....:..::
Human    74 GRAPSPAKCASAFPAAPAFYPRAYSDPDPAKDPRAEKKELCALQKAVELEKTEADNAERPRARRR 138

  Fly   467 KHTRPTFSGQQIFALEKTFEQTKYLAGPERAKLAYALGMSESQVKVWFQNRRTKWRKR 524
            :..|..||..|::.||:.|:|.:||:.|||.:||..|.::.:|||:||||||.|.:::
Human   139 RKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKRQ 196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	10/33 (30%)
		Homeodomain	465..523	CDD:459649	26/57 (46%)
NKX2-5	NP_004378.1	Homeodomain	145..195	CDD:459649	25/49 (51%)