Protein Alignment RecQ4 and recql4

DIOPT Version :10

• Sequence 1: NP_652607.1
• Gene: RecQ4 / 53438
• FlyBaseID: FBgn0040290
• Length: 1579
• Species: Drosophila melanogaster
• Sequence 2: NP_001072882.1
• Gene: recql4 / 780344
• XenbaseID: XB-GENE-997814
• Length: 1520
• Species: Xenopus tropicalis
• Alignment Length: 1764
• Identity: 533/1764 - (30%)
• Similarity: 801/1764 - (45%)
• Gaps: 444/1764 - (25%)

  Fly     9 KYQKYKLRVKVWEKDFKKKNGRVPSKYDIRDASQEIRDSYKMYYKLKTSFLEETLNDVLSEDGYD 73
            :|.:.|:.:|.||..|.:::.|.|:|.|:.:||.|.::.||.|..||...|:.:...|.:.....
 Frog     3 RYNQVKVLLKNWETAFLQEHKRRPNKTDVENASNETQELYKEYRSLKQGQLDVSTESVFTPKSGQ 67

  Fly    74 IL--EMSQASDFGVSMLDQDVSLNEGPQL---------------PLDISA-LVGPQSSGNL---- 116
            :.  .:::::|   :..|.:.|.:.|..|               .|..|| ..|.:...||
 Frog    68 VASPRLARSAD---AAGDSEGSASWGSHLNRACVTPKLTPKERDSLKASAQFYGMKLKANLGGAS 129

  Fly   117 EEIPQSVEGSFSNLIDLP-NRQVLTNLVNRDENHV---------IRKFEAVEELPINQNAWGLNV 171
            :|.|.|::.||:     | :|..:.:...:..||:         |...|.:::.|...:....::
 Frog   130 KERPVSLKKSFT-----PRSRPAIGSPDVKTRNHLAFPKPPGTPISPPELLQDTPSEPSDTSSHI 189

  Fly   172 SKKPPAPPQPVEASKSAPG------HGKQPKAGASLKPSLSAKLFQSSRGFAKRNPRKPL----- 225
            |.|.| ||:|. .:.||.|      |..|...|..: .||:.:..|...   .||..:|:
 Frog   190 SLKEP-PPKPA-WNPSALGQPIKKQHQLQAMVGQRM-ASLNQEWLQRCE---LRNGAEPMEVTAA 248

  Fly   226 -------SRCVSSSSSTTSLSSVPTDHHEELLDFETILIRKAQEYKEKQQAIANNPMLASEHSKE 283
                   .:|.|:.......:...||.|                      ..:||...|  ||..
 Frog   249 EQRNVNREQCDSTWEPLAEGAIESTDLH----------------------ITSNNDEFA--HSVT 289

  Fly   284 SIKTLVDDGWLRRNTKENTLDEEVPFAEANNNSGTSKKTNFGLANLDLSKLKPTVKEEKVLQAKP 348
            |....|                 :.|....:....|.........||.|..||   ::|.::. |
 Frog   290 SPTHSV-----------------LAFTPGPSQHAASPSLPLTFGRLDKSPEKP---KQKAVET-P 333

  Fly   349 DQMAIIQELQTDMNSSMNQK-----PDHLNHTPPASSQKSVAPKNKPPPSEQETDSDSDSVVAES 408
            .:.:|::...||..||.|::     ||.             .|..:..|..|....:|.:.:||:
 Frog   334 GRNSIVRSRVTDSVSSRNKREGVWDPDQ-------------QPLERKFPVRQRICVESKASLAEA 385

  Fly   409 EEEQEPQEYRQLSKRRKIVSTASGKVEVAAPVEIPNKVEPETETFAQENPDFSADEDQDATYVPE 473
                ....:.||..:..:.:.:....::.....:.|:..|.     |::|       |:...:|:
 Frog   386 ----GMGAHNQLDSKGPMSNGSKQLQDIDVGQVMKNRTRPR-----QQSP-------QEVDGMPQ 434

  Fly   474 ------------NKKKDKAKRKQAAGKQKTTKPKAEPKPKTEKKAKVKAEKKPKAEKKPRNSKKA 526
                        :|.|.|.::::.:.:|..    .|..||..||.:       |.:..|.|.:|:
 Frog   435 ETIAGGEASAILSKGKRKKRQREISAEQDA----VEESPKVSKKRR-------KTKMSPDNGEKS 488

