DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spt5 and supt5h

DIOPT Version :9

Sequence 1:	NP_652610.1	Gene:	Spt5 / 53442	FlyBaseID:	FBgn0040273	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_012823543.1	Gene:	supt5h / 100170547	XenbaseID:	XB-GENE-1013282	Length:	1083	Species:	Xenopus tropicalis

Alignment Length:	1139	Identity:	586/1139 - (51%)
Similarity:	767/1139 - (67%)	Gaps:	119/1139 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDSEVSNMSDSGSEDGSISNKSQRSARSKSRSRSRSGSRGSRSVSRSRSRSQSGHSRSGSESPQ 65
            |||||.||.|:..|:..|.:.:.:.:...:....|.:||
Frog     1 MSDSEDSNFSEEESDRSSEAEEVEENEEVEEERASAAGS-------------------------- 39

  Fly    66 RRDNRGKSDESGEEEEEPPGEDIDSEEYDEEENDDHPRKKKKKERFGGFIIDEAEVDDEVDEDDE 130
                     |.|||||       |.|||||||.::...:.:||.|.||||:|||:||||.:::|:
Frog    40 ---------EKGEEEE-------DEEEYDEEEEEEDDDRPRKKPRHGGFILDEADVDDEYEDEDQ 88

  Fly   131 WEEGANEI-----GIVGNEIDELGPTARDIEIRRRGTNLWDTQKEDEIEEYLRKKYADESIAKRH 190
            ||:||.:|     .:..:.||.: ....|....||..|||..|:|:|:.||..||||..|:.:..
Frog    89 WEDGAEDILEKAEELEASNIDNV-VLDEDRSGARRLQNLWRDQREEELGEYYMKKYAKSSVGEHI 152

  Fly   191 FGDGGEEMSDEITQQTLLPGIKDPNLWMVKCRIGEEKATALLLMRKYLTYLNTDDPLQIKSIIAP 255
            :| |.:|:||:||||.||||:||||||.|||:||||:|||:.||||::.|..||.||||||::||
Frog   153 YG-GSDELSDDITQQQLLPGVKDPNLWTVKCKIGEERATAIALMRKFIAYQFTDTPLQIKSVVAP 216

  Fly   256 EGVKGYIYLEAYKQTHVKTCIDNVGNLRMGKWKQEMVPIKEMTDVLKVVKEQVGLKVKQWVRLKR 320
            |.||||||:|||||||||..|:.:||||||.|.|:||||||||||||||||...||.|.||||||
Frog   217 EHVKGYIYVEAYKQTHVKQAIEGIGNLRMGFWNQQMVPIKEMTDVLKVVKEVTNLKPKSWVRLKR 281

  Fly   321 GLYKDDIAQVDYVDLAQNQVHLKLLPRIDYTRMRGALRTTATESDDSKRKKKRRPAAKPFDPEAV 385
            |:|||||||||||:.:||.:.||::|||||.|::..:   :.:...:||||.|||..|.|:.|.:
Frog   282 GIYKDDIAQVDYVEPSQNTISLKMIPRIDYDRIKARM---SLKDWFAKRKKFRRPPQKHFNAEKI 343

  Fly   386 RAIGGEVHSDGDFLLFEGNRYSRKGFLYKNFTMSAILSDGVKPTLAELERFEESPEEVNLEIMGT 450
            |::||:|.||||||:||||||||||||:|:|.|||::::||||||:|||:||:.||.|:||:: |
Frog   344 RSLGGDVSSDGDFLIFEGNRYSRKGFLFKSFAMSAVITEGVKPTLSELEKFEDQPEGVDLEVV-T 407

  Fly   451 VKDDPTMAHSFSMGDNVEVCVGDLENLQAKIVAIDGTMITVMPKHQDLKDPLIFKASELRKYFKT 515
            ........||...|||||||.|:|.|||.||:::||..||:||||:||||.|.|.|.||||||:.
Frog   408 EATGKEREHSLQPGDNVEVCEGELINLQGKILSVDGNKITIMPKHEDLKDMLEFPAQELRKYFRM 472

  Fly   516 GDHARVLAGRYEGETGLIIRVEPTRVVLVSDLTNHELEVLPRDLQLCSDVATGVDCLGQFQWGDM 580
            |||.:|:||||||:||||:|||...|:|.||||.|||:||||||||||:.|:|||..||.:||::
Frog   473 GDHVKVIAGRYEGDTGLIVRVEENFVILFSDLTMHELKVLPRDLQLCSETASGVDVGGQHEWGEL 537

  Fly   581 VQLDSQNVGVIVRLERENFHVLGMNGKCIECKPTALHKRKENRHTVALDADQNQIRRRDVVKVME 645
            ||||.|.:|||||||||.|.||.|:||.:..:..|::::|:||..||||::.|.|..:|:|||::
Frog   538 VQLDPQTMGVIVRLERETFQVLNMHGKVVTVRHQAVNRKKDNRFAVALDSEDNNIHVKDIVKVID 602

