DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spt5 and Supt5h

DIOPT Version :9

Sequence 1:	NP_652610.1	Gene:	Spt5 / 53442	FlyBaseID:	FBgn0040273	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001100967.2	Gene:	Supt5h / 308472	RGDID:	1563807	Length:	1083	Species:	Rattus norvegicus

Alignment Length:	1138	Identity:	594/1138 - (52%)
Similarity:	774/1138 - (68%)	Gaps:	122/1138 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDSEVSNMSDSGSEDGSISNKSQRSARSKSRSRSRSGSRGSRSVSRSRSRSQSGHSRSGSESPQ 65
            |||||.||.|:  .||...|::::.:...:.|                       .|.:|||
  Rat     1 MSDSEDSNFSE--EEDSERSSEAEEAEVEEDR-----------------------RSAAGSE--- 37

  Fly    66 RRDNRGKSDESGEEEEEPPGEDIDSEEYDEEENDDHPRKKKKKERFGGFIIDEAEVDDEVDEDDE 130
                  |.:|..|||||      :.|||||||.::...:..||.|.||||:|||:||||.:::|:
  Rat    38 ------KEEEPEEEEEE------EEEEYDEEEEEEDDDRPPKKPRHGGFILDEADVDDEYEDEDQ 90

  Fly   131 WEEGANEI----GIVGNEIDELGPTARDIEIRRRGTNLWDTQKEDEIEEYLRKKYADESIAKRHF 191
            ||:||.:|    .|..:.||.: ....|....||..|||..|:|:|:.||..||||..|:.:..:
  Rat    91 WEDGAEDILEKEEIEASNIDNV-VLDEDRSGARRLQNLWRDQREEELGEYYMKKYAKSSVGETVY 154

  Fly   192 GDGGEEMSDEITQQTLLPGIKDPNLWMVKCRIGEEKATALLLMRKYLTYLNTDDPLQIKSIIAPE 256
            | |.:|:||:||||.||||:||||||.|||:||||:|||:.||||::.|..||.||||||::|||
  Rat   155 G-GSDELSDDITQQQLLPGVKDPNLWTVKCKIGEERATAISLMRKFIAYQFTDTPLQIKSVVAPE 218

  Fly   257 GVKGYIYLEAYKQTHVKTCIDNVGNLRMGKWKQEMVPIKEMTDVLKVVKEQVGLKVKQWVRLKRG 321
            .||||||:|||||||||..|:.|||||:|.|.|:||||||||||||||||...||.|.|||||||
  Rat   219 HVKGYIYVEAYKQTHVKQAIEGVGNLRLGYWNQQMVPIKEMTDVLKVVKEVANLKPKSWVRLKRG 283

  Fly   322 LYKDDIAQVDYVDLAQNQVHLKLLPRIDYTRMRGALRTTATESDDSKRKKKRRPAAKPFDPEAVR 386
            :|||||||||||:.:||.:.||::|||||.|::..:   :.:...:||||.:||..:.||.|.:|
  Rat   284 IYKDDIAQVDYVEPSQNTISLKMIPRIDYDRIKARM---SLKDWFAKRKKFKRPPQRLFDAEKIR 345

  Fly   387 AIGGEVHSDGDFLLFEGNRYSRKGFLYKNFTMSAILSDGVKPTLAELERFEESPEEVNLEIMGTV 451
            ::||:|.||||||:||||||||||||:|:|.|||::::||||||:|||:||:.||.::||:: |.
  Rat   346 SLGGDVASDGDFLIFEGNRYSRKGFLFKSFAMSAVITEGVKPTLSELEKFEDQPEGIDLEVV-TE 409

  Fly   452 KDDPTMAHSFSMGDNVEVCVGDLENLQAKIVAIDGTMITVMPKHQDLKDPLIFKASELRKYFKTG 516
            .......|:|..|||||||.|:|.|||.|::::||..||:||||:||||.|.|.|.|||||||.|
  Rat   410 STGKEREHNFQPGDNVEVCEGELINLQGKVLSVDGNKITIMPKHEDLKDMLEFPAQELRKYFKMG 474

  Fly   517 DHARVLAGRYEGETGLIIRVEPTRVVLVSDLTNHELEVLPRDLQLCSDVATGVDCLGQFQWGDMV 581
            ||.:|:|||:||:||||:|||...|:|.||||.|||:||||||||||:.|:|||..||.:||::|
  Rat   475 DHVKVIAGRFEGDTGLIVRVEENFVILFSDLTMHELKVLPRDLQLCSETASGVDVGGQHEWGELV 539

  Fly   582 QLDSQNVGVIVRLERENFHVLGMNGKCIECKPTALHKRKENRHTVALDADQNQIRRRDVVKVMEG 646
            |||.:.||||||||||.|.||.|:||.:..:..|:.::|:||..||||:|||.|..:|:|||::|
  Rat   540 QLDPRTVGVIVRLERETFQVLNMHGKVVTVRHQAVTQKKDNRFAVALDSDQNNIHVKDIVKVIDG 604

