Protein Alignment SF2 and SRSF12

DIOPT Version :10

• Sequence 1: NP_652611.1
• Gene: SF2 / 53443
• FlyBaseID: FBgn0283477
• Length: 255
• Species: Drosophila melanogaster
• Sequence 2: NP_542781.3
• Gene: SRSF12 / 135295
• HGNCID: 21220
• Length: 261
• Species: Homo sapiens
• Alignment Length: 257
• Identity: 65/257 - (25%)
• Similarity: 108/257 - (42%)
• Gaps: 66/257 - (25%)

  Fly     9 IYVGNLPPDIRTKDIQDLFHKFGKVTFV----DLKNRRGPPFAFVEFEDARDADDAVKARDGYDY 69
            :::.|:....|.:|::..|.::|.:..|    |...||...||:|:|||.|||:||:     |:.
Human    12 LFIRNVADATRPEDLRREFGRYGPIVDVYIPLDFYTRRPRGFAYVQFEDVRDAEDAL-----YNL 71

  Fly    70 D-----GYRLRVEFPRGG--GPGSYRGGNRNDRSRDGGGRMGGRGPPAKRSQYRVMVTGLPASGS 127
            :     |.::.::|.:|.  .||..:...|:..|.....|  .|.|..:|::.|        |.|
Human    72 NRKWVCGRQIEIQFAQGDRKTPGQMKSKERHPCSPSDHRR--SRSPSQRRTRSR--------SSS 126

  Fly   128 WQDLKDHMREAGDVCFADTYKDGSGVVEFLRHEDMKYAIKKLDDSRFRSHEGEVAYIRVREDSGD 192
            |.  ::..|       :|:.|:.       ||....|:..|   ||.:|       :..|..|..
Human   127 WG--RNRRR-------SDSLKES-------RHRRFSYSQSK---SRSKS-------LPRRSTSAR 165

  Fly   193 NDRGGGGGGSGGGGGGSGGGGSRDYRDRSRSRSFSSRPRRRGTPTYSPVRRQSYSRSRSRSN 254
            ..|      :.....||        |.||||:|...|.:..|....|..::|:.|.::|||:
Human   166 QSR------TPRRNFGS--------RGRSRSKSLQKRSKSIGKSQSSSPQKQTSSGTKSRSH 213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SF2	NP_652611.1	RRM_SF	3..80	CDD:473069	23/79 (29%)
		RRM2_SRSF1_like	115..188	CDD:410013	14/72 (19%)
SRSF12	NP_542781.3	RRM_SRSF10_SRSF12	10..93	CDD:240758	24/85 (28%)
		PABP-1234	<12..211	CDD:130689	62/253 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	86..261		42/178 (24%)