DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HGTX and Dlx2

DIOPT Version :9

Sequence 1:	NP_001368954.1	Gene:	HGTX / 53446	FlyBaseID:	FBgn0040318	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_034184.1	Gene:	Dlx2 / 13392	MGIID:	94902	Length:	332	Species:	Mus musculus

Alignment Length:	266	Identity:	70/266 - (26%)
Similarity:	108/266 - (40%)	Gaps:	49/266 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 HSMTTEMKGQGVGGSSASANGLSYSHSPNSHLISDRGSGGSSSSSSTTTTNTNSQGAPNPHGIDT 365
            |.......|.|.||:|.|::..|..|.|            ..|.:...:|.|:|....|
Mouse    26 HQQPPSGAGAGPGGNSNSSSSNSSLHKP------------QESPTLPVSTATDSSYYTN------ 72

  Fly   366 ILSKPPPVTSAGLSALTGAGIPRFSIAAAAAGMAQYLSQSQGAPLKTHAGHIVDRTHLYWPGLQG 430
               :..|....|..|...|.:..:...|:......|.::|     ....|:....|. |.|  .|
Mouse    73 ---QQHPAGGGGGGASPYAHMGSYQYHASGLNNVSYSAKS-----SYDLGYTAAYTS-YAP--YG 126

  Fly   431 LVANPIAWRERLSNTMSANLSQSHQHHPS----NDKDGKKKHTRPTFSGQQIFALEKTFEQTKYL 491
            ..::|:           .|........|.    |.|..|.:..|..:|..|:.||::.|::|:||
Mouse   127 TSSSPV-----------NNEPDKEDLEPEIRIVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYL 180

  Fly   492 AGPERAKLAYALGMSESQVKVWFQNRRTKWRKR-HAAEMATAKRKQDDMGGDNDGDCSETMDSDN 555
            |.||||:||.:||::::|||:||||||:|::|. .:.|:.|    :...|......|:....|..
Mouse   181 ALPERAELAASLGLTQTQVKIWFQNRRSKFKKMWKSGEIPT----EQHPGASASPPCASPPVSAP 241

  Fly   556 ESLDMG 561
            .|.|.|
Mouse   242 ASWDFG 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	19/86 (22%)
HGTX	NP_001368954.1	Homeobox	469..523	CDD:395001	28/53 (53%)
Dlx2	NP_034184.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..83		17/77 (22%)
		DLL_N	54..135	CDD:289198	18/108 (17%)
		Homeobox	158..211	CDD:278475	28/52 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..272		7/33 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	304..332
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810