DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SF2 and Snrnp70

DIOPT Version :9

Sequence 1:	NP_001247139.1	Gene:	SF2 / 53443	FlyBaseID:	FBgn0283477	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	XP_006229163.1	Gene:	Snrnp70 / 361574	RGDID:	1307120	Length:	451	Species:	Rattus norvegicus

Alignment Length:	321	Identity:	83/321 - (25%)
Similarity:	106/321 - (33%)	Gaps:	109/321 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IYVGNLPPDIRTKDIQDLFHKFGKVTFVDL--KNRRGPP--FAFVEFEDARDADDAVKARDGYDY 69
            ::|..:..|.....::..|..:|.:..:.:  ..|.|.|  :||:|:|..||...|.|..||...
  Rat   105 LFVARVNYDTTESKLRREFEVYGPIKRIHMVYSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKI 169

  Fly    70 DGYRLRVEFPR------------GGG-PGSYRGG---NRNDRSRDGGGRMGGRGPPAKRSQYRVM 118
            ||.|:.|:..|            ||| .|:.|||   |.....||...|...|..|:.
  Rat   170 DGRRVLVDVERGRTVKGWRPRRLGGGLGGTRRGGADVNIRHSGRDDTSRYDERPGPSP------- 227

  Fly   119 VTGLPASGSWQDLKDHMREAGDVCFADTYKDGSGVVEFLRHEDMKYAIKKLD-DSRFRSHEGEVA 182
               ||.....:|.:...||      ....:|........|..|.:...:..| |.|.||
  Rat   228 ---LPHRDRDRDRERERRE------RSRERDKERERRRSRSRDRRRRSRSRDKDERRRS------ 277

  Fly   183 YIRVREDSGDNDR-------------------------GGGGGGSGGGGGGSGGGG--------- 213
                ||.|.|.||                         ||||||.||||||.||||
  Rat   278 ----RERSKDKDRDRKRRSSRSRERARRERERKEELRGGGGGGGGGGGGGGGGGGGDMAEPSEAG 338

  Fly   214 --------------------SRDYRDRSRSRSFSSRPRRRGTPTYSPVRRQSYSRSRSRSN 254
                                ....|||.|.|..|.|..|.        ||:...|.|.|.:
  Rat   339 DGAPDDGPPGELGPEGPDGPEEKGRDRDRERRRSHRSERE--------RRRDRDRDRDREH 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SF2	NP_001247139.1	RRM_SF	3..80	CDD:418427	21/74 (28%)
SF2	NP_001247139.1	RRM2_SRSF1_like	115..188	CDD:410013	13/73 (18%)
Snrnp70	XP_006229163.1	U1snRNP70_N	2..93	CDD:289024
		RRM	26..>182	CDD:223796	22/76 (29%)
		RRM_snRNP70	102..187	CDD:240682	22/81 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900