Protein Alignment RecQ4 and blm

DIOPT Version :10

• Sequence 1: NP_652607.1
• Gene: RecQ4 / 53438
• FlyBaseID: FBgn0040290
• Length: 1579
• Species: Drosophila melanogaster
• Sequence 2: XP_017207538.1
• Gene: blm / 572540
• ZFINID: ZDB-GENE-070702-5
• Length: 1450
• Species: Danio rerio
• Alignment Length: 1396
• Identity: 315/1396 - (22%)
• Similarity: 519/1396 - (37%)
• Gaps: 378/1396 - (27%)

  Fly   201 LKPSLSAKLF--QSSRGFAK-RNPRKPLSRCVSSSSSTTSLS-SVPTDHHEELLDFETILIRKAQ 261
            |||......|  :||.|.:| ..|:|     |:.||...:.| ::|:       :||
Zfish    38 LKPKPGGFCFKKKSSSGISKVEVPQK-----VTGSSVLANRSVNIPS-------NFE-------- 82

  Fly   262 EYKEKQQAIANNPMLASEHSKESIKTLVDDGWLRRNTKENTLDEEV-PFAEANNNSGTSKKTNFG 325
                    :..||:..|: ..|.:...|:........|.||::... |||
Zfish    83 --------VTKNPVTFSQ-KPERVAPKVNFFTAPSKPKTNTVNPLANPFA--------------- 123

  Fly   326 LANLDLSKLKPTVKEEKVLQAKPDQMAIIQ--------ELQTDMNS-SMNQKPDHLNHTPPASSQ 381
                    |..|...:..::|.|...|:.:        ||:.|::. |.|:..|..:...|..|:
Zfish   124 --------LNKTPLVQSTIKALPKSAALPKDSTNDQTVELKHDISQLSFNEWDDLDDFETPVKSR 180

  Fly   382 --KSVA--PKNKPPPSEQETDSDSDSVVAESEEEQEPQEYRQLSKRRKIVSTASG-KVEVA--AP 439
              ..||  ...||..|:|.|.|...|...|::..:|.|....::..:.::|.|:| ..|.|  .|
Zfish   181 VASPVAGTSTKKPSVSDQNTSSSCSSKCEETKVNEESQATETITAPKDVLSAANGVSTETAEREP 245

  Fly   440 VEIPNKVEPETETFAQENPDFSADEDQDATYV--PENKKKDKAKRKQAAGKQKTTKPKA------ 496
            .:.|.|.....:...|.....|..||::..:.  |:..:|: .|....|.|.|..:|..
Zfish   246 EDSPIKKSKRPKKSVQHTALLSDTEDEEIIHCVSPDTNQKN-FKSVAVAEKDKWGEPNVIDSDDC 309

  Fly   497 -------------EPKPKTEK-------KAKVKAEKKPKAEKKPRNSKKAIAVEPAPDPEEDERQ 541
                         .|.|..|:       |.|..:|....|.|| .:|:.|..:   |.|.:...:
Zfish   310 EENNHYEGFEDFIPPSPIPEEISLSVSDKEKSSSEPVTPANKK-ESSRSASGL---PAPLDQSAK 370

  Fly   542 PLNPED------LKYVLALEAGDITSVPRINVQDLE-EADATAQRYIRTFAAGPNPGLSEGSNIR 599
            .|...|      ::.:..|    :.::|...:..|. ..:...||..|...      |::|.:.|
Zfish   371 GLKGADDALFSVMESICCL----VDTIPEHELIALTCGTELLLQRAHRKRI------LAKGGSSR 425

  Fly   600 VDEKRAAARKKLEERIAAGKLNENFVTINIQKKKFVRGKKSVNFSKYKKQQWRHKKRVAALSGPD 664
            .....:.:......|...|....|..::.    ....||:     :..|..:..:|.:|::
Zfish   426 TSHSDSVSTPGFLNRPTFGVTPSNLTSLT----PVTSGKR-----EGVKTGFSFRKSIASV---- 477

  Fly   665 MDMGGCDGGVLTCFQC--GGVGHFAQQCKVKGDSLLPLSAQLEEDPSPFPTLAEAQEMASQGAVV 727
            |.:|  |..|.....|  .||       :..|.:..|.|:          |...|......|::.
Zfish   478 MSVG--DESVFEDSDCIINGV-------ETPGGTWNPNSS----------TKISAGRDTFNGSIQ 523

  Fly   728 AHSRNISRLPQAANAAILQGDELNESEEDDQESSGDEEVQQHPDPNWSSDEMDVDFEALDAAVEA 792
            ..|:     |::...........|||             ....|..:|...:|......|::||.
Zfish   524 TLSK-----PESKTDKCYSRLSFNES-------------SNQTDLFYSPKRVDSGSRNADSSVEI 570

