DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ4 and AT1G27880

DIOPT Version :9

Sequence 1:	NP_652607.1	Gene:	RecQ4 / 53438	FlyBaseID:	FBgn0040290	Length:	1579	Species:	Drosophila melanogaster
Sequence 2:	NP_174109.2	Gene:	AT1G27880 / 839681	AraportID:	AT1G27880	Length:	911	Species:	Arabidopsis thaliana

Alignment Length:	1151	Identity:	293/1151 - (25%)
Similarity:	465/1151 - (40%)	Gaps:	296/1151 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   459 DFSADEDQDATYVPENKKKDKAKRKQAAGKQKTTKPKAEPKPKTEKKAKVKAEKKPKAEKKPRNS 523
            ||  |.|.|.::|.....:|..    .:...:...|.....|.:.|.....:..||||...|..:
plant     2 DF--DSDSDGSHVSATPPRDSF----PSSPPQLQSPAKHVPPVSRKMTSSSSRSKPKAPTHPPPN 60

  Fly   524 KKAIAVEPAPDPEEDERQPLNPEDLKYVL-----ALEAGDITSVPRI-------NVQDLEE--AD 574
            ....|..|:|.|......||. .:|.:.:     |..:..::|..|:       :|:.|:.  .|
plant    61 PSQEAPVPSPYPPPPPPSPLF-TNLPFRICQSQPARFSSSVSSFSRLCSRASFTSVEKLKSDGVD 124

  Fly   575 ATAQRYIRTFAAGPNPGLSEGSNIRVDEKRAAARKKLEERIAAGKLNENFVTINIQKKKFVRGKK 639
            ...:..:....|.|.....:..|:..|...:...|.:..| :.|....|||.:|:..|   ||||
plant   125 FVPEPPLVEVIAPPKSVRRKPPNLITDTITSPPVKPMVFR-SNGNGEGNFVKLNLNGK---RGKK 185

  Fly   640 --------SVNFSKYKKQQWRHKKRVAALSGPDMDMGGCDGGVLTCFQCGGVGHFAQQCKVKGDS 696
                    |.:.|.|..:..|:||:.|            ||                    .|:|
plant   186 FPSKYKGVSKSRSSYSFRGKRYKKKEA------------DG--------------------DGES 218

  Fly   697 LLPLSAQLEEDPSPFPTLAEAQEMASQGAVVAHSRNISRLPQAANAAILQGDELNESEEDDQESS 761
            ||                                                     |.|.|.|:..
plant   219 LL-----------------------------------------------------EEESDLQKQI 230

  Fly   762 GDEEVQQHPDPNWSSDEMDVDFEALDAAVEASLSQPVSQEKAASPIKTYVGHKIPEEFLKQAGLD 826
            .||                         ....:|   |.|.|...:|
plant   231 EDE-------------------------ANGFIS---SVEDAILAVK------------------ 249

  Fly   827 TTASSSNRSQHGGVKPLYDLLPDGSVQDTTPEVLEALHMFGHTNFRKGQDRAIMRTLSGLSSLVT 891
            |.||..|.::      |.:|                  ::|:.:||.||.:||...|.|.|:::.
plant   250 TEASDENLTK------LLNL------------------VYGYDSFRDGQLQAIKMILGGSSTMLV 290

  Fly   892 LSTGSGKSLCYQLPAYLYSRKVGAITLVISPLVSLMEDQVTGVPHFLRAHCLHTNQTAPQRMKIQ 956
            |.||:|||||||:||.:    :..||||:|||||||.||:..:|..::...|.::|...:..:..
plant   291 LPTGAGKSLCYQIPAMI----LPGITLVVSPLVSLMIDQLKHLPSIIKGGLLSSSQRPEEATETL 351

  Fly   957 QMIANGEIDILLVSPEAVVAGERATGFGAILRQLPPIAFACIDEAHCVSQWSHNFRPSYLMI-CK 1020
            :.:..|.|.:|.||||.::..|    |.::.|....::...:|||||||:|||||||||:.: ..
plant   352 RKLKEGIIKVLFVSPERLLNVE----FLSMFRMSLSVSLVVVDEAHCVSEWSHNFRPSYMRLKAS 412

