Protein Alignment SF2 and RBM7

DIOPT Version :10

• Sequence 1: NP_652611.1
• Gene: SF2 / 53443
• FlyBaseID: FBgn0283477
• Length: 255
• Species: Drosophila melanogaster
• Sequence 2: NP_001272974.1
• Gene: RBM7 / 10179
• HGNCID: 9904
• Length: 267
• Species: Homo sapiens
• Alignment Length: 243
• Identity: 54/243 - (22%)
• Similarity: 87/243 - (35%)
• Gaps: 53/243 - (21%)

  Fly     9 IYVGNLPPDIRTKDIQDLFHKFGKVTFVDL-KNRRGPP--FAFVEFEDARDADDAVKARDGYDYD 70
            ::||||...:..:.:.:|||:.|.|..|.: |::.|.|  ||||.|:.......|:...:|....
Human    12 LFVGNLETKVTEELLFELFHQAGPVIKVKIPKDKDGKPKQFAFVNFKHEVSVPYAMNLLNGIKLY 76

  Fly    71 GYRLRVEFPRGGGPGSYRGGNRNDRSRDGGGRMGGRGPPAKRSQYRVMVTGLPASGSWQDLKDHM 135
            |..::::|..|.....      .|.|........|...|          |....|..::...|:|
Human    77 GRPIKIQFRSGSSHAP------QDVSLSYPQHHVGNSSP----------TSTSPSSRYERTMDNM 125

  Fly   136 REAGDVCFADTYKDGSGVVEFLRHEDMKYAIKKLDDSRFRSHEGEVAYIRVREDSGDNDRGGGGG 200
            ..:..:    ..:..|....|.|...|..|::            :::|                |
Human   126 TSSAQI----IQRSFSSPENFQRQAVMNSALR------------QMSY----------------G 158

  Fly   201 GSGGGGGGSGGGGSRDYRDRSRSRSFSSRPR-RRGTP-TYSPVRRQSY 246
            |..|.......|.|...:..|.|.:.||..: |:||| :...||..||
Human   159 GKFGSSPLDQSGFSPSVQSHSHSFNQSSSSQWRQGTPSSQRKVRMNSY 206

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SF2	NP_652611.1	RRM_SF	3..80	CDD:473069	22/73 (30%)
		RRM2_SRSF1_like	115..188	CDD:410013	10/72 (14%)
RBM7	NP_001272974.1	RRM_RBM7	9..83	CDD:410005	21/70 (30%)
		ZCCHC8 binding. /evidence=ECO:0000269|PubMed:27905398, ECO:0007744|PDB:5LXR, ECO:0007744|PDB:5LXY	25..35		3/9 (33%)
		ZCCHC8 binding. /evidence=ECO:0000269|PubMed:27905398, ECO:0007744|PDB:5LXR, ECO:0007744|PDB:5LXY	59..76		2/16 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..267		14/44 (32%)