DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HGTX and Cdx2

DIOPT Version :9

Sequence 1:	NP_001368954.1	Gene:	HGTX / 53446	FlyBaseID:	FBgn0040318	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_031699.2	Gene:	Cdx2 / 12591	MGIID:	88361	Length:	311	Species:	Mus musculus

Alignment Length:	330	Identity:	80/330 - (24%)
Similarity:	118/330 - (35%)	Gaps:	103/330 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 YALSQRSSGAEDPCQTSESASPPPQGQNDYSPENLSSQRAKFQHHHGVNPLALHNANHAGNPGCH 278
            |..|.|.||..:  ...::...||| ..||...::::..|           |..|.:.|.:||
Mouse    14 YPSSVRHSGGLN--LAPQNFVSPPQ-YPDYGGYHVAAAAA-----------ATANLDSAQSPG-- 62

  Fly   279 NNNNHMDHKLPLSFLGPPLAALHSMTTEMKGQGVGGSSAS---ANGLSYSHSPNSHLISDRGSGG 340
                   ...|.:: |.||      ..:..|...||::|:   |:||               :||
Mouse    63 -------PSWPTAY-GAPL------REDWNGYAPGGAAAANAVAHGL---------------NGG 98

  Fly   341 SSSS----SSTTTTNTNSQGAPNPHGIDTILSKPPPVTSAGLSALTGAGIPRFSIAAAAAGMAQY 401
            |.::    ||....:.:.....:||.     ....|..::||......|.|    ..||...|:.
Mouse    99 SPAAAMGYSSPAEYHAHHHPHHHPHH-----PAASPSCASGLLQTLNLGPP----GPAATAAAEQ 154

  Fly   402 LSQSQGAPLKTHAGHIVDRTHLYWPGLQGLVANPIAWRERLSNTMSANLSQSHQHHPSNDKDGKK 466
            ||.|                        |...|...|..:          .:.|...|..|...|
Mouse   155 LSPS------------------------GQRRNLCEWMRK----------PAQQSLGSQVKTRTK 185

  Fly   467 KHTRPTFSGQQIFALEKTFEQTKYLAGPERAKLAYALGMSESQVKVWFQNRRTKWRKRHAAEMAT 531
            ...|..::..|...|||.|..::|:....:::||..||:||.|||:||||||.|.||
Mouse   186 DKYRVVYTDHQRLELEKEFHFSRYITIRRKSELAATLGLSERQVKIWFQNRRAKERK-------- 242

  Fly   532 AKRKQ 536
            .|:||
Mouse   243 IKKKQ 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	38/180 (21%)
HGTX	NP_001368954.1	Homeobox	469..523	CDD:395001	23/53 (43%)
Cdx2	NP_031699.2	Caudal_act	13..170	CDD:282574	48/233 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	111..151		9/48 (19%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:Q99626	185..215		8/29 (28%)
		Homeobox	189..241	CDD:278475	23/51 (45%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000250\|UniProtKB:Q99626	227..241		10/13 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..311		6/17 (35%)
		4S motif, modulates transactivation activity and protein stability. /evidence=ECO:0000269\|PubMed:16027724	281..293
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900