DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pont and RVB2

DIOPT Version :9

Sequence 1:	NP_652608.1	Gene:	pont / 53439	FlyBaseID:	FBgn0040078	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_015089.1	Gene:	RVB2 / 855841	SGDID:	S000006156	Length:	471	Species:	Saccharomyces cerevisiae

Alignment Length:	446	Identity:	183/446 - (41%)
Similarity:	284/446 - (63%)	Gaps:	22/446 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 IAAHSHVKGLGLDEVGAAVHSAAGLVGQKAAREAAGIVVDLIKSKKMAGRALLLAGPPGTGKTAI 79
            ||||||:.||||||......::.|:|||..||.|||:::.::::..:||||:|:||||.|||||:
Yeast    20 IAAHSHITGLGLDENLQPRPTSEGMVGQLQARRAAGVILKMVQNGTIAGRAVLVAGPPSTGKTAL 84

  Fly    80 ALAIAQELGNKVPFCPMVGSEVFSNEIKKTEVLMENFRRSIGLRIRETKEVYEGEVTELTPVETE 144
            |:.::|.||..|||..:.|||:||.|:.|||.|.:.||:|||::|:|..|:.||||.|   ::.:
Yeast    85 AMGVSQSLGKDVPFTAIAGSEIFSLELSKTEALTQAFRKSIGIKIKEETELIEGEVVE---IQID 146

  Fly   145 NPM-GGY--GKTISNVVIGLKTAKGTKQLKLDPSIFDALQKEKVEVGDVIYIEANSGAVKRQGRS 206
            ..: ||:  ||      :.:||.......:|...:.|.|.||||..||||.|:..||.:.:.|||
Yeast   147 RSITGGHKQGK------LTIKTTDMETIYELGNKMIDGLTKEKVLAGDVISIDKASGKITKLGRS 205

  Fly   207 DTFATEFDL--ETEEYVPLPKGDVHKKKEVIQDVTLHDLDVANARPQGGQDVLSMMGQLMKPKKT 269
            ...:.::|.  ....:|..|:|::.|:|.|:..|:||::||.|:|.||       ...|......
Yeast   206 FARSRDYDAMGADTRFVQCPEGELQKRKTVVHTVSLHEIDVINSRTQG-------FLALFTGDTG 263

  Fly   270 EITDKLRMEINKVVNKYIDQGIAELVPGVLFIDEIHMLDLETFTYLHKSLESPIAPIVIFATNRG 334
            ||..::|.:||..|.::.::|.||:|||||||||:||||:|.|::::::||...||||:.|||||
Yeast   264 EIRSEVRDQINTKVAEWKEEGKAEIVPGVLFIDEVHMLDIECFSFINRALEDEFAPIVMMATNRG 328

  Fly   335 RCVIRGTTDIVSPHGIPLDLLDRLLIIRTLLYSTADMEQIIKLRAQTEGLQLEENAFTRLSEIGT 399
            ....|| |:..||||:|||||||.:||.|..|:..:::.|:.:|||.|.::|..:|...|::.|.
Yeast   329 VSKTRG-TNYKSPHGLPLDLLDRSIIITTKSYNEQEIKTILSIRAQEEEVELSSDALDLLTKTGV 392

  Fly   400 SSTLRYAVQLLTPAHQMCKVNGRNQISKDDIEDVHSLFLDAKRSSKHLSEKNNKFM 455
            .::|||:..|::.|.|:......|.:..:|::..:.||||:.||.|::.|..::::
Yeast   393 ETSLRYSSNLISVAQQIAMKRKNNTVEVEDVKRAYLLFLDSARSVKYVQENESQYI 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pont	NP_652608.1	TIP49	14..413	CDD:283678	171/402 (43%)
		P-loop_NTPase	40..>80	CDD:304359	22/39 (56%)
		P-loop_NTPase	66..>110	CDD:304359	24/43 (56%)
RVB2	NP_015089.1	TIP49	4..448	CDD:224145	183/444 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1224
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810