DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HGTX and Cdx1

DIOPT Version :9

Sequence 1:	NP_001368954.1	Gene:	HGTX / 53446	FlyBaseID:	FBgn0040318	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_034010.3	Gene:	Cdx1 / 12590	MGIID:	88360	Length:	268	Species:	Mus musculus

Alignment Length:	169	Identity:	52/169 - (30%)
Similarity:	68/169 - (40%)	Gaps:	31/169 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 PPPVTSAGLSALTGAG-IPRFSIAAAAAGMAQ-YLSQSQGAPLKTHAGHIVDRTHLYWPGLQGLV 432
            |.|..||...|....| .|.||...|..|... .|:||.|||....:.....||
Mouse    78 PGPTASAASPAPLAFGPPPDFSPVPAPPGPGPGILAQSLGAPGAPSSPGAPRRT----------- 131

  Fly   433 ANPIAWRERLSNTMSANLSQSHQHHPSNDKDGKKKHTRPTFSGQQIFALEKTFEQTKYLAGPERA 497
              |..|..|         |.:......:.|...|...|..::..|...|||.|..::|:....::
Mouse   132 --PYEWMRR---------SVAAAGGGGSGKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKS 185

  Fly   498 KLAYALGMSESQVKVWFQNRRTKWRKRHAAEMATAKRKQ 536
            :||..||::|.|||:||||||.|.||       ..|:||
Mouse   186 ELAANLGLTERQVKIWFQNRRAKERK-------VNKKKQ 217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	6/18 (33%)
HGTX	NP_001368954.1	Homeobox	469..523	CDD:395001	22/53 (42%)
Cdx1	NP_034010.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..152		24/95 (25%)
		Caudal_act	13..138	CDD:282574	21/72 (29%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P47902	157..178		6/20 (30%)
		Homeobox	158..210	CDD:278475	22/51 (43%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000250\|UniProtKB:P47902	196..207		8/10 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..268		5/16 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900