  Fly   527 IAV-----------EPAPDP------EEDERQPLNPEDLKYVLALEAGDITSVPRINVQDLEEAD 574
            ..|           :.:.||      .|...:|:: |||                  ..:|||
 Frog   489 SPVQNRRKRGARRNDSSDDPSMESPASEQGAKPVS-EDL------------------FGELEE-- 532

  Fly   575 ATAQRYIRTFAAGPNPGLSEGSNIRVDEKRAAARKKLEERIAAGKLNENFVTINIQKKKFVRGKK 639
            .||||                  |.|...:|....:::        :||||.||::||..|: ..
 Frog   533 ETAQR------------------ISVKTAKATRMPQIK--------SENFVRINLKKKSHVK-SF 570

  Fly   640 SVNFSKYKKQQWRHKKRVAALSGPDMDMGG--CDGGVLTCFQCGGVGHFAQQCKVKGDSLLPLSA 702
            ::|..:.:||.|:.|.:   ..|.....||  .:.|..|||:|||:||:|.||    ...:|:..
 Frog   571 ALNGQRLRKQMWKQKWQ---KKGEQFGGGGKHFNRGGDTCFRCGGIGHWASQC----PGSVPVVR 628

  Fly   703 Q-----LEEDPSPFPTLAEAQEMASQGAVVAHSRNISRLPQAANAAILQGDELNESEEDDQESSG 762
            |     .||:....|||.:...|.:           ::| |:.:|.:..|
 Frog   629 QEVVEIEEEEEVSLPTLEDVARMTN-----------TQL-QSTSAEVPSG--------------- 666

  Fly   763 DEEVQQHPDPNWSSDEMDVDFEALDAAVEASLSQPVSQEKAASPIKTYVGHKIPEEFLKQAGLDT 827
                       |....:     |....|.|....|    :..||::.
 Frog   667 -----------WCQGPV-----ATLNVVRAVYEPP----EPPSPMQA------------------ 693

  Fly   828 TASSSNRSQHGGVKPLYDLLPDGSVQDTTPEVLEALHMFGHTNFRKGQDRAIMRTLSGLSSLVTL 892
                           ||:|.|||.|::|..||.:.|...|:::||.||::|:||.||||||||.|
 Frog   694 ---------------LYELEPDGKVKETPAEVYDTLSELGYSSFRPGQEQAVMRILSGLSSLVIL 743

  Fly   893 STGSGKSLCYQLPAYLYSRKVGAITLVISPLVSLMEDQVTGVPHFLRAHCLHTNQTAPQRMKIQQ 957
            |||.|||||||||||:|:::...||||||||||||:|||:|:|..|:|.|:|:|.|..||....:
 Frog   744 STGMGKSLCYQLPAYMYAKRSRCITLVISPLVSLMDDQVSGLPPKLKAVCIHSNMTRTQRETAIE 808

  Fly   958 MIANGEIDILLVSPEAVVAGERATGFGAI--LRQLPPIAFACIDEAHCVSQWSHNFRPSYLMICK 1020
            .:..|::.:||:||||:|.|.: :|...:  ..||||:||||||||||||:|||||||.||.:||
 Frog   809 KVKQGKVHVLLLSPEALVGGGQ-SGSSCLPPAEQLPPVAFACIDEAHCVSEWSHNFRPCYLRLCK 872

  Fly  1021 VLRKNLGVRTVLGLTATATLPTRVSIINHLGISDGERGI-ISDIPLPDNLVLSVSKDENRDAALL 1084
            |||:.|||..:||||||||..|...:..|||:|. |.|| :....:|.||.||||.|.|||.||:
 Frog   873 VLRERLGVNCLLGLTATATRATAEDVARHLGVSQ-EGGIPVRMASVPPNLHLSVSMDRNRDQALV 936

  Fly  1085 QLLNSERFEPCQSIIIYCTRRDECERIAGFIRTCV----------QDRREPTQDQTKK------- 1132
            .||..|||....|:|:|||||:|.:||:..:||.:          |::.|.|....||
 Frog   937 TLLKGERFGCLDSVIVYCTRREETQRISALLRTSLQGVTVSNLNSQEQEEATVSDRKKAQALKKI 1001

