DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pont and ruvbl2

DIOPT Version :9

Sequence 1:	NP_652608.1	Gene:	pont / 53439	FlyBaseID:	FBgn0040078	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_777285.1	Gene:	ruvbl2 / 317678	ZFINID:	ZDB-GENE-030109-1	Length:	463	Species:	Danio rerio

Alignment Length:	456	Identity:	199/456 - (43%)
Similarity:	304/456 - (66%)	Gaps:	15/456 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KIEEVKSTVRTQRIAAHSHVKGLGLDEVGAAVHSAAGLVGQKAAREAAGIVVDLIKSKKMAGRAL 66
            |:.||:...|.:||.||||::|||||:.......:.|:|||.|:|.|||:::::||..::||||:
Zfish     9 KVPEVRDITRIERIGAHSHIRGLGLDDALEPRQVSQGMVGQLASRRAAGLILEMIKDGQIAGRAV 73

  Fly    67 LLAGPPGTGKTAIALAIAQELGNKVPFCPMVGSEVFSNEIKKTEVLMENFRRSIGLRIRETKEVY 131
            |:||.|||||||||:.|||.||...||..:.|||:||.|:.|||.|.:.||::||:||:|..|:.
Zfish    74 LIAGQPGTGKTAIAMGIAQSLGPDTPFTALAGSEIFSLEMSKTEALSQAFRKAIGVRIKEETEII 138

  Fly   132 EGEVTELTPVETENPMGGYGKTISNVVIGLKTAKGTKQLKLDPSIFDALQKEKVEVGDVIYIEAN 196
            ||||.|   ::.:.|..|.|..:..:.  |||.:......|...:.::|.||:|:.||||.|:..
Zfish   139 EGEVVE---IQIDRPATGTGAKVGKLT--LKTTEMETIYDLGTKMIESLSKERVQAGDVITIDKA 198

  Fly   197 SGAVKRQGRSDTFATEFDL--ETEEYVPLPKGDVHKKKEVIQDVTLHDLDVANARPQGGQDVLSM 259
            :|.:.:.|||.|.|.::|.  ...::|..|:|::.|:|||:..|:||::||.|:|.||
Zfish   199 TGKISKLGRSFTRARDYDAMGAQTQFVQCPEGELQKRKEVVHTVSLHEIDVINSRTQG------- 256

  Fly   260 MGQLMKPKKTEITDKLRMEINKVVNKYIDQGIAELVPGVLFIDEIHMLDLETFTYLHKSLESPIA 324
            ...|......||..::|.:||..|:::.::|.||::||||||||:||||:|.|::|:::|||.::
Zfish   257 FLALFSGDTGEIKSEVREQINAKVSEWREEGKAEIIPGVLFIDEVHMLDIECFSFLNRALESDLS 321

  Fly   325 PIVIFATNRGRCVIRGTTDIVSPHGIPLDLLDRLLIIRTLLYSTADMEQIIKLRAQTEGLQLEEN 389
            |::|.|||||...||| |:..||||||:|:|||||||.|..|:..:..||:|:|.:.|.::|.|.
Zfish   322 PVLIMATNRGITRIRG-TNYQSPHGIPIDMLDRLLIIATTPYTEKETRQILKIRCEEEDVELSEE 385

  Fly   390 AFTRLSEIGTSSTLRYAVQLLTPAHQMCKVNGRNQISKDDIEDVHSLFLDAKRSSKHLSEKNNKF 454
            |.|.|:.||..::||||:||::.|..:|:.....::..:||:.|:|||||..|||:::.|..:.|
Zfish   386 AHTVLTRIGQETSLRYAIQLISTAGLVCRKRRGTEVQVEDIKRVYSLFLDEARSSQYMKEYQDSF 450

  Fly   455 M 455
            :
Zfish   451 L 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pont	NP_652608.1	TIP49	14..413	CDD:283678	180/400 (45%)
		P-loop_NTPase	40..>80	CDD:304359	24/39 (62%)
		P-loop_NTPase	66..>110	CDD:304359	26/43 (60%)
ruvbl2	NP_777285.1	TIP49	21..412	CDD:283678	181/403 (45%)
ruvbl2	NP_777285.1	P-loop_NTPase	73..>117	CDD:304359	26/43 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1224
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D273414at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820