  Fly   646 GPHAGRSGEIKHLYRSLAFLHCRMYTENGGIFVCKTRHLQLAGGSKTTVSNAGIVGGLGFMSPRI 710
            |||:||.|||:||:|:.|||||:...||||:||||||:|.||||||........:||...|||||
Frog   603 GPHSGREGEIRHLFRNYAFLHCKKLVENGGMFVCKTRYLVLAGGSKPRDVTNFTIGGFAPMSPRI 667

  Fly   711 QSPMHPSGGRGARGGARGGRGG-----FRVTRDREILGKTIKISGGPYKGAVGIVKDATESTARV 770
            .|||||||. |.|||..||.||     .|..||.:::|:|::||.|||||.:|:|||||||||||
Frog   668 SSPMHPSGS-GPRGGMAGGGGGGGAGRGRGRRDNDLIGQTVRISQGPYKGYIGVVKDATESTARV 731

  Fly   771 ELHTSCQTISVDRNHIAIVGVTGKEGSVSTYGRTPARTPGYGAQTPSYTAAGSKTPLVGSQTPNW 835
            |||::||||||||..:..||.....|:.||:    .|||.||:|||.| ..||:||:.|||||..
Frog   732 ELHSTCQTISVDRQRLTTVGARRSGGTTSTH----VRTPIYGSQTPMY-GTGSRTPMYGSQTPLH 791

  Fly   836 DTDTRTP-YGTMTPSHDGSMTP-RHGAWDPTANTTPAR-NNDFDYSL-EEPSPSP-GY----NPS 891
            | .:||| ||:.||.||||.|| :.|||||....||:| :.::||.. :|||||| ||    ||.
Frog   792 D-GSRTPHYGSQTPLHDGSRTPAQSGAWDPNNPNTPSRADEEYDYRYDDEPSPSPQGYGGTPNPQ 855

  Fly   892 TPGY------QMTSQFAPQTPGT--LYGSDRSYSP---------FNPSPSPAP----SPYPVGYM 935
            ||||      |:.:.:.||||||  :|.:|: :||         :.|||||..    :|.||||.
Frog   856 TPGYPDVPSPQVNAPYHPQTPGTPAMYNTDQ-FSPYAAPSPQGSYQPSPSPQSYHQVAPSPVGYQ 919

  Fly   936 NT--------------------PSPSTYSPNTPGGIPQSPYNPQTPGASLDSSMGDWCTTDIEVR 980
            ||                    |||..|||.|||......|||.|||:|::....||.||||:|:
Frog   920 NTHSPASYHPTPSPMAYQASPSPSPMGYSPMTPGAPSPGGYNPHTPGSSIEQISSDWVTTDIQVK 984

  Fly   981 IH-THDDTDLVGQTGIIRTVSNGVCSVFLRQEDRSVSIVSEHLAPVLPCNGDEFKIIYGDDRESV 1044
            :. |..|:.::|||||||:|:.|:|||.|:..::.:||..:||.||.|......|:|.|:|||:.
Frog   985 VRDTFQDSQVIGQTGIIRSVTGGLCSVLLQDSEKVISISGDHLEPVTPTKNSRVKVILGEDREAT 1049

  Fly  1045 GRVLSKDGDVFVCR--INEEIKLLPINFLCKMKS 1076
            |.:||.|.:..:.|  :::::|:|.::||.|::|
Frog  1050 GVLLSIDNEDGIVRMDLDDQLKILNLHFLGKLES 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spt5	NP_652610.1	Spt5_N	<136..208	CDD:288770	28/76 (37%)
		nusG	212..352	CDD:181467	102/139 (73%)
		NGN_Euk	215..302	CDD:193577	63/86 (73%)
		KOW_Spt5_1	313..350	CDD:240505	26/36 (72%)
		KOW_Spt5_2	461..511	CDD:240506	31/49 (63%)
		KOW_Spt5_3	512..562	CDD:240507	35/49 (71%)
		KOW_Spt5_4	638..680	CDD:240508	26/41 (63%)
		KOW_Spt5_5	737..788	CDD:240509	34/50 (68%)
		CTD	812..908	CDD:215026	57/110 (52%)
		CTD	812..870	CDD:289577	34/59 (58%)
		KOW_Spt5_6	1020..1075	CDD:240510	21/56 (38%)
supt5h	XP_012823543.1	Spt5_N	72..169	CDD:371811	42/98 (43%)
		NGN_Euk	176..263	CDD:193577	63/86 (73%)
		KOW_Spt5_1	274..311	CDD:240505	26/36 (72%)
		SPT5	332..828	CDD:227493	298/503 (59%)
		DUF5585	<725..>974	CDD:375359	118/255 (46%)
		KOW_Spt5_6	1025..1081	CDD:240510	20/55 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	536	1.000	Domainoid score	I276
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2384
Inparanoid	1	1.050	1093	1.000	Inparanoid score	I243
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166902at33208
OrthoFinder	1	1.000	-	-		FOG0003457
OrthoInspector	1	1.000	-	-		oto102390
Panther	1	1.100	-	-	LDO	PTHR11125
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1387
SonicParanoid	1	1.000	-	-		X2825
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190