  Fly  1133 RKRVNWQAEPYHAGMPASRRRTVQKAFMSNELRIVVATIAFGMGINKPDIRAVIHYNMPRNFESY 1197
            |:.:.|.||.|||||.|:.||.||..||..:||:||||:|||||::|.|:|.:||||||:|||||
 Frog  1002 RRPLKWIAESYHAGMSAAERRRVQNNFMCGQLRLVVATVAFGMGLDKSDVRGIIHYNMPKNFESY 1066

  Fly  1198 VQEIGRAGRDGLPSHCHLFLDAKGGDQSELRRHVYSNSIDRHVIRKLLQKIFVPCS--------- 1253
            |||||||||||..:.||||||.:..|..|||||:||:|:|...:::|:||:|..|.
 Frog  1067 VQEIGRAGRDGKDAQCHLFLDPEEHDMDELRRHIYSDSVDCITVKRLVQKVFPKCKCRDLEREQQ 1131

  Fly  1254 --------------------------------------CDKEASKRTAL---------PI---PL 1268
                                                  ||..:|.|..:         |:   |:
 Frog  1132 ALTNAGEVEDSELLEFLAQSGEEQDGMCDTPSSGTDPVCDTPSSGRDPVCDTPVSGRDPVCDTPI 1196

  Fly  1269 EGDGPRV---HMCPGHEIGFSVEKTVEMLDIPAENISTLLCYMELDPRWCISVLSSAYVMAKVIS 1330
            .|..|.:   .:|..||....:|:||:.|||..|.|.|||||:||.|...:..:.......:|:.
 Frog  1197 IGRDPSMRTPRLCHRHERAIPIEETVQGLDIREEAIETLLCYLELHPSHWLEQMHPTLSHCRVVC 1261

  Fly  1331 YGGPKYLKHAAKECPPLAMAIALQIRDKTFKEDS---NIIEFSVTDIAAGIGWNSGVVKYQLKDL 1392
            |.||:.|:..|..|||:|:.:|   |::....|.   :.:||:|.::|..:||....||..|:||
 Frog  1262 YSGPQQLRQLASSCPPVAVCLA---RERLAGVDHTHVSSVEFNVVELADSMGWEMVPVKRALRDL 1323

  Fly  1393 EW-------VKVNGYPKRSPITVSFYDLGFRIKVPGDFTESEIDNALDTLYTRSVKQERTQLIQL 1450
            :|       .|..|   ||.:.|.|..|.|..:..||.|:.|:|...|.|:.:...:|||.|.||
 Frog  1324 QWKQQPERGFKGTG---RSGVLVEFGRLSFHFRSYGDLTDQELDEVCDFLHQKVTSRERTSLNQL 1385

  Fly  1451 QYVAHGLAAVAYSSCGQCCNADFPQDRGEQLKAIVRNYFANDYPQDLELEIEPSNVPDENIID-- 1513
            :.......:|||.:...|.. ....:|..||||::..||.....::.::|     .|||.:.:
 Frog  1386 KSCFRAFQSVAYRTSSACAE-QISAERSAQLKALLWEYFEKRVTEEAKVE-----DPDEELREIK 1444

  Fly  1514 ----------DVHALINMYPDNTFTGRNIARIFHGIMSPNYPAVIWGR-CKFWRAHVKVDFNRIL 1567
                      |:...::::.:..|:||.:|||||||.||.|||.::|| .:|||.::.:|||.::
 Frog  1445 LQESKDQVRSDIRHFLSIHQEERFSGRALARIFHGIGSPCYPAQVFGRDRRFWRKYIHLDFNELM 1509

  Fly  1568 HLANMAIIK 1576
            :|:...||:
 Frog  1510 NLSKEEIIR 1518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RecQ4	NP_652607.1	RecQL4_SLD2_NTD	9..55	CDD:412085	16/45 (36%)
		RecQ	855..>1216	CDD:440280	209/380 (55%)
recql4	NP_001072882.1	RecQL4_SLD2_NTD	2..50	CDD:412085	17/46 (37%)
		Atrophin-1	<158..232	CDD:460830	18/76 (24%)
		ZnF_C2HC	606..621	CDD:197667	11/18 (61%)
		RecQ	708..1178	CDD:440280	230/471 (49%)