back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ4 and BLM

DIOPT Version :10

Sequence 1:	NP_652607.1	Gene:	RecQ4 / 53438	FlyBaseID:	FBgn0040290	Length:	1579	Species:	Drosophila melanogaster
Sequence 2:	NP_000048.1	Gene:	BLM / 641	HGNCID:	1058	Length:	1417	Species:	Homo sapiens

Alignment Length:	1155	Identity:	287/1155 - (24%)
Similarity:	445/1155 - (38%)	Gaps:	272/1155 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 SLSAKLFQSSRGFAKRNPRKPLSRCVSSSSSTTSLSSVPTDHHEELLDFETILIRKAQEYKEKQQ 268
            :|:.||..|...|:....:|..|...:.|.:..|::..|...::::...|.....:.......||
Human    20 TLNNKLSLSKPKFSGFTFKKKTSSDNNVSVTNVSVAKTPVLRNKDVNVTEDFSFSEPLPNTTNQQ 84

  Fly   269 AIAN---NPMLASEHSKESIKTLVDDGWLRRNTKENTLDEEVPFAEANNNSGTSKKTNFGLANLD 330
            .:.:   |.....|..:...|:|:.|  ..:..||...        ...|:.|.||:.    :..
Human    85 RVKDFFKNAPAGQETQRGGSKSLLPD--FLQTPKEVVC--------TTQNTPTVKKSR----DTA 135

  Fly   331 LSKLKPTVKEEKVLQAKPDQMAIIQELQTDMNSSMNQKPDHLNHTPPASS--QKSVAPKNK---- 389
            |.||:        ..:.||.::.|.:.. ||:.....:......|||.|.  :.|.|.|:|
Human   136 LKKLE--------FSSSPDSLSTINDWD-DMDDFDTSETSKSFVTPPQSHFVRVSTAQKSKKGKR 191

  Fly   390 -----------------PPPS----------EQETDSD---------SDSVVAE---SEEEQEP- 414
                             ||||          ||:.||:         .|..:||   :|:.||.
Human   192 NFFKAQLYTTNTVKTDLPPPSSESEQIDLTEEQKDDSEWLSSDVICIDDGPIAEVHINEDAQESD 256

  Fly   415 ------QEYRQLSKRRKIVSTASGKVEVAAPVEIPNKVEPETETFAQENPDFSADEDQDATYVPE 473
                  ::.|..|:::|.:..|    |:.:..::| .:|.:             |:|.|..:||.
Human   257 SLKTHLEDERDNSEKKKNLEEA----ELHSTEKVP-CIEFD-------------DDDYDTDFVPP 303

  Fly   474 NKKK-----DKAKRKQAAGKQKTTKPKAEPKPKTEKKAKVKAEKKPKAEKKPRNSKKAIAVEPAP 533
            :.::     ..:.:..:..|...|..:.|....|.|....|.||....|..|..|...
Human   304 SPEEIISASSSSSKCLSTLKDLDTSDRKEDVLSTSKDLLSKPEKMSMQELNPETSTDC------- 361

  Fly   534 DPEEDERQPLNPEDLKYVLALEAGDITSVPRINVQDLEEADATAQRYIRTFAAGPNPGLSEGSNI 598
                |.||....:.|.:|:......|.::|...::.|:..:...|:                .||
Human   362 ----DARQISLQQQLIHVMEHICKLIDTIPDDKLKLLDCGNELLQQ----------------RNI 406

  Fly   599 RVDEKRAAARKKLEERIAAGKLNENFVTINIQKKKFVRGKKSVNFSKYKK----QQWRHKKRVAA 659
            |        ||.|.|                           |:|:|...    ..||:  |..:
Human   407 R--------RKLLTE---------------------------VDFNKSDASLLGSLWRY--RPDS 434

  Fly   660 LSGPDMDMGGCDGGVLTCFQCGGVGHFAQQCKVKGDSLLPLS----------AQLEEDPSPFPTL 714
            |.|| |:...|..|  ...:.....|........||.||..:          ..|.|.|. |.|.
Human   435 LDGP-MEGDSCPTG--NSMKELNFSHLPSNSVSPGDCLLTTTLGKTGFSATRKNLFERPL-FNTH 495

  Fly   715 AEAQEMASQGAVVAHSRNISRLPQAANAAILQGDELNESEEDDQ--ESSGDEEVQQHPDPNWSSD 777
            .:...::|..|      ...||.:...::...|:.|..:...||  .::...::::...|::..|
Human   496 LQKSFVSSNWA------ETPRLGKKNESSYFPGNVLTSTAVKDQNKHTASINDLERETQPSYDID 554

  Fly   778 EMDV-DFEALD---------AAVEASLS--QPVSQEKAASPIKTYVGHKIPEEFLKQAGLD---- 826
            ..|: ||:..|         ||.::|.:  ||:   |...|||:.      .|.|..|..|
Human   555 NFDIDDFDDDDDWEDIMHNLAASKSSTAAYQPI---KEGRPIKSV------SERLSSAKTDCLPV 610

  Fly   827 -TTASSSNRSQHGGVKPLYDLLPDGSVQDT-----------------TPEVLEALH-MFGHTNFR 872
             :||.:.|.|:.      .....|.|.|:.                 |.|:::..| .||..|||
Human   611 SSTAQNINFSES------IQNYTDKSAQNLASRNLKHERFQSLSFPHTKEMMKIFHKKFGLHNFR 669

  Fly   873 KGQDRAIMRTLSGLSSLVTLSTGSGKSLCYQLPAYLYSRKVGAITLVISPLVSLMEDQVTGVPHF 937
            ..|..||...|.|....:.:.||.||||||||||.:..    .:|:|||||.||:.|||..:...
Human   670 TNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSP----GVTVVISPLRSLIVDQVQKLTSL 730

  Fly   938 -LRAHCLHTNQTAPQRMKIQQMIANGE--IDILLVSPEAVVAGERATGFGAILRQLPPIAFACID 999
             :.|..|..::|..:...|...::..:  |.:|.|:||.:.|..|.......|.:...:|...||
Human   731 DIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVID 795

  Fly  1000 EAHCVSQWSHNFRPSYLMICKVLRKNLGVRTVLGLTATATLPTRVSIINHLGISDGERGIISDIP 1064
            ||||||||.|:||..|..: .:||:......|:.|||||....:..|:..|.|...:  :.|...
Human   796 EAHCVSQWGHDFRQDYKRM-NMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQ--VFSMSF 857

  Fly  1065 LPDNLVLSVSKDENRDAALLQLLNSERFEPCQSIIIYCTRRDECERIAGFIRTCVQDRREPTQDQ 1129
            ...||...|...:.:..|...|....:..|..|.||||..|.||:.:|..:
Human   858 NRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRECDTMADTL-------------- 908

  Fly  1130 TKKRKRVNWQAEPYHAGMPASRRRTVQKAFMSNE-LRIVVATIAFGMGINKPDIRAVIHYNMPRN 1193
                :|....|..||||:..|.|..||:.:::.: .:::.|||||||||:|||:|.|||.::|::
Human   909 ----QRDGLAALAYHAGLSDSARDEVQQKWINQDGCQVICATIAFGMGIDKPDVRFVIHASLPKS 969

  Fly  1194 FESYVQEIGRAGRDGLPSHCHLFLDAKGGDQSELRRHVYSNSIDRHVIRK 1243
            .|.|.||.|||||||..|||.||....  |.:.|:|.:.......|..|:
Human   970 VEGYYQESGRAGRDGEISHCLLFYTYH--DVTRLKRLIMMEKDGNHHTRE 1017

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.