DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spt5 and KTF1

DIOPT Version :9

Sequence 1:	NP_652610.1	Gene:	Spt5 / 53442	FlyBaseID:	FBgn0040273	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_196049.1	Gene:	KTF1 / 830308	AraportID:	AT5G04290	Length:	1493	Species:	Arabidopsis thaliana

Alignment Length:	1014	Identity:	229/1014 - (22%)
Similarity:	365/1014 - (35%)	Gaps:	302/1014 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 DNRGKSDESGEEEEEPPGEDIDSEEYDEEENDDHPR-KKKKKERFGGFIIDEAEVDDEVDEDDEW 131
            |.:||..:....:....|:   ..:...|..|:..| ||:|......|..:.|||.......||.
plant     2 DRKGKGKQVAGSDSYSGGQ---KRKNSVEFRDEGLRIKKRKNPEVLQFFEESAEVGYYGGSSDED 63

  Fly   132 EEGANEIGIVGN-----EIDELGPTARDIEIRRRGTNLWDTQKEDEIEE-----YLRKKYADESI 186
            ::|   :|.:.:     |::|.....:.    .:|.:.:...||:::.|     .:.::|...|.
plant    64 DDG---LGFLNDMEDEPEVEESSKAGKG----EKGKSSFVFPKEEDLNEEEFDRIMEERYKPGSG 121

  Fly   187 AKRHFGDGGEEMSDEITQQTLLPGIKDPNLWMVKCRIGEEKATALLLMRKYLTYLNTDDPLQIKS 251
            ..|:..|   ::.|.|....|.|..|||.:|.|||.||.|:.:...||.|::........|:|.|
plant   122 FLRYADD---DIKDAIEMDALAPTSKDPPIWKVKCAIGRERRSVFCLMHKFVELRKIGTKLEIIS 183

  Fly   252 IIAPEGVKGYIYLEAYKQTHV-KTCIDNVGNLRMGKWKQEMVPIKEMTDVLKVVKEQVGLKVKQW 315
            :.:.:.|||:|::||.|:..| :.|...||   :...:..::|..|..::|.|.|:...:....|
plant   184 VFSVDHVKGFIFIEADKEHDVLEACKSLVG---IYATRMVLLPKAETPNLLTVQKKTKKVSEGTW 245

  Fly   316 VRLKRGLYKDDIAQVDYVDLAQNQVHLKLLPRID-----------YTRMRGALRTTATESDDSKR 369
            .|:|.|.||.|:||:..|...:|:..:||:||||           .|..:|  :|.|.....|..
plant   246 ARVKNGKYKGDLAQIVAVSDTRNKALIKLIPRIDIQALTQKYGGGVTVQKG--QTPAPRLISSSE 308

  Fly   370 KKKRRPAAKPFDPEAVRAIGGEVHSDGDF-LLFE--GNRYSRKGFLYKNFTMSAILSDGVKPTLA 431
            .::.||..             :|..|.|. :.||  .:...:.|:|||..::.:|.|.||.||..
plant   309 LEEFRPLI-------------QVRRDRDTGITFEHLDSLMLKDGYLYKKVSLDSISSWGVIPTKD 360

  Fly   432 ELERFEESPEEVNLEIMGTVKDDPTMAHSFSMGDNVEVCVGDLENLQAKIVAIDGTMITVMPKHQ 496
            ||.:|                 .|.        |..|  .||:|.:..
plant   361 ELLKF-----------------TPV--------DRKE--TGDVEWISE----------------- 381

  Fly   497 DLKDPLIFKASELRKYFKT----------------------GDHARVLAGRYEGETGLIIRVEPT 539
                  |:.....:|...|                      |:.:|  .|:.||.
plant   382 ------IYGEERKKKILPTCREGGKGEGSGGGKGEGSGGGKGEGSR--GGKGEGS---------- 428

  Fly   540 RVVLVSDL---TNHELEVLPRDLQLCSDVATGVDCLGQFQWGDMVQLDSQNVGVIVRLERENFHV 601
                 ||.   :::||..|.              |..:..:|.:|.:|.:..|..|..|
plant   429 -----SDFKSESSYELYNLV--------------CFSRKDFGLIVGVDDKGDGYKVLKE------ 468

