DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SF2 and GBP2

DIOPT Version :9

Sequence 1:	NP_001247139.1	Gene:	SF2 / 53443	FlyBaseID:	FBgn0283477	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	NP_009916.1	Gene:	GBP2 / 850346	SGDID:	S000000517	Length:	427	Species:	Saccharomyces cerevisiae

Alignment Length:	300	Identity:	69/300 - (23%)
Similarity:	101/300 - (33%)	Gaps:	94/300 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RN-ECRIYVGNLPPDIRTKDIQDLFHKFGKVTFVDLKNRRG--PPFAFVEFEDARDADDAVKARD 65
            || |..|:|.||..|...:|:::||...|:|...|:...:|  .....|||.......||:...|
Yeast   118 RNFENSIFVRNLTFDCTPEDLKELFGTVGEVVEADIITSKGHHRGMGTVEFTKNESVQDAISKFD 182

  Fly    66 GYDYDGYRLRVEFPRGGGPGSYRGGNRNDRSRDGGGRMGGRGPPAKRSQ--------------YR 116
            |..:...:|.|               |.|            .||.:.::              :.
Yeast   183 GALFMDRKLMV---------------RQD------------NPPPEAAKEFSKKATREEIDNGFE 220

  Fly   117 VMVTGLPASGSWQDLKDHMREAGDVCFADTYKD------GSGVVEFLRHEDMKYAIK-------- 167
            |.:..||.|.:||.|||..:|.|.|..||...|      |.|.|.:...::|..||.
Yeast   221 VFIINLPYSMNWQSLKDMFKECGHVLRADVELDFNGFSRGFGSVIYPTEDEMIRAIDTFNGMEVE 285

  Fly   168 ----KLDDSRFRSHEGEVAYIRVREDSGDNDRGGGGGGSGGGG-----------GGSGGGGSRDY 217
                ::.:.||...:....|.:.|||..|. ||...|.:....           .|...||.|:.
Yeast   286 GRVLEVREGRFNKRKNNDRYNQRREDLEDT-RGTEPGLAQDAAVHIDETAAKFTEGVNPGGDRNC 349

  Fly   218 RDRSRSRSFSS--------------------RPRRRGTPT 237
            .....:..||:                    :|:..|.||
Yeast   350 FIYCSNLPFSTARSDLFDLFGPIGKINNAELKPQENGQPT 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SF2	NP_001247139.1	RRM_SF	3..80	CDD:418427	24/78 (31%)
SF2	NP_001247139.1	RRM2_SRSF1_like	115..188	CDD:410013	24/90 (27%)
GBP2	NP_009916.1	RRM1_HRB1_GBP2	121..197	CDD:410184	24/102 (24%)
		RRM2_HRB1_GBP2	218..292	CDD:410185	21/73 (29%)
		RRM3_HRB1_GBP2	347..425	CDD:410186	6/42 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1173
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860