DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spt5 and GTA2

DIOPT Version :9

Sequence 1:	NP_652610.1	Gene:	Spt5 / 53442	FlyBaseID:	FBgn0040273	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_192575.3	Gene:	GTA2 / 826391	AraportID:	AT4G08350	Length:	1041	Species:	Arabidopsis thaliana

Alignment Length:	1109	Identity:	359/1109 - (32%)
Similarity:	537/1109 - (48%)	Gaps:	137/1109 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RSKSRSRSRSGSRGSRSVSRSRSRSQSGHSRSGSESPQRRDNRGKS---DESGEEEEEPPGEDID 89
            ||:.......|...:..:.......:......|......|..||:|   |:..||:.:.  ||.|
plant     3 RSRDEDDELDGDYEALDLEEEEEEDEEEEEERGRGGGGSRRKRGRSNFIDDYAEEDSQE--EDDD 65

  Fly    90 SEEYDEEENDDHPRKKKKKERFGGFIIDEA-EVDDEVDEDDEWEEGANEIGIVGNEIDELGPTAR 153
            .|:|...........|:||.....|:..|| :||   |||:|.|:.|.:..||.|..| |.....
plant    66 DEDYGSSRGGKGAASKRKKPSASIFLDREAHQVD---DEDEEEEDEAEDDFIVDNGTD-LPDERG 126

  Fly   154 DIEIRRRGTNLWDTQKEDEIEEYLRKKYADESIAKRHFGDGGEEMSDEITQQTLLPGIKDPNLWM 218
            |....||  .|...:.::::|:..|:  ..|..:.||..:..|| :.|:.||.|||.::||.|||
plant   127 DRRYERR--FLPRDENDEDVEDLERR--IQERFSSRHHEEYDEE-ATEVEQQALLPSVRDPKLWM 186

  Fly   219 VKCRIGEEKATALLLMRKYLTYLNTDDPLQIKSIIAPEGVKGYIYLEAYKQTHVKTCIDNVGNLR 283
            |||.||.|:..|:.||:|   :::....|||:|::|.:.:|.:||:||.|:.|||..|..:.|:.
plant   187 VKCAIGREREVAVCLMQK---FIDRGADLQIRSVVALDHLKNFIYVEADKEAHVKEAIKGMRNIY 248

  Fly   284 MGKWKQEMVPIKEMTDVLKVVKEQVGLKVKQWVRLKRGLYKDDIAQVDYVDLAQNQVHLKLLPRI 348
            ..: |..:|||:||||||.|..:.:.|....|||:|.|.||.|:|:|..||..:.:|.:||:|||
plant   249 ANQ-KILLVPIREMTDVLSVESKAIDLSRDTWVRMKIGTYKGDLAKVVDVDNVRQRVTVKLIPRI 312

  Fly   349 DYTRMRGALRTTATESDDSKRKKKRR--PAAKPFDPEAVRAIGGEV-----HSDGDFLLFEGNRY 406
            |       |:..|::.|..:..||:.  |..:..:.:..|.:...|     |..||:....|...
plant   313 D-------LQALASKLDGREVSKKKAFVPPPRFMNIDEARELHIRVERRRDHMTGDYFENIGGML 370

  Fly   407 SRKGFLYKNFTMSAILSDGVKPTLAELERFEESPE--EVNLEIMGTVKDDPTMAHSFSMGDNVEV 469
            .:.||.||..::.:|....|.||..|||:|.:..|  |.:...:.|:..:....| |..||.|.|
plant   371 FKDGFHYKQVSLKSITVQNVTPTFDELEKFNKPSENGEGDFGGLSTLFANRKKGH-FMKGDAVIV 434

  Fly   470 CVGDLENLQAKIVAIDGTMITVMPKHQDLKDPLIFKASELRKYFKTGDHARVLAGRYEGETGLII 534
            ..|||:||:..:..:|...:.:..:.:.|.|||.....||.|||:.|:|.:|::|.:||.||:::
plant   435 IKGDLKNLKGWVEKVDEENVLIRSEVKGLPDPLAVNERELCKYFEPGNHVKVVSGTHEGATGMVV 499

  Fly   535 RVEPTRVVLVSDLTNHELEVLPRDLQLCSDVATGVDCLGQFQWGDMVQLDSQNVGVIVRLERENF 599
            :|:...::::||.|...:.|....:...|:|.|||..:|.::..|:|.||:.:.|||:|||.|.|
plant   500 KVDQHVLIILSDTTKEHVRVFADHVVESSEVTTGVTKIGDYELHDLVLLDNLSFGVIIRLENEAF 564

  Fly   600 HVLGMNGKCIECKP-TALHKRKE-----NRHTVALDADQNQIRRRDVVKVMEGPHAGRSGEIKHL 658
            .||    |.:..:| .||.|.:|     .:.....|..:|.|..:|.|:|:|||..|:.|.:||:
plant   565 QVL----KGVPDRPEVALVKLREIKCKLEKKINVQDRYKNVIAVKDDVRVIEGPSKGKQGPVKHI 625

