DRSC/TRiP Functional Genomics Resources

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Protein Alignment HGTX and CDX1

DIOPT Version :9

Sequence 1:NP_001368954.1 Gene:HGTX / 53446 FlyBaseID:FBgn0040318 Length:587 Species:Drosophila melanogaster
Sequence 2:NP_001795.2 Gene:CDX1 / 1044 HGNCID:1805 Length:265 Species:Homo sapiens


Alignment Length:224 Identity:58/224 - (25%)
Similarity:82/224 - (36%) Gaps:40/224 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   356 GAPNPHGID---TILSKPPPVTSAGLSALTGAGIPRFSIAAAAAGMAQ-YLSQSQGAPLKTHAGH 416
            |||.|...|   ......|...:|..::|.....|.||...|..|... .|:|..|.|....:  
Human    62 GAPFPAPKDDWAAAYGPGPAAPAASPASLAFGPPPDFSPVPAPPGPGPGLLAQPLGGPGTPSS-- 124

  Fly   417 IVDRTHLYWPGLQGLVANPIAWRERLSNTMSANLSQSHQHHPSNDKDGKKKHTRPTFSGQQIFAL 481
                     ||.|.  ..|..|..|         |.:......:.|...|...|..::..|...|
Human   125 ---------PGAQR--PTPYEWMRR---------SVAAGGGGGSGKTRTKDKYRVVYTDHQRLEL 169

  Fly   482 EKTFEQTKYLAGPERAKLAYALGMSESQVKVWFQNRRTKWRKRHAAEMATAKRKQDDMGGDNDGD 546
            ||.|..::|:....:::||..||::|.|||:||||||.|.||.:..:....:..|..|..|....
Human   170 EKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQPPQPPMAHDITAT 234

  Fly   547 CSETMDSDNESLDMGESPAQNKRCRSNSS 575
            .:              .|:....|.||:|
Human   235 PA--------------GPSLGGLCPSNTS 249

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HGTXNP_001368954.1 ROM1 179..>388 CDD:227709 8/34 (24%)
Homeobox 469..523 CDD:395001 22/53 (42%)
CDX1NP_001795.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 9..153 25/112 (22%)
Caudal_act 13..138 CDD:282574 22/88 (25%)
Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536 157..178 6/20 (30%)
Homeobox 158..210 CDD:278475 22/51 (43%)
Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536 196..207 8/10 (80%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 207..265 11/57 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0850
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X14
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.900

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