DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SC35 and Srsf2

DIOPT Version :9

Sequence 1:	NP_001188794.1	Gene:	SC35 / 53444	FlyBaseID:	FBgn0265298	Length:	195	Species:	Drosophila melanogaster
Sequence 2:	NP_001009720.1	Gene:	Srsf2 / 494445	RGDID:	1359422	Length:	221	Species:	Rattus norvegicus

Alignment Length:	189	Identity:	116/189 - (61%)
Similarity:	134/189 - (70%)	Gaps:	13/189 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RPPPRIDGMVSLKVDNLTYRTTPEDLRRVFERCGEVGDIYIPRDRYTRESRGFAFVRFYDKRDAE 78
            ||||.::||.|||||||||||:|:.||||||:.|.|||:||||||||:||||||||||:||||||
  Rat     5 RPPPDVEGMTSLKVDNLTYRTSPDTLRRVFEKYGRVGDVYIPRDRYTKESRGFAFVRFHDKRDAE 69

  Fly    79 DALEAMDGRMLDGRELRVQMARYGRPSSPTRSSSG---RRGGGGGGG---SGGRRRSRSRSPMRR 137
            ||::||||.:||||||||||||||||.....|..|   ||.||||.|   ...|||.||||..|.
  Rat    70 DAMDAMDGAVLDGRELRVQMARYGRPPDSHHSRRGPPPRRYGGGGYGRRSRSPRRRRRSRSRSRS 134

  Fly   138 RSRSPRRRSYSRSRSPG-SHSPERRSKFSRSPVRGDSRNGIGSGSGGLAPAASRSRSRS 195
            ||||..|..||||:|.. :.|..|.:..|||..|..|:      |..::.:.|||||||
  Rat   135 RSRSRSRSRYSRSKSRSRTRSRSRSTSKSRSARRSKSK------SSSVSRSRSRSRSRS 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SC35	NP_001188794.1	RRM	<24..>100	CDD:223796	62/75 (83%)
SC35	NP_001188794.1	RRM_SRSF2_SRSF8	25..97	CDD:240757	58/71 (82%)
Srsf2	NP_001009720.1	RRM_SRSF2_SRSF8	16..88	CDD:409751	58/71 (82%)
Srsf2	NP_001009720.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..221		46/102 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345941
Domainoid	1	1.000	125	1.000	Domainoid score	I5348
eggNOG	1	0.900	-	-		E1_KOG4207
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	206	1.000	Inparanoid score	I3644
OMA	1	1.010	-	-		QHG51897
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003650
OrthoInspector	1	1.000	-	-		oto96035
orthoMCL	1	0.900	-	-		OOG6_104633
Panther	1	1.100	-	-	LDO	PTHR23147
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3014
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800