DRSC/TRiP Functional Genomics Resources

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Protein Alignment HGTX and Cdx2

DIOPT Version :10

Sequence 1:NP_001368954.1 Gene:HGTX / 53446 FlyBaseID:FBgn0040318 Length:587 Species:Drosophila melanogaster
Sequence 2:NP_031699.2 Gene:Cdx2 / 12591 MGIID:88361 Length:311 Species:Mus musculus


Alignment Length:330 Identity:80/330 - (24%)
Similarity:118/330 - (35%) Gaps:103/330 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   214 YALSQRSSGAEDPCQTSESASPPPQGQNDYSPENLSSQRAKFQHHHGVNPLALHNANHAGNPGCH 278
            |..|.|.||..:  ...::...||| ..||...::::..|           |..|.:.|.:||  
Mouse    14 YPSSVRHSGGLN--LAPQNFVSPPQ-YPDYGGYHVAAAAA-----------ATANLDSAQSPG-- 62

  Fly   279 NNNNHMDHKLPLSFLGPPLAALHSMTTEMKGQGVGGSSAS---ANGLSYSHSPNSHLISDRGSGG 340
                   ...|.:: |.||      ..:..|...||::|:   |:||               :||
Mouse    63 -------PSWPTAY-GAPL------REDWNGYAPGGAAAANAVAHGL---------------NGG 98

  Fly   341 SSSS----SSTTTTNTNSQGAPNPHGIDTILSKPPPVTSAGLSALTGAGIPRFSIAAAAAGMAQY 401
            |.::    ||....:.:.....:||.     ....|..::||......|.|    ..||...|:.
Mouse    99 SPAAAMGYSSPAEYHAHHHPHHHPHH-----PAASPSCASGLLQTLNLGPP----GPAATAAAEQ 154

  Fly   402 LSQSQGAPLKTHAGHIVDRTHLYWPGLQGLVANPIAWRERLSNTMSANLSQSHQHHPSNDKDGKK 466
            ||.|                        |...|...|..:          .:.|...|..|...|
Mouse   155 LSPS------------------------GQRRNLCEWMRK----------PAQQSLGSQVKTRTK 185

  Fly   467 KHTRPTFSGQQIFALEKTFEQTKYLAGPERAKLAYALGMSESQVKVWFQNRRTKWRKRHAAEMAT 531
            ...|..::..|...|||.|..::|:....:::||..||:||.|||:||||||.|.||        
Mouse   186 DKYRVVYTDHQRLELEKEFHFSRYITIRRKSELAATLGLSERQVKIWFQNRRAKERK-------- 242

  Fly   532 AKRKQ 536
            .|:||
Mouse   243 IKKKQ 247

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HGTXNP_001368954.1 ROM1 179..>388 CDD:227709 38/180 (21%)
Homeodomain 465..523 CDD:459649 24/57 (42%)
Cdx2NP_031699.2 Caudal_act 13..178 CDD:461413 49/251 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 111..151 9/48 (19%)
Interaction with DNA. /evidence=ECO:0000250|UniProtKB:Q99626 185..215 8/29 (28%)
Homeodomain 187..242 CDD:459649 23/54 (43%)
Interaction with 5-mCpG DNA. /evidence=ECO:0000250|UniProtKB:Q99626 227..241 10/13 (77%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..311 6/17 (35%)
4S motif, modulates transactivation activity and protein stability. /evidence=ECO:0000269|PubMed:16027724 281..293
Blue background indicates that the domain is not in the aligned region.

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