Protein Alignment Spt5 and Spt5

DIOPT Version :10

• Sequence 1: NP_652610.1
• Gene: Spt5 / 53442
• FlyBaseID: FBgn0040273
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: XP_001231045.2
• Gene: Spt5 / 4576284
• VectorBaseID: AGAMI1_002313
• Length: 1090
• Species: Anopheles gambiae
• Alignment Length: 1096
• Identity: 790/1096 - (72%)
• Similarity: 912/1096 - (83%)
• Gaps: 40/1096 - (3%)

  Fly     9 MSDSGSEDGSISNKSQRSARSKSRSRSRSGSRGSRSVSRSRSRSQS-GHSRSGSESP---QRRDN 69
            ||||||...:.|..|.||.:|...:||     .|||||||..||:| ..|:|.:|.|   ||:|.
Mosquito     1 MSDSGSGSDADSVASNRSRKSGGSNRS-----VSRSVSRSPQRSRSPSTSQSDNERPRKKQRKDR 60

  Fly    70 RGKSD------ESGEEEEEPPGEDIDSEEYDEEENDDHPR----KKKKKERFGGFIIDEAEVDDE 124
            |...|      |..|:|:||.|||:|||||||||.||..|    ||||:||||||||||||||||
Mosquito    61 RRLDDEDDDDEEEAEDEQEPEGEDLDSEEYDEEEEDDDRRGGRKKKKKQERFGGFIIDEAEVDDE 125

  Fly   125 VDEDDEWEEGANEIGIVGNEIDELGPTARDIEIRRRGTNLWDTQKEDEIEEYLRKKYADESIAKR 189
            ||||||||:||.|:|||.|||:|:|.|||:||.|||||||||:.||||:.|||::||||.|:|:|
Mosquito   126 VDEDDEWEDGAQEMGIVSNEIEEVGQTAREIENRRRGTNLWDSHKEDELAEYLKRKYADASVARR 190

  Fly   190 HFGDGGEEMSDEITQQTLLPGIKDPNLWMVKCRIGEEKATALLLMRKYLTYLNTDDPLQIKSIIA 254
            .||||||||||||||||||||||||||||||||||||||||||||||:|||.|||.|:||||::|
Mosquito   191 QFGDGGEEMSDEITQQTLLPGIKDPNLWMVKCRIGEEKATALLLMRKFLTYQNTDQPMQIKSVVA 255

  Fly   255 PEGVKGYIYLEAYKQTHVKTCIDNVGNLRMGKWKQEMVPIKEMTDVLKVVKEQVGLKVKQWVRLK 319
            ||.||||||:|||||.|||:.|:||||||:|.|||||||||:|||:|||||||.|||.|||||||
Mosquito   256 PESVKGYIYIEAYKQAHVKSAINNVGNLRVGIWKQEMVPIKDMTDILKVVKEQTGLKPKQWVRLK 320

  Fly   320 RGLYKDDIAQVDYVDLAQNQVHLKLLPRIDYTRMRGALRTTATESDDSKRKKKRRPAAKPFDPEA 384
            ||:||||||||||||||||||||||||||||||:|||||.|.||.....::||||||||.|||||
Mosquito   321 RGIYKDDIAQVDYVDLAQNQVHLKLLPRIDYTRLRGALRATQTEESSDAKRKKRRPAAKSFDPEA 385

  Fly   385 VRAIGGEVHSDGDFLLFEGNRYSRKGFLYKNFTMSAILSDGVKPTLAELERFEESPEEVNLEIMG 449
            :||||||:.||||||:||||||||||||||.|||||:|:|||||||||||||||.|||:|:|:..
Mosquito   386 IRAIGGELTSDGDFLIFEGNRYSRKGFLYKAFTMSAVLADGVKPTLAELERFEEQPEEINIELAV 450

  Fly   450 TVKDDPTMAHSFSMGDNVEVCVGDLENLQAKIVAIDGTMITVMPKHQDLKDPLIFKASELRKYFK 514
            :.|:||..|||||||||||||||||.||||||:||||::|||||||::|:|||||||:|||||||
Mosquito   451 SSKEDPVTAHSFSMGDNVEVCVGDLMNLQAKIIAIDGSLITVMPKHEELRDPLIFKAAELRKYFK 515

  Fly   515 TGDHARVLAGRYEGETGLIIRVEPTRVVLVSDLTNHELEVLPRDLQLCSDVATGVDCLGQFQWGD 579
            ||||.:|||||||||||||:||||:|:|||||||.|||||||||||||:|:|||||.||.:||||
Mosquito   516 TGDHVKVLAGRYEGETGLIVRVEPSRIVLVSDLTMHELEVLPRDLQLCTDMATGVDSLGIYQWGD 580

