DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ4 and RECQL5

DIOPT Version :9

Sequence 1:	NP_652607.1	Gene:	RecQ4 / 53438	FlyBaseID:	FBgn0040290	Length:	1579	Species:	Drosophila melanogaster
Sequence 2:	XP_005257875.1	Gene:	RECQL5 / 9400	HGNCID:	9950	Length:	1012	Species:	Homo sapiens

Alignment Length:	437	Identity:	144/437 - (32%)
Similarity:	217/437 - (49%)	Gaps:	79/437 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   835 SQHGGVKPLYDLLPDGSVQDTTPEVLEALHMFGHTNFRKG-QDRAIMRTLSGLSSL-VTLSTGSG 897
            |.|....| :|  |:..|:.|..:|      ||..:|:.. |:.|.|..:.|...: |.:.||:|
Human     2 SSHHTTFP-FD--PERRVRSTLKKV------FGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAG 57

  Fly   898 KSLCYQLPAYLYSRKVGAITLVISPLVSLMEDQVTGVPHFL----RAHCLHTNQTAPQRMKIQQM 958
            |||||||||.|    ...||:|:|||::|::||   |.|.|    |...|::..:|.:|   :::
Human    58 KSLCYQLPALL----AKGITIVVSPLIALIQDQ---VDHLLTLKVRVSSLNSKLSAQER---KEL 112

  Fly   959 IANGEID-----ILLVSPE-AVVAGERATGFGAILRQLPPIAFACIDEAHCVSQWSHNFRPSYLM 1017
            :|:.|.:     ||.::|| |..:..:.|....:.|.|  :::..:|||||||||.|:|||.||.
Human   113 LADLEREKPQTKILYITPEMAASSSFQPTLNSLVSRHL--LSYLVVDEAHCVSQWGHDFRPDYLR 175

  Fly  1018 ICKVLRKNLGVRTVLGLTATATLPTRVSIINHLGISDGERGIISDIPLP---DNLVLSVSKDE-- 1077
            : ..||..||....:.||||||...:..:...|.:    :..::....|   .||...|...|
Human   176 L-GALRSRLGHAPCVALTATATPQVQEDVFAALHL----KKPVAIFKTPCFRANLFYDVQFKELI 235

  Fly  1078 -----NRDAALLQLLNSERFEPCQSI-IIYCTRRDECERIAGFIRTCVQDRREPTQDQTKKRKRV 1136
                 |.....|:.|..|..:..... |:||..|:.||::| ...:|               :.|
Human   236 SDPYGNLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLA-IELSC---------------RGV 284

  Fly  1137 NWQAEPYHAGMPASRRRTVQKAFMSNELRIVVATIAFGMGINKPDIRAVIHYNMPRNFESYVQEI 1201
            |  |:.||||:.||.|..||..:|..::.::||||:||||::|.::|.|.|:|:.::...|.||.
Human   285 N--AKAYHAGLKASERTLVQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQES 347

  Fly  1202 GRAGRDGLPSHCHLFLDAKGGDQSELRRHVYSNSIDRHVIRKLLQKI 1248
            |||||||.||.|.|:......||...            :|||.:.|:
Human   348 GRAGRDGKPSWCRLYYSRNDRDQVSF------------LIRKEVAKL 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ4	NP_652607.1	RecQL4_SLD2_NTD	9..55	CDD:421279
RecQ4	NP_652607.1	RecQ	864..>1218	CDD:223588	130/376 (35%)
RECQL5	XP_005257875.1	DEXDc	22..229	CDD:214692	77/229 (34%)
		DEAD	31..201	CDD:278688	69/182 (38%)
		HELICc	246..362	CDD:238034	50/133 (38%)
		RecQ_Zn_bind	367..434	CDD:292742	6/28 (21%)
		RecQ5	625..826	CDD:284397
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820