DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ4 and Recql4

DIOPT Version :9

Sequence 1:	NP_652607.1	Gene:	RecQ4 / 53438	FlyBaseID:	FBgn0040290	Length:	1579	Species:	Drosophila melanogaster
Sequence 2:	XP_006521609.1	Gene:	Recql4 / 79456	MGIID:	1931028	Length:	1267	Species:	Mus musculus

Alignment Length:	1659	Identity:	472/1659 - (28%)
Similarity:	683/1659 - (41%)	Gaps:	496/1659 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KLRVKVWEKDFKKKNGRVPSKYDIRDASQEIRDSYKMYYKLKTSFLEETLNDVLSEDGYDILEMS 78
            :.|::.||:.|.:.:||.|:|.|:..|.:|.|..|:.|..||.:..:       ::|.:.:||.|
Mouse     8 RARLQEWERAFARLHGRRPAKGDVEAAPEETRALYREYRNLKQAVRQ-------ADDRHRVLEQS 65

  Fly    79 QASDFGVSMLDQDVSLNEGPQLPLDISALVGPQSSGNLEEIPQSVEGSFSNLIDLPNRQVLTNLV 143
            .|
Mouse    66 LA--------------------------------------------------------------- 67

  Fly   144 NRDENHVIRKFEAVEELPINQNAWGLNVSKKPPAPPQPVEAS---KSAPGHGKQPKAGASLK--- 202
                       ||.||.. ..:.||.::|:......|.:...   .|...:||:.|  |:||
Mouse    68 -----------EAAEEAQ-EPSCWGPHLSRAATQNTQSMPKQSLLSSVQDYGKRLK--ANLKNTT 118

  Fly   203 ---PSLSAKLFQSSRGFAK-RNPRKPLSRCVS--SSSSTTSLSSVPTDHHEELLDFETILIRKAQ 261
               |:.|.||....|..:. ..||.|.|:..|  ...:..:|..||
Mouse   119 QTGPTQSRKLQLQKRSLSTVPAPRPPGSKTESPCPDEADDALPRVP------------------- 164

  Fly   262 EYKEKQQAIANNPMLASEHSKESIKTLVDDGWLRR--NTKENTLDEEVPFAEANNNSGTSKKTNF 324
               |.:..:.....|.|..|:.  .|.:|.|||.|  |...:.|  |||
Mouse   165 ---EPRPRLGQLQQLRSSLSRR--LTSLDPGWLERCHNRVSDLL--EVP---------------- 206

  Fly   325 GLANLDLSKLKPTVKEEKVLQAKPDQMAIIQELQTDMNSSMNQKPDHLNHTPPASSQKSVAPKNK 389
            |...|||
Mouse   207 GACGLDL---------------------------------------------------------- 213

  Fly   390 PPPSEQETDSDSDSVVAESEEEQEPQEYRQLSKRRKIVSTASGKVEVAAPVEIPNKVEPET-ETF 453
                              |.||.:||              .||||.:|.| :|.::|..:: |..
Mouse   214 ------------------SAEESQPQ--------------MSGKVNIADP-DIQSEVSVQSPEAI 245

  Fly   454 AQENPDFSADEDQDATYVPENKKKDKAKRKQAAGKQKTTKPKAEPKPKTEKKAKVKAEKKPKAEK 518
            ||          |.|..:.::.|...:|.:               |.|..:|.:..|:.:|.:..
Mouse   246 AQ----------QPAQVLSQSPKSINSKGR---------------KRKWNEKGEDFAQDQPSSGA 285

  Fly   519 KPRNSKKAIAVEPAPDPEEDER----QPLNPEDLKYVLALEAGDITSVPRINVQDLEEADATAQR 579
            .|.:......|.....|.|..:    ||.|..                   |....|:|..|...
Mouse   286 GPLSEGARATVHGQDPPGEPTQVNVPQPCNSS-------------------NQARTEKAKGTTHL 331