  Fly   580 MVQLDSQNVGVIVRLERENFHVLGMNGKCIECKPTALHKRKENRHTVALDADQNQIRRRDVVKVM 644
            :||||:|.|||||||||||||||||:||.||||||||.||:|||:|:|||.|||||||:|:||||
Mosquito   581 LVQLDAQTVGVIVRLERENFHVLGMHGKVIECKPTALQKRRENRNTIALDWDQNQIRRKDIVKVM 645

  Fly   645 EGPHAGRSGEIKHLYRSLAFLHCRMYTENGGIFVCKTRHLQLAGGSKTTVSNAGIV----GGLGF 705
            ||||.||.||||||||:|||||.|||||||||||.||||||||||:|..:.|:..:    || |.
Mosquito   646 EGPHTGRDGEIKHLYRNLAFLHSRMYTENGGIFVVKTRHLQLAGGNKNPMQNSNPMMSPFGG-GI 709

  Fly   706 MSPRIQSPMHPSGGRG------ARGGARGGRGGFRVTRDREILGKTIKISGGPYKGAVGIVKDAT 764
            |||||.||||||||||      .|||..|||||.||:|||||||:||:|:|||||||||||||||
Mosquito   710 MSPRIHSPMHPSGGRGGGGGGPTRGGRGGGRGGARVSRDREILGRTIRITGGPYKGAVGIVKDAT 774

  Fly   765 ESTARVELHTSCQTISVDRNHIAIV-GVTGKEGSVSTYGRTPARTP--GYGAQTPSYTAAGSKTP 826
            |:|||||||:||||||||||||||| |...|.||||:|.|||:|||  .||||||.|  :|||||
Mosquito   775 ETTARVELHSSCQTISVDRNHIAIVDGGATKAGSVSSYMRTPSRTPAGSYGAQTPVY--SGSKTP 837

  Fly   827 LVGSQTPNWDTDTRTPYGTMTPSHDGSMTPRHGAWDPTANTTPARNNDFDYSLEEPSPSPGYNPS 891
            |.|||||.:|..:|||||:|||||||||||||||||||.:.||||:||||: :||||||||||||
Mosquito   838 LHGSQTPQYDPGSRTPYGSMTPSHDGSMTPRHGAWDPTVSNTPARSNDFDF-MEEPSPSPGYNPS 901

  Fly   892 TPGYQMTSQFAPQTPGTLYGSDRSYSPFNPSPSPAPSPYPV-GYMNTPSPSTYSPNTPGGIPQSP 955
            |||||:.:.:||.|||.::.:| :|||:..||:|:||||.| ||:.|||||.|||.|||. |.||
Mosquito   902 TPGYQINTPYAPHTPGNMFNAD-NYSPYQASPNPSPSPYQVGGYIGTPSPSAYSPATPGA-PASP 964

  Fly   956 YNPQTPGASLDSSMGDWCTTDIEVRIHTHDDTDLVGQTGIIRTVSNGVCSVFLRQEDRSVSIVSE 1020
            ||||||||.||..:|||.||||||.|.:|.|:||.|||||||||:||.|.|||.:||..|::...
Mosquito   965 YNPQTPGAGLDPQLGDWFTTDIEVTIRSHGDSDLSGQTGIIRTVNNGDCVVFLPEEDHCVTVPLS 1029

  Fly  1021 HLAPVLPCNGDEFKIIYGDDRESVGRVLSKDG-DVFVCRINEEIKLLPINFLCKMK 1075
            :|.||||..|::||:|.|:|||:||..:...| :..|..||.:..|:|:|::.:.:
Mosquito  1030 NLQPVLPEPGEKFKVIVGEDRETVGEFIDMSGSNEAVVMINGQSTLIPMNYMARYR 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spt5	NP_652610.1	Spt5_N	<139..209	CDD:463406	53/69 (77%)
		NGN_Euk	215..302	CDD:193577	70/86 (81%)
		KOW_Spt5_1	313..350	CDD:240505	35/36 (97%)
		KOW_Spt5_2	461..511	CDD:240506	41/49 (84%)
		KOW_Spt5_3	512..562	CDD:240507	43/49 (88%)
		KOW_Spt5_4	638..680	CDD:240508	35/41 (85%)
		KOW_Spt5_5	737..788	CDD:240509	45/50 (90%)
		CTD	812..908	CDD:215026	71/95 (75%)
		KOW_Spt5_6	1020..1075	CDD:240510	22/55 (40%)
Spt5	XP_001231045.2	Spt5_N	<135..210	CDD:463406	59/74 (80%)
		NGN_Euk	216..303	CDD:193577	69/86 (80%)
		KOW_Spt5_1	314..351	CDD:240505	34/36 (94%)
		KOW_Spt5_2	462..512	CDD:240506	41/49 (84%)
		KOW_Spt5_3	513..563	CDD:240507	43/49 (88%)
		KOW_Spt5_4	639..681	CDD:240508	36/41 (88%)
		KOW_Spt5_5	747..798	CDD:240509	42/51 (82%)
		CTD	825..926	CDD:215026	68/101 (67%)
		KOW_Spt5_6	1029..1085	CDD:240510	13/40 (33%)