DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ4 and RECQ4B

DIOPT Version :9

Sequence 1:	NP_652607.1	Gene:	RecQ4 / 53438	FlyBaseID:	FBgn0040290	Length:	1579	Species:	Drosophila melanogaster
Sequence 2:	NP_176289.7	Gene:	RECQ4B / 842384	AraportID:	AT1G60930	Length:	1150	Species:	Arabidopsis thaliana

Alignment Length:	1235	Identity:	267/1235 - (21%)
Similarity:	447/1235 - (36%)	Gaps:	395/1235 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 EYRQLSKRRKIVSTASGKVEVAAPVEIPNKVEPETE-------------TFAQENPDFSADEDQD 467
            |.::|.:.|::   |:..:|..|||.:.....|:.|             |:.:  |..:...|.|
plant    71 ESQKLGRDREM---AARSIENIAPVTVQTLARPQIEKAWCTLINLSINNTYLR--PGITPAIDND 130

  Fly   468 ATYVPENKKKDKAKRKQAAGKQKTTKPKAEP-KPKTEKKAKVKAEKKPK-AEKKPRNSKKAIAVE 530
            :|                   .:|:..|... |..:.......|...|: :::..|.:.|:|
plant   131 ST-------------------SRTSSTKGSTFKVTSNADGSFCAHNHPEHSQRSVRGTAKSI--- 173

  Fly   531 PAPDPEEDERQPLNPEDLKYVLALEAGDITSVPRINVQDLEEADATAQRYIRTFAAGPNPGLSEG 595
                   |.....:..|.|.:       |..|||:|.:..:....|                 .|
plant   174 -------DSFSSSSVGDNKII-------IDKVPRVNYEVRDSVTVT-----------------NG 207

  Fly   596 SNIRVDEKRAAARKKLEER-IAAGKLNENFV--TINIQK----------------KKFVRGKKSV 641
            ..:...:..|...:.:|.| ::.|:::.:.:  .|::.:                .|||    .:
plant   208 MEMPPIKNSAQLARPVEPREVSLGEIDYDDIMEIIDVDQIAMEHCPSTCTKQPSVSKFV----DI 268

  Fly   642 NFSKYKKQQWRHKKRVAALSGPDMDMGGCDGGVLTCFQCGGVGHFAQQCKVKGDSLLPLSAQLEE 706
            ..|:.:::|          ..|......|..|:.... |.......:|.|   |:||.:|.::.:
plant   269 FTSRREEEQ----------GLPPEICSNCSHGIKLGL-CPEASTHVEQMK---DTLLAISNEILD 319

  Fly   707 D-----PSPFPTLAE----AQEMASQGAVVAHSRNISR---------------LPQAANAAILQG 747
            :     |.....|.:    .::...|..::.|::...:               .||..|..::.|
plant   320 NTYDLGPDHVEQLHQKRLLLKKQIQQLEILIHNKERKKSQCLVSIPSHNTQYETPQTTNLEVVYG 384

  Fly   748 DELNESEEDDQESSGDEEVQQHPDPNWSSDEMDVDFEALDAAVEASLSQPVSQEKAASPIKTYVG 812
                   :.|..:...|:.:...| ||:
plant   385 -------QTDSPTHVKEQGRCVTD-NWN------------------------------------- 404

  Fly   813 HKIPEEFL-KQAGLDTTASSSNRSQHGGVKPLYDLLPDGSVQD-----------TTPEVLEALHM 865
              :|.::| .:...|.::.|..|.|  .|..:.|:....|..|           ...||...| :
plant   405 --MPRDYLVSKERYDISSGSEEREQ--SVSEVIDVTDTESSNDKKWTSSDFPWTKNLEVYNKL-V 464

  Fly   866 FGHTNFRKGQDRAIMRTLSGLSSLVTLSTGSGKSLCYQLPAYLYSRKVGAITLVISPLVSLMEDQ 930
            ||:.:||..|...|..|:||....|.:.||.||||.|||||.|    ...|||||||||||::||
plant   465 FGNHSFRPNQREIINATMSGCDVFVLMPTGGGKSLTYQLPALL----CAGITLVISPLVSLIQDQ 525

  Fly   931 VTGVPHFLRAHCLHTNQTA---------PQRMKIQQMIAN--GEIDILLVSPEAVVAGERATGFG 984
            :..:        |.||.:|         .::::|.|.:::  .:..:|.|:||.|...|......
plant   526 IMNL--------LQTNISAASLSAGMEWAEQLEILQELSSEKSKYKLLYVTPEKVAKSESLLRHL 582