  Fly   580 YIRTFAAGPNP-GLSEGSNIRVDEKRAAARKKLEERIAAGKLNENFVTINIQKKKFVRGKKSVNF 643
            :     |.|.| .|..|:.||::.|                 |:.||.:...:.:.:|
Mouse   332 H-----ASPRPASLDRGNYIRLNMK-----------------NKRFVRVGANRGRLLR------- 367

  Fly   644 SKYKKQQWRHKKRVAALSGP---DMDMGGCDGGVLTCFQCGGVGHFAQQCKVKGDSLLPLSAQLE 705
            .:..||:|:.|:.....|||   |.|         |||:||..||:|.||...|.:|........
Mouse   368 KQVWKQKWKKKQAAFGGSGPRATDKD---------TCFRCGQFGHWASQCSQPGPTLTVQEEGDR 423

  Fly   706 EDPSPFPTLAEAQEMASQGAVVAHSRNISRLPQAANAAILQGDELNESEEDDQESSGDEEVQQHP 770
            :|..|..||.|..:..  |....|                     :.:.|:.|.::.:.:|...|
Mouse   424 DDKQPISTLEEVAQRT--GTASCH---------------------HSAGEETQPAAPELQVPHCP 465

  Fly   771 DPNWSSDEMDVDFEALDAAVEASLSQPVSQEKAASPIKTYVGHKIPEEFLKQAGLDTTASSSNRS 835
            .|
Mouse   466 TP--------------------------------------------------------------- 467

  Fly   836 QHGGVKPLYDLLPDGSVQDTTPEVLEALHMFGHTNFRKGQDRAIMRTLSGLSSLVTLSTGSGKSL 900
                :.|||...|.|.|.:|..||.:||...|:..||.||:|||||.|||:|:|:.|.||:||||
Mouse   468 ----MSPLYPPGPLGQVAETPAEVFQALERLGYRAFRPGQERAIMRILSGISTLLVLPTGAGKSL 528

  Fly   901 CYQLPAYLYSRKVGAITLVISPLVSLMEDQVTGVPHFLRAHCLHTNQTAPQRMKIQQMIANGEID 965
            ||||||.||:::...:|||:|||:|||:|||:.:|..|:|.|||:..|..||..:.:.:...::.
Mouse   529 CYQLPALLYAQRSPCLTLVVSPLLSLMDDQVSDLPSCLKAACLHSGMTKKQRESVLKKVRAAQVH 593

  Fly   966 ILLVSPEAVV-AGERATGFGAILRQLPPIAFACIDEAHCVSQWSHNFRPSYLMICKVLRKNLGVR 1029
            :|:|||||:| .|.|..|......||||||||||||.||:|||||||||.||.:|||||:::|||
Mouse   594 VLIVSPEALVGCGARGPGSLPQAAQLPPIAFACIDEVHCLSQWSHNFRPCYLRVCKVLREHMGVR 658

  Fly  1030 TVLGLTATATLPTRVSIINHLGISDGERGIISDIPLPDNLVLSVSKDENRDAALLQLLNSERFEP 1094
            ..||||||||..|...:..||||: ||..:.....:|.||.||||.|.:.|.||:.||..:||..
Mouse   659 CFLGLTATATRSTARDVAQHLGIA-GEFELSGSANIPANLHLSVSMDRDSDQALVTLLQGDRFRT 722

  Fly  1095 CQSIIIYCTRRDECERIAGFIRTCVQDRREPTQDQTKKRKRVNWQAEPYHAGMPASRRRTVQKAF 1159
            ..|:|||||||.:.||:|..:|||:    ....|...:.......||.|||||.:..||.||:||
Mouse   723 LDSVIIYCTRRKDTERVAALLRTCL----SMVGDSRPRGCGPEAIAEAYHAGMSSQERRRVQQAF 783

  Fly  1160 MSNELRIVVATIAFGMGINKPDIRAVIHYNMPRNFESYVQEIGRAGRDGLPSHCHLFL------- 1217
            |...||:||||:|||||:::||:|||:|..:|.:||||||.||||||||.|:|||||:
Mouse   784 MRGHLRMVVATVAFGMGLDRPDVRAVLHLGLPPSFESYVQAIGRAGRDGKPAHCHLFMHPQVGSP 848

