DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SF2 and TIAL1

DIOPT Version :9

Sequence 1:	NP_001247139.1	Gene:	SF2 / 53443	FlyBaseID:	FBgn0283477	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	NP_001029097.1	Gene:	TIAL1 / 7073	HGNCID:	11804	Length:	392	Species:	Homo sapiens

Alignment Length:	202	Identity:	46/202 - (22%)
Similarity:	74/202 - (36%)	Gaps:	57/202 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NECRIYVGNLPPDIRTKDIQDLFHKFGKVT----FVDLKNRRGPPFAFVEFEDARDADDAVKARD 65
            |...::||:|.|:|.|:||:..|..|||::    ..|:...:...:.||.|.:..||::|:....
Human   112 NHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMG 176

  Fly    66 GYDYDGYRLRVEFPRGGGPGSYRGGNRNDRSRDGGGRMGGRGPPAKRS-------QYR------- 116
            |....|.::|..:                         ..|.|||.:|       |.|
Human   177 GQWLGGRQIRTNW-------------------------ATRKPPAPKSTQENNTKQLRFEDVVNQ 216

  Fly   117 ------VMVTGLPASGSWQDLKDHMREA----GDVCFADTYKD-GSGVVEFLRHEDMKYAIKKLD 170
                  .:..|..|||....|   ||:.    |.:.....:.: |...|.|..||...:||..::
Human   217 SSPKNCTVYCGGIASGLTDQL---MRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVN 278

  Fly   171 DSRFRSH 177
            .:....|
Human   279 GTTIEGH 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SF2	NP_001247139.1	RRM_SF	3..80	CDD:418427	23/78 (29%)
SF2	NP_001247139.1	RRM2_SRSF1_like	115..188	CDD:410013	17/81 (21%)
TIAL1	NP_001029097.1	RRM1_TIAR	10..107	CDD:410028
		RRM2_TIAR	113..192	CDD:410029	22/103 (21%)
		RRM3_TIAR	222..294	CDD:241064	16/67 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810