Protein Alignment RecQ4 and HRQ1

DIOPT Version :10

• Sequence 1: NP_652607.1
• Gene: RecQ4 / 53438
• FlyBaseID: FBgn0040290
• Length: 1579
• Species: Drosophila melanogaster
• Sequence 2: NP_010577.3
• Gene: HRQ1 / 851885
• SGDID: S000002699
• Length: 1077
• Species: Saccharomyces cerevisiae
• Alignment Length: 588
• Identity: 124/588 - (21%)
• Similarity: 219/588 - (37%)
• Gaps: 148/588 - (25%)

  Fly   748 DELNESEEDDQ-------------ESSGDEEVQQHPDPNWSSDEMDVDFEALDAAVEASLSQPVS 799
            |:.|::::..|             ..|..:...|...|.::::||.......:|..::.|.:.:.
Yeast   119 DDQNQTQKSTQLLIFEFIDGTMQRSWSASDRFSQIKIPTYTTEEMKKMISKREALFKSRLREFIL 183

  Fly   800 QEKAA-----SPIKTYVGHKIPEEFLKQAGLDTTASSSNRSQHGGVKPLYDLLPDGSVQDTTPEV 859
            :::.|     |.:.......||.|...:..::....:...|....: |.|.   :.||..|.|::
Yeast   184 EKEKANLDPFSELTNLAQKYIPRERDYEDPIEAMMKAKQESNEMSI-PNYS---NNSVITTIPQM 244

  Fly   860 LEAL-----------HMF------------------------GHTNFRKGQDRAIMRTLSGLSSL 889
            :|.|           |.|                        .|.||...|..||.....|.:.:
Yeast   245 IEKLKSTEFYASQIKHCFTIPSRTAKYKGLCFELAPEVYQGMEHENFYSHQADAINSLHQGENVI 309

  Fly   890 VTLSTGSGKSLCYQLPAY-LYSRKVGAITLVISPLVSLMEDQ-------VTGVPHFLRAHC-LHT 945
            :|.||.|||||.|||.|. |..:...:..:.|.|..:|.:||       ::.:|....|.. .:.
Yeast   310 ITTSTSSGKSLIYQLAAIDLLLKDPESTFMYIFPTKALAQDQKRAFKVILSKIPELKNAVVDTYD 374

  Fly   946 NQTAPQRMKIQQMIANGEIDILLVSPEAVVAGERATGFGAILRQ-------LPPIAFACIDEAHC 1003
            ..|.|:    ::........::..:|:.:        ..:||..       |..:....:||.|.
Yeast   375 GDTEPE----ERAYIRKNARVIFTNPDMI--------HTSILPNHANWRHFLYHLKLVVVDELHI 427

  Fly  1004 VSQ--WSH--NFRPSYLMICKVLRKNLGVRTVLGLTATATLPT------------RVSIINHLGI 1052
            ...  .||  ......|.:|....:|.|::.:   :.:|||.:            .|::|:..|.
Yeast   428 YKGLFGSHVALVMRRLLRLCHCFYENSGLQFI---SCSATLKSPVQHMKDMFGINEVTLIHEDGS 489

  Fly  1053 SDGERGIISDIP--LPDNLVLSVSKDEN--RDAA--LLQL-LNSERFEPCQSIIIYCTRRDECER 1110
            ..|.:.::...|  ||.:    ..|.||  |::|  |:|| ||:.|      .|.:|..|..||.
Yeast   490 PTGAKHLVVWNPPILPQH----ERKRENFIRESAKILVQLILNNVR------TIAFCYVRRVCEL 544

  Fly  1111 IAGFIRTC-VQDRREPTQDQTKKRKRVNWQAEPYHAGMPASRRRTVQKAFMSNELRIVVATIAFG 1174
            :...:|.. ::..||....:...          |..|..||.||.:::......|:.|::|.|..
Yeast   545 LMKEVRNIFIETGREDLVTEVMS----------YRGGYSASDRRKIEREMFHGNLKAVISTNALE 599

  Fly  1175 MGINKPDIRAVIHYNMPRNFESYVQEIGRAGRDGLPSHCHLFLDAKGGDQSELRRHVYSNS-IDR 1238
            :||:...:.||:....|.:..::.|:.|||||               .:...|...|.|:| :|:
Yeast   600 LGIDIGGLDAVLMCGFPLSMANFHQQSGRAGR---------------RNNDSLTLVVASDSPVDQ 649

  Fly  1239 HVI 1241
            |.:
Yeast   650 HYV 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RecQ4	NP_652607.1	RecQL4_SLD2_NTD	9..55	CDD:412085
		RecQ	855..>1216	CDD:440280	98/435 (23%)
HRQ1	NP_010577.3	YprA	239..1018	CDD:440818	104/464 (22%)