DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SC35 and srsf2a

DIOPT Version :9

Sequence 1:	NP_001188794.1	Gene:	SC35 / 53444	FlyBaseID:	FBgn0265298	Length:	195	Species:	Drosophila melanogaster
Sequence 2:	NP_998547.1	Gene:	srsf2a / 406691	ZFINID:	ZDB-GENE-040426-2706	Length:	225	Species:	Danio rerio

Alignment Length:	188	Identity:	119/188 - (63%)
Similarity:	135/188 - (71%)	Gaps:	13/188 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RPPPRIDGMVSLKVDNLTYRTTPEDLRRVFERCGEVGDIYIPRDRYTRESRGFAFVRFYDKRDAE 78
            ||||.::||.|||||||||||:||.||||||:.|.|||:||||||||:||||||||||:||||||
Zfish     5 RPPPDVEGMTSLKVDNLTYRTSPETLRRVFEKYGRVGDVYIPRDRYTKESRGFAFVRFHDKRDAE 69

  Fly    79 DALEAMDGRMLDGRELRVQMARYGRPSSPTRSSSG---RRGGGGGGGSGGRRRSRSRSPMRR--- 137
            ||::||||.:||||||||||||||||.....|..|   ||.||.|      ||||||||.||
Zfish    70 DAMDAMDGALLDGRELRVQMARYGRPPDAHYSRRGAPPRRYGGYG------RRSRSRSPRRRKHS 128

  Fly   138 RSRSPRRRSYSRSRSPGSHSPERRSKFSRSPVRGDSRNGIGSGSGGLAPAASRSRSRS 195
            |||| |.||.|||||...:|..|...:|||..|..||:...:.....:.:.|||||||
Zfish   129 RSRS-RSRSRSRSRSRSRYSRSRSRSYSRSRSRSRSRSKTRTPRRSKSKSPSRSRSRS 185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SC35	NP_001188794.1	RRM	<24..>100	CDD:223796	63/75 (84%)
SC35	NP_001188794.1	RRM_SRSF2_SRSF8	25..97	CDD:240757	59/71 (83%)
srsf2a	NP_998547.1	RRM	<5..>91	CDD:223796	69/85 (81%)
srsf2a	NP_998547.1	RRM_SRSF2_SRSF8	16..88	CDD:240757	59/71 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586922
Domainoid	1	1.000	126	1.000	Domainoid score	I5354
eggNOG	1	0.900	-	-		E1_KOG4207
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	208	1.000	Inparanoid score	I3665
OMA	1	1.010	-	-		QHG51897
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003650
OrthoInspector	1	1.000	-	-		otm26387
orthoMCL	1	0.900	-	-		OOG6_104633
Panther	1	1.100	-	-	LDO	PTHR23147
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1169
SonicParanoid	1	1.000	-	-		X3014
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790