  Fly  1218 -------------------------------------------DAKGGDQSELRRHVYSNSIDRH 1239
                                                       ..:|.|..|||||.:::|.|..
Mouse   849 ISPDQDRPRGSTIPRPLQPQLLSCLPVSCRPGPKCGSSVHMTVPMQGEDLWELRRHAHADSTDFL 913

  Fly  1240 VIRKLLQKIFVPCSCDKEASKRTALPIPLEGDGPRVH-----MCPGHEIGFSVEKTVEMLDIPAE 1299
            .:::|:|::|.||:|.:....:::.....|..|.:.:     .|.|||....|:.||:.||:..|
Mouse   914 AVKRLVQRVFPPCTCSQRPVSKSSPEEVKEHSGQQTYPVLGQACLGHERALPVQSTVQALDMTEE 978

  Fly  1300 NISTLLCYMELDPRWCISVLSSAYVMAKVISYGGPKYLKHAAKECPPLAMAIALQIR--DKTFKE 1362
            .|.|||||:||.||..:.:|...|....:...||...|:..|..|||||   |.|.:  .|...:
Mouse   979 AIETLLCYLELHPRHWLELLPWTYAQCHLHCLGGSAQLQALAHRCPPLA---ACQAKWPPKDTSQ 1040

  Fly  1363 DSNIIEFSVTDIAAGIGWNSGVVKYQLKDLEWVKVNGYPKR-----SPITVSFYDLGFRIKVPGD 1422
            ..:.:||.|.::|..:||....|:..|..|:|   :..||:     :.:.|.|.:|.|.:...||
Mouse  1041 GRSSLEFGVVELADSMGWKLASVRQALHQLKW---DPEPKKGAAQGTGVLVKFSELAFHLHSRGD 1102

  Fly  1423 FTESEIDNALDTLYTRSVKQERTQLIQLQYVAHGLAAVAYSSCGQCCNADFPQDRGEQLKAIVRN 1487
            .|:.|.|...|.||.|...:|...|..|..::....:||:.|||.|.... .::...|:|.:|..
Mouse  1103 LTDEEKDQICDFLYNRVQAREHKALAHLHQMSKAFRSVAFPSCGPCLEQS-NEEHSNQVKTLVSY 1166

  Fly  1488 YFANDYPQDLELEIEPSNVP--------DENIIDDVHALINMYPDNTFTGRNIARIFHGIMSPNY 1544
            ||..:..::..:.......|        ::.|..||..|:::.|:..|:||.:|||||||.||.|
Mouse  1167 YFEEEEEEEETMTDTQGPKPGQTQLQDWEDQIRRDVRQLLSLRPEERFSGRAVARIFHGIASPCY 1231

  Fly  1545 PAVIWG-RCKFWRAHVKVDFNRILHLANMAIIKR 1577
            ||.::| ..:|||.::.:||:.::|||...::.|
Mouse  1232 PAQVYGLDRRFWRKYLHLDFHALMHLATEELLLR 1265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ4	NP_652607.1	RecQL4_SLD2_NTD	9..55	CDD:421279	14/40 (35%)
RecQ4	NP_652607.1	RecQ	864..>1218	CDD:223588	191/404 (47%)
Recql4	XP_006521609.1	Drc1-Sld2	4..>49	CDD:371692	14/40 (35%)
		ZnF_C2HC	394..408	CDD:197667	8/13 (62%)
		RecQ	483..>844	CDD:223588	196/365 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845553
Domainoid	1	1.000	222	1.000	Domainoid score	I2583
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	633	1.000	Inparanoid score	I838
Isobase	1	0.950	-	0	Normalized mean entropy	S4803
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	1	1.000	-	-		FOG0007178
OrthoInspector	1	1.000	-	-		oto91942
orthoMCL	1	0.900	-	-		OOG6_105088
Panther	1	1.100	-	-	LDO	PTHR13710
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5620
SonicParanoid	1	1.000	-	-		X5288
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.740