Protein Alignment SF2 and SRSF4

DIOPT Version :10

• Sequence 1: NP_652611.1
• Gene: SF2 / 53443
• FlyBaseID: FBgn0283477
• Length: 255
• Species: Drosophila melanogaster
• Sequence 2: NP_005617.2
• Gene: SRSF4 / 6429
• HGNCID: 10786
• Length: 494
• Species: Homo sapiens
• Alignment Length: 276
• Identity: 109/276 - (39%)
• Similarity: 140/276 - (50%)
• Gaps: 49/276 - (17%)

  Fly     8 RIYVGNLPPDIRTKDIQDLFHKFGKVTFVDLKNRRGPPFAFVEFEDARDADDAVKARDGYDYDGY 72
            |:|:|.|....|.:|::..|..:||:..|||||..|    ||||:|.|||||||...:|.|..|.
Human     3 RVYIGRLSYQARERDVERFFKGYGKILEVDLKNGYG----FVEFDDLRDADDAVYELNGKDLCGE 63

  Fly    73 RLRVEFPRGGGP---GSYRGGNRNDRSRDG-GGRMGGR---GPPAKRSQYRVMVTGLPASGSWQD 130
            |:.||..|  ||   |||..|      |.| |.|..||   |||. |::||::|..|.:..||||
Human    64 RVIVEHAR--GPRRDGSYGSG------RSGYGYRRSGRDKYGPPT-RTEYRLIVENLSSRCSWQD 119

  Fly   131 LKDHMREAGDVCFADTYK--DGSGVVEFLRHEDMKYAIKKLDD---------------------- 171
            |||:||:||:|.:||.:|  ...||:||:.:.|||.|::|||.
Human   120 LKDYMRQAGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRS 184

  Fly   172 -SRFRSHEGEVAYIRVREDSGDNDRGGGGGGSGGGGGGSGGGGSRDYRDRSRSRSFSSRPRRRGT 235
             ||.|||....:  |.|.......|.|....|..........|||. |.:||||| .||.|.:..
Human   185 YSRSRSHSRSRS--RSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRS-RSKSRSRS-QSRSRSKKE 245

  Fly   236 PTYSPVRRQSYSRSRS 251
            .:.||.:.:|.|||.|
Human   246 KSRSPSKEKSRSRSHS 261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SF2	NP_652611.1	RRM_SF	3..80	CDD:473069	33/71 (46%)
		RRM2_SRSF1_like	115..188	CDD:410013	36/97 (37%)
SRSF4	NP_005617.2	RRM1_SRSF4	1..87	CDD:410007	42/95 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	72..95		12/28 (43%)
		RRM2_SRSF4_like	104..175	CDD:410012	30/70 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..494		29/97 (30%)