DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SC35 and RNPS1

DIOPT Version :9

Sequence 1:	NP_001188794.1	Gene:	SC35 / 53444	FlyBaseID:	FBgn0265298	Length:	195	Species:	Drosophila melanogaster
Sequence 2:	NP_001273554.1	Gene:	RNPS1 / 10921	HGNCID:	10080	Length:	305	Species:	Homo sapiens

Alignment Length:	164	Identity:	59/164 - (35%)
Similarity:	81/164 - (49%)	Gaps:	31/164 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PPPRIDGMVSLKVDNLTYRTTPEDLRRVFERCGEVGDIYIPRDR-YTRESRGFAFVRFYDKRDAE 78
            |.|:   ...:.:..||...|.:.:..:|...|::..|.:|.:| :...|:|:|:|.|.:..:||
Human   156 PSPK---PTKVHIGRLTRNVTKDHIMEIFSTYGKIKMIDMPVERMHPHLSKGYAYVEFENPDEAE 217

  Fly    79 DALEAMDGRMLDGRELRVQ--MARYGRPSSPTRSSSGRR--------GGGGGGGSGGRRRSRSRS 133
            .||:.|||..:||:|:...  :|.:.|| .|.|.|..||                   |||..|
Human   218 KALKHMDGGQIDGQEITATAVLAPWPRP-PPRRFSPPRRMLPPPPMW-----------RRSPPR- 269

  Fly   134 PMRRRSRSPRRRSYSRSRSPGSHSPERRSKFSRS 167
             ||||||||||||..|.|   |.||.||...|||
Human   270 -MRRRSRSPRRRSPVRRR---SRSPGRRRHRSRS 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SC35	NP_001188794.1	RRM	<24..>100	CDD:223796	23/78 (29%)
SC35	NP_001188794.1	RRM_SRSF2_SRSF8	25..97	CDD:240757	23/72 (32%)
RNPS1	NP_001273554.1	Necessary for interaction with the cleaved p110 isoform of CDC2L1	1..220		17/66 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..170		3/16 (19%)
		Necessary for interaction with SRP54, nuclear localization and exon-skipping. /evidence=ECO:0000269\|PubMed:14729963	1..161		2/7 (29%)
		Necessary for interactions with UPF2 and UPF3B and UPF2-dependent NMD	69..121
		Necessary for interaction with PNN and exon-skipping	156..242		26/88 (30%)
		Interaction with SAP18 and ACIN1. /evidence=ECO:0000269\|PubMed:20966198	159..244		24/87 (28%)
		RRM_RNPS1	163..236	CDD:409800	23/72 (32%)
		Necessary for interaction with TRA2B, nuclear localization and exon-skipping. /evidence=ECO:0000269\|PubMed:14729963	238..305		34/79 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..305		34/77 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1169
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030