DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pont and rvb1

DIOPT Version :9

Sequence 1:	NP_652608.1	Gene:	pont / 53439	FlyBaseID:	FBgn0040078	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_594783.1	Gene:	rvb1 / 2543227	PomBaseID:	SPAPB8E5.09	Length:	456	Species:	Schizosaccharomyces pombe

Alignment Length:	445	Identity:	302/445 - (67%)
Similarity:	372/445 - (83%)	Gaps:	0/445 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKIEEVKSTVRTQRIAAHSHVKGLGLDEVGAAVHSAAGLVGQKAAREAAGIVVDLIKSKKMAGRA 65
            ::|.|||...|..||..|||:|||||.|.|.......|.:||:.||||.||:.|||||||..|:.
pombe     2 VQISEVKGNGRDNRITTHSHIKGLGLKEDGTCESVGGGFIGQEKAREACGIITDLIKSKKFGGKG 66

  Fly    66 LLLAGPPGTGKTAIALAIAQELGNKVPFCPMVGSEVFSNEIKKTEVLMENFRRSIGLRIRETKEV 130
            :|.||..||||||:|||||||||.||||||||||||:|:||||||.|||||||:||||::|||||
pombe    67 VLFAGGAGTGKTALALAIAQELGPKVPFCPMVGSEVYSSEIKKTEALMENFRRAIGLRVKETKEV 131

  Fly   131 YEGEVTELTPVETENPMGGYGKTISNVVIGLKTAKGTKQLKLDPSIFDALQKEKVEVGDVIYIEA 195
            |||||||:.|.|.|||:||||||||:|::||||.||||||||||||:::||:|:|..||||||||
pombe   132 YEGEVTEMVPEEAENPLGGYGKTISHVLLGLKTHKGTKQLKLDPSIYESLQREQVSTGDVIYIEA 196

  Fly   196 NSGAVKRQGRSDTFATEFDLETEEYVPLPKGDVHKKKEVIQDVTLHDLDVANARPQGGQDVLSMM 260
            |:|||||.||||.:|||||||.|||||:|||:|||:||::|||||||||:||||||||||::|||
pombe   197 NTGAVKRVGRSDAYATEFDLEAEEYVPMPKGEVHKRKEIVQDVTLHDLDIANARPQGGQDIMSMM 261

  Fly   261 GQLMKPKKTEITDKLRMEINKVVNKYIDQGIAELVPGVLFIDEIHMLDLETFTYLHKSLESPIAP 325
            ||||||||||||||||.||||||||||:||||||:||||||||:||||:|.||||:::|||.|:|
pombe   262 GQLMKPKKTEITDKLRGEINKVVNKYIEQGIAELIPGVLFIDEVHMLDIECFTYLNQALESTISP 326

  Fly   326 IVIFATNRGRCVIRGTTDIVSPHGIPLDLLDRLLIIRTLLYSTADMEQIIKLRAQTEGLQLEENA 390
            |||||:|||.|.||||.||.:|||||.||||||||:|||.||.:::..|:::||:.|.:.|.:..
pombe   327 IVIFASNRGICTIRGTEDIQAPHGIPTDLLDRLLIVRTLPYSESEIRSILQIRAKVENIILTDEC 391

  Fly   391 FTRLSEIGTSSTLRYAVQLLTPAHQMCKVNGRNQISKDDIEDVHSLFLDAKRSSK 445
            ..:|::.|:.::|||.:|||||...:..::|..:|...|||:.:.|||||:||::
pombe   392 LDKLAQEGSRTSLRYVIQLLTPVSIIASLHGNKEIGVQDIEECNDLFLDARRSAQ 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pont	NP_652608.1	TIP49	14..413	CDD:283678	284/398 (71%)
		P-loop_NTPase	40..>80	CDD:304359	25/39 (64%)
		P-loop_NTPase	66..>110	CDD:304359	35/43 (81%)
rvb1	NP_594783.1	TIP49	1..456	CDD:224145	302/445 (68%)
rvb1	NP_594783.1	AAA	41..>131	CDD:99707	67/89 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	555	1.000	Domainoid score	I38
eggNOG	1	0.900	-	-		E1_COG1224
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37839
Inparanoid	1	1.050	622	1.000	Inparanoid score	I149
OMA	1	1.010	-	-		QHG53734
OrthoFinder	1	1.000	-	-		FOG0004646
OrthoInspector	1	1.000	-	-		oto101426
orthoMCL	1	0.900	-	-		OOG6_101792
Panther	1	1.100	-	-	LDO	PTHR11093
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1271
SonicParanoid	1	1.000	-	-		X3263
TreeFam	1	0.960	-	-
	14	13.860