DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HGTX and Dlx4

DIOPT Version :9

Sequence 1:	NP_001368954.1	Gene:	HGTX / 53446	FlyBaseID:	FBgn0040318	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_031893.3	Gene:	Dlx4 / 13394	MGIID:	94904	Length:	240	Species:	Mus musculus

Alignment Length:	193	Identity:	60/193 - (31%)
Similarity:	92/193 - (47%)	Gaps:	27/193 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   368 SKPPPVTSAGLSALTGAGI-PRFSIAAA---------AAGMAQYLSQSQGAPLK-THAGHIVDRT 421
            |.|.|:...|.|.:....: |..|:.||         ||......|||.|.|.. :|.|......
Mouse     3 SLPCPLPDRGASNVVFPDLAPALSVVAAYPLGLSPGTAASPDLSYSQSYGHPRSYSHPGPATPGD 67

  Fly   422 HLYWPGLQGLVA------NPIAWRERL---SNTMSANLSQSHQHHPSNDKDGKKKHTRPTFSGQQ 477
            . |.|..|.|||      .|....:.|   |..::.:|..|.|...:.    |.:..|..:|..|
Mouse    68 S-YLPRQQQLVAPSQPFHRPAEHPQELEAESEKLALSLVPSQQQSLTR----KLRKPRTIYSSLQ 127

  Fly   478 IFALEKTFEQTKYLAGPERAKLAYALGMSESQVKVWFQNRRTKWRKRHAAEMATAKRKQDDMG 540
            :..|.:.|:.|:|||.||||:||..||::::|||:||||:|:|::|  ..:.::.:.::|..|
Mouse   128 LQHLNQRFQHTQYLALPERAQLAAQLGLTQTQVKIWFQNKRSKYKK--LLKQSSGEPEEDFSG 188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	5/20 (25%)
HGTX	NP_001368954.1	Homeobox	469..523	CDD:395001	26/53 (49%)
Dlx4	NP_031893.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..70		7/26 (27%)
		Homeobox	119..172	CDD:278475	26/52 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	175..194		2/14 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810