  Fly   647 PHAGRSGEIKHLYRSLAFLHCRMYTENGGIFVCKTRHLQLAGGSK-TTVSNAGIVGGLGFMSPRI 710
            ||:||.|||:|||||.|||||:...||||:||||.|||.|||||| ..|:|. .|||...|||||
  Rat   605 PHSGREGEIRHLYRSFAFLHCKKLVENGGMFVCKARHLVLAGGSKPRDVTNL-TVGGFTPMSPRI 668

  Fly   711 QSPMHPS-----GGRGARGGARGGRGGFRVTRDREILGKTIKISGGPYKGAVGIVKDATESTARV 770
            .||||||     ||.|:.||...|||    .||.|::|:|::||.|||||.:|:|||||||||||
  Rat   669 SSPMHPSAEGQHGGFGSPGGMSRGRG----RRDNELIGQTVRISQGPYKGYIGVVKDATESTARV 729

  Fly   771 ELHTSCQTISVDRNHIAIVGVTGKEGSVSTYGRTPARTPGYGAQTPSYTAAGSKTPLVGSQTPNW 835
            |||::||||||||..:..|......|..|||||||.    ||:|||.| .:||:||:.|||||..
  Rat   730 ELHSTCQTISVDRQRLTTVDSQRPGGMTSTYGRTPM----YGSQTPMY-GSGSRTPMYGSQTPLQ 789

  Fly   836 DTDTRTP-YGTMTPSHDGSMTP-RHGAWDPTANTTPAR-NNDFDYSL-EEPSPSP-GY----NPS 891
            | .:||| ||:.||.||||.|| :.|||||....||:| ..:::|:. :||:||| .|    ||.
  Rat   790 D-GSRTPHYGSQTPLHDGSRTPAQSGAWDPNNPNTPSRAEEEYEYAFDDEPTPSPQAYGGTPNPQ 853

  Fly   892 TPGY------QMTSQFAPQTPGT--LYGSDRSYSP---------FNPSPSPAP----SPYPVGYM 935
            ||||      |:..|:.||||||  :|.:|: :||         :.|||||..    :|.|.||.
  Rat   854 TPGYPDPSSPQVNPQYNPQTPGTPAMYNTDQ-FSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQ 917

  Fly   936 NT--------------------PSPSTYSPNTPGGIPQSPYNPQTPGASLDSSMGDWCTTDIEVR 980
            ||                    |||..|||.|||......|||.|||:.::.:..||.||||:|:
  Rat   918 NTHSPASYHPTPSPMAYQASPSPSPVGYSPMTPGAPSPGGYNPHTPGSGIEQNSSDWVTTDIQVK 982

  Fly   981 IH-THDDTDLVGQTGIIRTVSNGVCSVFLRQEDRSVSIVSEHLAPVLPCNGDEFKIIYGDDRESV 1044
            :. |:.||.:|||||:||:|:.|:|||:|:..::.|||.||||.|:.|...::.|:|.|:|||:.
  Rat   983 VRDTYLDTQIVGQTGVIRSVTGGMCSVYLKDSEKVVSISSEHLEPITPTKNNKVKVILGEDREAT 1047

  Fly  1045 GRVLSKDGDVFVCRI---NEEIKLLPINFLCKM 1074
            |.:||.||:..:.|:   :::||:|.:.||.|:
  Rat  1048 GVLLSIDGEDGIIRMDLEDQQIKILNLRFLGKL 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spt5	NP_652610.1	Spt5_N	<136..208	CDD:288770	29/75 (39%)
		nusG	212..352	CDD:181467	102/139 (73%)
		NGN_Euk	215..302	CDD:193577	63/86 (73%)
		KOW_Spt5_1	313..350	CDD:240505	26/36 (72%)
		KOW_Spt5_2	461..511	CDD:240506	31/49 (63%)
		KOW_Spt5_3	512..562	CDD:240507	35/49 (71%)
		KOW_Spt5_4	638..680	CDD:240508	28/41 (68%)
		KOW_Spt5_5	737..788	CDD:240509	35/50 (70%)
		CTD	812..908	CDD:215026	55/110 (50%)
		CTD	812..870	CDD:289577	34/59 (58%)
		KOW_Spt5_6	1020..1075	CDD:240510	23/58 (40%)
Supt5h	NP_001100967.2	Spt5_N	<92..171	CDD:403226	33/80 (41%)
		NGN_Euk	177..264	CDD:193577	63/86 (73%)
		KOW_Spt5_1	275..312	CDD:240505	26/36 (72%)
		SPT5	333..960	CDD:227493	350/639 (55%)
		KOW_Spt5_6	1023..1080	CDD:240510	22/56 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341983
Domainoid	1	1.000	482	1.000	Domainoid score	I392
eggNOG	1	0.900	-	-		E1_COG5164
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2384
Inparanoid	1	1.050	1035	1.000	Inparanoid score	I254
OMA	1	1.010	-	-		QHG54675
OrthoDB	1	1.010	-	-		D166902at33208
OrthoFinder	1	1.000	-	-		FOG0003457
OrthoInspector	1	1.000	-	-		oto95650
orthoMCL	1	0.900	-	-		OOG6_101219
Panther	1	1.100	-	-	LDO	PTHR11125
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2825
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770