DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SF2 and CSTF2T

DIOPT Version :9

Sequence 1:	NP_001247139.1	Gene:	SF2 / 53443	FlyBaseID:	FBgn0283477	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	NP_056050.1	Gene:	CSTF2T / 23283	HGNCID:	17086	Length:	616	Species:	Homo sapiens

Alignment Length:	177	Identity:	38/177 - (21%)
Similarity:	73/177 - (41%)	Gaps:	41/177 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IYVGNLPPDIRTKDIQDLFHKFGKVTFVDLKNRR--GPP--FAFVEFEDARDADDAVKARDGYDY 69
            ::|||:|.:...:.::|:|.:.|.|....|...|  |.|  :.|.|::|...|..|::..:|.::
Human    18 VFVGNIPYEATEEQLKDIFSEVGSVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREF 82

  Fly    70 DGYRLRVEFPRGGGPGSYRGGNRNDRSRDGGGRMGGRGP--PAKRSQY-------------RVMV 119
            .|..|||:               |..|......:...||  |...|.|             ...|
Human    83 SGRALRVD---------------NAASEKNKEELKSLGPAAPIIDSPYGDPIDPEDAPESITRAV 132

  Fly   120 TGLPASGSWQDLKDHMREAGDVCFADTYKDGSGVVEFLRHEDMKYAI 166
            ..||....::.:| .|:    :|..:::::...::  |::..:.||:
Human   133 ASLPPEQMFELMK-QMK----LCVQNSHQEARNML--LQNPQLAYAL 172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SF2	NP_001247139.1	RRM_SF	3..80	CDD:418427	22/74 (30%)
SF2	NP_001247139.1	RRM2_SRSF1_like	115..188	CDD:410013	10/65 (15%)
CSTF2T	NP_056050.1	RRM	<16..>109	CDD:223796	26/105 (25%)
		RRM_CSTF2_CSTF2T	18..92	CDD:241115	22/88 (25%)
		CSTF2_hinge	113..191	CDD:291025	11/67 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..418
		9 X 5 AA tandem repeats of M-E-T-R-[AG]	418..462
		9 X 5 AA tandem repeats of G-[AT]-G-[MI]-Q	505..549
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..573
		CSTF_C	572..612	CDD:291002
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900