  Fly   659 YRSLAFLHCRMYTENGGIFVCKTRHLQLAGGSKTTVSNAG-----IVGGLGFMSPRIQSPMHPSG 718
            |:.:.|::.|.:.|:.|....|.....:.|||::..:..|     ..|.....:|...||.....
plant   626 YKGVLFIYDRHHLEHAGFICAKCTSCIVVGGSRSGANRNGGDSLSRYGNFKAPAPVPSSPGRFQR 690

  Fly   719 GRGARGGARGGR-GGFRVTRDREILGKTIKISGGPYKGAVGIVKDATESTARVELHTSCQTISVD 782
            |||......||| ||.|...|..:||.|:||..||:||..|.|.:...::.||||  ..:.::||
plant   691 GRGGGYNNSGGRHGGGRGRGDDSLLGTTVKIRLGPFKGYRGPVVEVKGNSVRVEL--EMKIVTVD 753

  Fly   783 RNHIAIVGVTGKEGSVSTYGRTPAR-TPGY--GAQTPSYTAAGSKTPLVGSQTPNWDTDTRTPYG 844
            |..|:        .:|:|   ||.| |..|  |::||.:.   |:|||....||..|:..
plant   754 RGAIS--------DNVAT---TPFRDTSRYSMGSETPMHP---SRTPLHPYMTPMRDSGA----- 799

  Fly   845 TMTPSHDGSMTP-RHGAWDPTANTTPARNNDFD-------------------YSLEEPSPSPGYN 889
              ||.|||..|| |..||:|....:|.|:|..|                   .:.|.|:|..|:
plant   800 --TPIHDGMRTPMRDRAWNPYTPMSPPRDNWEDGNPGSWGTSPQYQPGSPPSRAYEAPTPGSGW- 861

  Fly   890 PSTPGYQMTSQFAPQTPGTLYGSDRSYSPFNPSPSPAPSPY---PVGYMNTPSPSTYSPNTPGGI 951
            .||||...:....|:..|:.|.:             |||||   ..|...|||.::|.|.||||
plant   862 ASTPGGSYSDAGTPRDHGSAYAN-------------APSPYLPSTPGQPMTPSSASYLPGTPGG- 912

  Fly   952 PQSPYNPQTPGASLDSSM----GD---WCTTDIEVRIH-THDDTDLVGQTGIIRTVSNGVCSVFL 1008
                 .|.|||..||...    ||   |...||.|.|| ..:|||:    |:||.||:|.|.|.|
plant   913 -----QPMTPGTGLDVMSPVIGGDAEAWFMPDILVDIHKAGEDTDV----GVIRDVSDGTCKVSL 968

  Fly  1009 RQ--EDRSVSIVSEHLAPVLPCNGDEFKIIYGDDRESVGRVLSKDGDVFVCRI--NEEIKLLPIN 1069
            ..  |..::..:...|..:.|...|..||:.|..|.|.|:::..||...:.:|  |.::|:|.:.
plant   969 GSSGEGDTIMALPSELEIIPPRKSDRVKIVGGQYRGSTGKLIGIDGSDGIVKIDDNLDVKILDLA 1033

  Fly  1070 FLCK 1073
            .|.|
plant  1034 LLAK 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spt5	NP_652610.1	Spt5_N	<136..208	CDD:288770	19/71 (27%)
		nusG	212..352	CDD:181467	62/139 (45%)
		NGN_Euk	215..302	CDD:193577	38/86 (44%)
		KOW_Spt5_1	313..350	CDD:240505	18/36 (50%)
		KOW_Spt5_2	461..511	CDD:240506	17/49 (35%)
		KOW_Spt5_3	512..562	CDD:240507	15/49 (31%)
		KOW_Spt5_4	638..680	CDD:240508	15/41 (37%)
		KOW_Spt5_5	737..788	CDD:240509	20/50 (40%)
		CTD	812..908	CDD:215026	34/115 (30%)
		CTD	812..870	CDD:289577	21/58 (36%)
		KOW_Spt5_6	1020..1075	CDD:240510	17/56 (30%)
GTA2	NP_192575.3	Spt5_N	105..177	CDD:403226	22/77 (29%)
		NGN_Euk	183..266	CDD:193577	38/86 (44%)
		KOW_Spt5_1	277..314	CDD:240505	19/43 (44%)
		SPT5	334..888	CDD:227493	183/595 (31%)
		KOW_Spt5_6	982..1039	CDD:240510	17/56 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	210	1.000	Domainoid score	I794
eggNOG	1	0.900	-	-		E1_COG5164
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2384
Inparanoid	1	1.050	447	1.000	Inparanoid score	I396
OMA	1	1.010	-	-		QHG54675
OrthoDB	1	1.010	-	-		D828863at2759
OrthoFinder	1	1.000	-	-		FOG0003457
OrthoInspector	1	1.000	-	-		otm3409
orthoMCL	1	0.900	-	-		OOG6_101219
Panther	1	1.100	-	-	O	PTHR11125
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2825
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840