  Fly   985 AILRQLPPIAFACIDEAHCVSQWSHNFRPSYLMICKVLRKNLGVRTVLGLTATATLPTRVSIINH 1049
            .||.....:|...||||||||||.|:|||.|..: .||::......:|.||||||...:..::..
plant   583 EILNSRSLLARFVIDEAHCVSQWGHDFRPDYQGL-GVLKQKFPNIPMLALTATATTSVKEDVVQA 646

  Fly  1050 LGISDGERGIISDIPLPD-----NLVLSVSKDENRDAA-LLQLLNSERFEPCQSIIIYCTRRDEC 1108
            |       |:::.:....     ||..||....|:... :.:.:....|:.|.  ||||..|.:|
plant   647 L-------GLVNCVVFRQSFNRPNLWYSVVPKTNKCLEDIDKFIRENHFDECG--IIYCLSRMDC 702

  Fly  1109 ERIAGFIRTCVQDRREPTQDQTKKRKRVNWQAEPYHAGMPASRRRTVQKAFMSNELRIVVATIAF 1173
            |::...:|.                  ...:|..||..|...:|..|||.:..:|:.|:.||:||
plant   703 EKVTEALRV------------------FGHKAAFYHGSMDPGKRAFVQKQWSKDEINIICATVAF 749

  Fly  1174 GMGINKPDIRAVIHYNMPRNFESYVQEIGRAGRDGLPSHCHLF-----------LDAKGG----- 1222
            ||||||||:|.|||:::|::.|.|.||.|||||||..|.|.|:           :.::||
plant   750 GMGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDGQRSSCVLYYSYTDYIRVKHMISQGGLGQGQ 814

  Fly  1223 ------------------DQSELRRHVY-SNSIDRHVIRKLLQKIFV-------PC--SCDKEAS 1259
                              .::.||...| .|.:|   .|:.||.:.:       .|  :||..:|
plant   815 MKMGYNCKASSGRMLETNTENLLRMVSYCENEVD---CRRFLQLVHLGEKFDSTNCKNTCDNCSS 876

  Fly  1260 KRTALP-------------IPLEG-------------------------DGPRVHMCPGHEIGFS 1286
            .:..:.             :.|.|                         |...:|....|.....
plant   877 SKILIDKDVTVIARQLVALVKLTGERFSSAHIVEIYRGSLNQSVKRNRQDTLHLHGAGKHLTKSE 941

  Fly  1287 VEKTVEML---DIPAENISTLLCY------MELDPRWCISVLSSAYVMAKVISYGGPKYLKHAAK 1342
            ..:.:..|   ||.||.:.....|      ::::.....|:||.    .:.|:...|..:| .:|
plant   942 ASRILHYLVTEDILAEGVKKSELYGSVSSLLKVNRSKAASLLSG----GQSITMRFPSTIK-VSK 1001

  Fly  1343 ECPPLAMAIALQIRDKTF------KEDSNIIEFSVTDIAAGIGWNSGVVKYQLKDLEWVKVNGYP 1401
            :....|....:.::..|.      .:|||:               ||::...||:|.    ....
plant  1002 QSKSTANPAKVPLKQTTLPMAKAAPQDSNL---------------SGILLTALKNLR----TDIV 1047

  Fly  1402 KRSPITVSFYDLGFRIKVPGDFTESEIDNALDTLYTRSVKQERTQLIQLQYVAHGLAAVAYSSCG 1466
            |.||      ||.....:.|:.|..||        ::.:.:.:.:|:.:    :||.....|..|
plant  1048 KESP------DLVMAYHIFGNATLKEI--------SKRLPRTKEELLDI----NGLGKAKVSKYG 1094

Fly 1467 1466
plant 1095 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ4	NP_652607.1	RecQL4_SLD2_NTD	9..55	CDD:421279
RecQ4	NP_652607.1	RecQ	864..>1218	CDD:223588	132/381 (35%)
RECQ4B	NP_176289.7	PLN03137	14..1150	CDD:215597	267/1235 (22%)
		DEAD	471..641	CDD:278688	71/182 (39%)
		HELICc	666..792	CDD:238034	53/145 (37%)
		RecQ_Zn_bind	797..874	CDD:292742	13/79 (16%)
		RQC	883..994	CDD:286470	15/114 (13%)
		HRDC	1035..1101	CDD:278967	17/82 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820