  Fly  1021 VLRKNLGVRTVLGLTATATLPTRVSIINHLGISDGERGIISDIPLPDNLVLSVS-KDENRDAALL 1084
            :|...|....:|.:|||||..|..::::.|.|.  ...:|....|.||..|||| ...||...||
plant   413 MLFSELKAECILAMTATATTMTLQAVMSSLEIP--STNLIQKSQLRDNFELSVSLSGANRMKDLL 475

  Fly  1085 QLLNSERFEPCQSIIIYCTRRDECERIAGFIRTCVQDRREPTQDQTKKRKRVNWQAEPYHAGMPA 1149
            .|:.|..::..:|||:||..:.|.:.|:.::|           |.       |..|:.||:|:||
plant   476 ILMESPPYKEIRSIIVYCKFQYETDMISKYLR-----------DN-------NINAKGYHSGLPA 522

  Fly  1150 SRRRTVQKAFMSNELRIVVATIAFGMGINKPDIRAVIHYNMPRNFESYVQEIGRAGRDGLPSHCH 1214
            ..|..:|::|.||::|:||||:|||||::|.|:.||||:::|.:.|.||||||||||||..|:||
plant   523 KDRVRIQESFCSNKIRVVVATVAFGMGLDKGDVGAVIHFSVPGSMEEYVQEIGRAGRDGRLSYCH 587

  Fly  1215 LFLDAKGGDQSELRRHVYSNSIDRHVIRKLLQKIFVPCSCDKEASKRTALPIPLEGDGPRVHMCP 1279
            ||.|  .....:||...:|:.:|.:.:.|.|..:|  .:..|:..|..:|.|
plant   588 LFYD--NDTYLKLRSLAHSDGVDEYAVGKFLTHVF--STETKQHEKICSLVI------------- 635

  Fly  1280 GHEIGFSVEKTVEMLDIPAENISTLLCYMELDPRWCISVLSSAYVMAKVISYGGPKYLKHAAKEC 1344
                    |...:..|:..|.:.|:|.::||.....:.:|....:...:      .:.|.:....
plant   636 --------ESASQKFDMKEEVMQTILTHLELGEVQYLRMLPQLNICCTL------NFHKSSPNTL 686

  Fly  1345 PPLAMAIALQIRDKTFKEDSNIIEF---------SVTDIAAGIG--WNSGVVKYQLKDLEWVKVN 1398
            ...:..:|..::....|:..::.:.         :.||:.|.|.  ...|.|.|:|||
plant   687 AARSAIVAAILKKSHVKQGLHVFDIPAVASSICVATTDVLAEIQALKMKGEVTYELKD------- 744

  Fly  1399 GYPKRSPITVSFYDLGFRIKVPGDFTESEIDNALDTLYTRSVKQ-ERTQLIQLQYVAHGLAAVAY 1462
                    :...|.:   :|.|.:..      :|.:..|:.:.: |..::.:|..::.  ||||.
plant   745 --------SAFCYTI---LKSPKEIC------SLSSHLTKWLTEIESCKVRKLDIMSS--AAVAA 790

  Fly  1463 SSCGQCCNADFPQDRGEQLKAIVRNYFANDYPQDLELEIEPSNVPDEN---IIDDVHALINMYPD 1524
            .|............:...|::.:.:||..|...|     .||.. .:|   :..|:...:.....
plant   791 ISVSNTSELSSGAKQTRSLQSRIFDYFNGDEKCD-----SPSKA-TQNCAFLRADIKVFLQSNRQ 849

  Fly  1525 NTFTGRNIARIFHGIMSPNYPAVIWGRCKFWRAHVKVDFNRILHLA 1570
            ..||.|.||||.||:.||.:|..:|.:..||..::.|||..|:..|
plant   850 AKFTPRAIARIMHGVGSPAFPNSVWSKTHFWGRYMNVDFRVIMEAA 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ4	NP_652607.1	RecQL4_SLD2_NTD	9..55	CDD:421279
RecQ4	NP_652607.1	RecQ	864..>1218	CDD:223588	145/355 (41%)
AT1G27880	NP_174109.2	DEAD	271..413	CDD:278688	62/149 (42%)
		AAA	284..412	CDD:214640	56/135 (41%)
		HELICc	484..589	CDD:238034	54/122 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	123	1.000	Domainoid score	I1841
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	314	1.000	Inparanoid score	I726
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	1	1.000	-	-		FOG0007178
OrthoInspector	1	1.000	-	-		oto3363
orthoMCL	1	0.900	-	-		OOG6_105088
Panther	1	1.100	-	-	LDO	PTHR13710
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5288
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830