  Fly   602 LGMNGKCIECKPTALHKRKEN----RHTVALDADQNQIRRRDVVKVMEGPHAGRSGEIKHLYRSL 662
             |::|..:   .|...|..:|    ....|||.::.||...||||:.:||..|:.|.::.:||.:
plant   469 -GIDGPVV---VTVGKKEMQNGPFDSKFTALDLNKKQISVNDVVKISKGPSEGKQGVVRQVYRGI 529

  Fly   663 AFLHCRMYTENGGIFVCKTRHLQLA------GGSKTTVSNAGIVGGLGF----MSPRIQSPMHP- 716
            .||:.....||||.|.||::..:..      ...||     |...|..|    .||:  ||:.|
plant   530 IFLYDESEEENGGYFCCKSQSCEKVKLFTEESNEKT-----GGFDGTAFEDFVSSPK--SPLSPE 587

  Fly   717 ----------SGGRGARGGARGGRGGFRVTRDREILGKTIKISGGPYKGAVGIVKDATESTARVE 771
                      |..:|..|....             :|:.::|..||.||.:..|.....|...|:
plant   588 KEWQPRERYNSSNQGDIGSTYS-------------IGQKLRIRVGPLKGYLCRVIALRYSDVTVK 639

  Fly   772 LHTSCQTISVDRNHIAIV----GVTGKEGSVSTYGRTPARTPGYGAQTPSYTAAGSKTPLVGSQT 832
            |.:..:..:|...|:|.|    .|....|...|....|....|..:.|..: |.|:.|   .|:.
plant   640 LDSQHKIFTVKSEHLAEVRDRNTVLSTSGDAGTGSFQPFGMLGTESSTGDW-AIGAGT---SSEG 700

  Fly   833 PNWD-----TDT----------------RTPYGTMTPSHDGSMT---PRHGAW-DPTANTTPARN 872
            .||:     ||:                :.|:|...|:.|.|.|   ....|| :..|...||..
plant   701 GNWNIGGPSTDSHESLNIERNMVQLCREKNPWGGSKPTSDVSPTVADDNTSAWANAAAENKPASA 765

  Fly   873 NDFDYSLEEPSPSPGYNP--STPGYQMTSQFAPQTPGTLYGSDRSYSPFNPSPSPAPSPYPVGYM 935
            :|      :|.   |:||  .||..:         .||:.|
plant   766 SD------QPG---GWNPWGKTPASE---------AGTVSG------------------------ 788

  Fly   936 NTPSPSTYSPNTPGGIPQSPYNPQTPGASLDSSMGDWCT 974
                   :...:...:..|.:..|....|..:.:|.|.|
plant   789 -------WGDTSASNVEASSWEKQGASTSNVADLGSWGT 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spt5	NP_652610.1	Spt5_N	<136..208	CDD:288770	13/81 (16%)
		nusG	212..352	CDD:181467	49/151 (32%)
		NGN_Euk	215..302	CDD:193577	26/87 (30%)
		KOW_Spt5_1	313..350	CDD:240505	17/47 (36%)
		KOW_Spt5_2	461..511	CDD:240506	6/49 (12%)
		KOW_Spt5_3	512..562	CDD:240507	11/74 (15%)
		KOW_Spt5_4	638..680	CDD:240508	17/41 (41%)
		KOW_Spt5_5	737..788	CDD:240509	12/50 (24%)
		CTD	812..908	CDD:215026	27/122 (22%)
		CTD	812..870	CDD:289577	18/82 (22%)
		KOW_Spt5_6	1020..1075	CDD:240510
KTF1	NP_196049.1	NGN_Euk	147..232	CDD:193577	26/87 (30%)
		KOW_Spt5_1	243..280	CDD:240505	16/36 (44%)
		SPT5	<435..907	CDD:227493	107/483 (22%)
		KOW_Spt5_4	506..547	CDD:240508	17/40 (43%)
		KOW	610..656	CDD:294253	12/45 (27%)
		MSP1a	795..>886	CDD:288513	6/26 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	73	1.000	Domainoid score	I3272
eggNOG	1	0.900	-	-		E1_COG5164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D828863at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11125
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.970