Protein Alignment SF2 and SNRNP70

DIOPT Version :10

• Sequence 1: NP_652611.1
• Gene: SF2 / 53443
• FlyBaseID: FBgn0283477
• Length: 255
• Species: Drosophila melanogaster
• Sequence 2: NP_003080.2
• Gene: SNRNP70 / 6625
• HGNCID: 11150
• Length: 437
• Species: Homo sapiens
• Alignment Length: 303
• Identity: 74/303 - (24%)
• Similarity: 97/303 - (32%)
• Gaps: 92/303 - (30%)

  Fly     9 IYVGNLPPDIRTKDIQDLFHKFGKVTFVDL--KNRRGPP--FAFVEFEDARDADDAVKARDGYDY 69
            ::|..:..|.....::..|..:|.:..:.:  ..|.|.|  :||:|:|..||...|.|..||...
Human   105 LFVARVNYDTTESKLRREFEVYGPIKRIHMVYSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKI 169

  Fly    70 DGYRLRVEFPR------------GGG-PGSYRGG---NRNDRSRDGGGRMGGRGPPAKRSQYRVM 118
            ||.|:.|:..|            ||| .|:.|||   |.....||...|...|..|:.
Human   170 DGRRVLVDVERGRTVKGWRPRRLGGGLGGTRRGGADVNIRHSGRDDTSRYDERPGPSP------- 227

  Fly   119 VTGLPASGSWQDLKDHMREAGDVCFADTYKDGSGVVEFLRHEDMKYAIKKLDDSRFRSHEGEVAY 183
               ||.....:|.:...||      ....:|........|..|.:...:..|....|
Human   228 ---LPHRDRDRDRERERRE------RSRERDKERERRRSRSRDRRRRSRSRDKEERR-------- 275

  Fly   184 IRVREDSGDND------------------------RGGGG--------------GGSGGGGGGSG 210
             |.||.|.|.|                        |||||              .|..|..|..|
Human   276 -RSRERSKDKDRDRKRRSSRSRERARRERERKEELRGGGGDMAEPSEAGDAPPDDGPPGELGPDG 339

  Fly   211 GGGSRDY-RDRSRSRSFSSRPRRRGTPTYSPVRRQSYSRSRSR 252
            ..|..:. |||.|.|..|.|..|.        ||:...|.|.|
Human   340 PDGPEEKGRDRDRERRRSHRSERE--------RRRDRDRDRDR 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SF2	NP_652611.1	RRM_SF	3..80	CDD:473069	21/74 (28%)
		RRM2_SRSF1_like	115..188	CDD:410013	11/72 (15%)
SNRNP70	NP_003080.2	U1snRNP70_N	3..94	CDD:432406
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	48..79
		Required for interaction with U1 RNA. /evidence=ECO:0000269|PubMed:2467746	92..202		26/96 (27%)
		RRM_snRNP70	102..187	CDD:409682	22/81 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	187..437		52/221 (24%)