Protein Alignment SC35 and EIF4H

DIOPT Version :10

• Sequence 1: NP_652612.1
• Gene: SC35 / 53444
• FlyBaseID: FBgn0265298
• Length: 195
• Species: Drosophila melanogaster
• Sequence 2: NP_071496.1
• Gene: EIF4H / 7458
• HGNCID: 12741
• Length: 248
• Species: Homo sapiens
• Alignment Length: 210
• Identity: 57/210 - (27%)
• Similarity: 78/210 - (37%)
• Gaps: 51/210 - (24%)

  Fly     2 SNGGGAGGLGAA-------------RPPPRIDGMVSLKVDNLTYRTTPEDLRRVFERCGEVGDIY 53
            |.|||.|..|:|             .||      .:..|.||.:.|...|:..:|:.. .:..:.
Human    14 SFGGGRGSRGSAGGHGSRSQKELPTEPP------YTAYVGNLPFNTVQGDIDAIFKDL-SIRSVR 71

  Fly    54 IPRDRYTRESRGFAFVRFYDKRDAEDALEAMDGRMLDGRELRVQMA------------RYGRPSS 106
            :.||:.|.:.:||.:|.|.:....::|| ..||.:|..|.|||.:|            |.|.|..
Human    72 LVRDKDTDKFKGFCYVEFDEVDSLKEAL-TYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDD 135

  Fly   107 PTRSSSGR-RGG----------------GGGGGS-GGRRRSRSRSPMRRRSRSPRRRSYSRSRSP 153
            ....||.. |||                ||.||| .|.||:......|.|...|.|.|....|.|
Human   136 RGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREP 200

  Fly   154 GSHSPERRSKFSRSP 168
            ......:|.:....|
Human   201 TEEERAQRPRLQLKP 215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SC35	NP_652612.1	RRM_SRSF2_SRSF8	25..97	CDD:409751	21/71 (30%)
EIF4H	NP_071496.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		7/26 (27%)
		RRM_eIF4H	37..120	CDD:409835	25/90 (28%)
		SF-CC1	<40..>227	CDD:273721	50/184 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..248		25/95 (26%)
		HHV-1 Vhs binding site	137..157		5/19 (26%)