  Fly   793 SLSQPVSQEKAASPIKTYV----------GHKIPEEFLKQAGLDTTASSSNRS-------QHGG- 839
            :::...|....|.|:..::          .:.||:.:.:.   .:...|.|.|       |.||
Zfish   571 NIAGSSSLRTGAEPVDDFLLDDFDIDDFDENDIPDYYEEP---PSVLESRNNSGVKTPSVQEGGS 632

  Fly   840 ---------------------VKPLYDLLPDGSVQDT--------TPEVLEALH-MFGHTNFRKG 874
                                 .:|||    .....|.        :||:::..| .||...||..
Zfish   633 SKSFERKTFTPPAPKSIKTPNPEPLY----RNPAHDRFRGFNFPHSPEMMKIFHKKFGLHQFRFN 693

  Fly   875 QDRAIMRTLSGLSSLVTLSTGSGKSLCYQLPAYLYSRKVGAITLVISPLVSLMEDQVTGVPHF-L 938
            |..||..:|.|..:.|.:.||.||||||||||.:.:    .:|:|||||.||:.|||..:... :
Zfish   694 QLEAINASLLGEDTFVLMPTGGGKSLCYQLPACVSA----GVTVVISPLRSLIVDQVQKLTTLDI 754

  Fly   939 RAHCLHTNQTAPQRMKIQQMIANGE--IDILLVSPEAVVAGERATGFGAILRQLPPIAFACIDEA 1001
            .|..|..::...:..:|...::..:  |.:|..:||.|.|..|.......|.:...:|...||||
Zfish   755 CATSLSGDKKDSEAARIYMQLSRKDPAIKLLYATPEKVCASGRMISALQNLYERGLLARLVIDEA 819

  Fly  1002 HCVSQWSHNFRPSYLMICKVLRKNLGVRTVLGLTATATLPTRVSIINHLGISDGERGIISDIPLP 1066
            ||||||.|:|||.|..:.: ||:......::.||||||...:..|:|.|.::..:  :.:.....
Zfish   820 HCVSQWGHDFRPDYKRLHE-LRRMFPNVPIMALTATATPRVQKDILNQLAMTRPQ--VFTMSFNR 881

  Fly  1067 DNLVLSV--SKDENRDAALLQLLNSERFEPCQSIIIYCTRRDECERIAGFIRTCVQDRREPTQDQ 1129
            :||..||  .|.:..|...:|.:  :::.|..|.|:||..|::|:.:|..:
Zfish   882 NNLKYSVLPKKPKKVDEECIQWI--KKYYPRDSGIVYCLSRNDCDTLADSL-------------- 930

  Fly  1130 TKKRKRVNWQAEPYHAGMPASRRRTVQKAFMSNE-LRIVVATIAFGMGINKPDIRAVIHYNMPRN 1193
                :|....|..||||:..|.|..||..:::.: .:::.|||||||||:|||:|.|||.::|::
Zfish   931 ----QRAGIAALAYHAGLSDSDREYVQNKWINQDGCQVMCATIAFGMGIDKPDVRYVIHASLPKS 991

  Fly  1194 FESYVQEIGRAGRDGLPSHCHLF--------------LDAKGGDQS------------------- 1225
            .|.|.||.|||||||..|||.||              :|..|..||
Zfish   992 VEGYYQESGRAGRDGEISHCVLFYSYSDVIRIKRLIAMDKDGNQQSKATHINNLHSMVHFCENVA 1056

  Fly  1226 ELRR---------HVYSNSI-------------------DRHV---IRKLLQKIFVPCSCDK--- 1256
            |.||         |.::.|.                   .|:|   ::|:.:  ||..:|:|
Zfish  1057 ECRRIQLLAYFGEHTFNTSFCKEHPEVICDNCARPNKYKSRNVTDDVKKIAR--FVQDNCEKVGN 1119

  Fly  1257 ---EASKRTALPIPLEGDGPRVHMCPGHE----------IGFSVEK-------------TVEMLD 1295
               :::::..|.:.:     .|.:..|.:          :|.:..|             .|.|.|
Zfish  1120 RYGKSAQQNRLTLNM-----LVEIFLGSKSARIQTGMFGVGAAYSKHNAERLFKKLVLDNVLMED 1179

  Fly  1296 IPAENISTLLCYMELDPRWCISVLSSAYVMAKVISYGGPKYLKHAAKECPPLAMAIALQIRDKTF 1360
            :...|....:.|:...|: .:|||:....:....:.......||.|..|            :|..
Zfish  1180 LYITNSGQAVAYISAGPK-AMSVLNGCMQVEFHETESASSIRKHRASVC------------EKVS 1231

  Fly  1361 KEDSNIIEF--SVTDIAAGIGWNSGVVKYQL 1389
            |.:..:.:.  .:.|:...:|...|:..|.:
Zfish  1232 KREEMVKKCLGELNDLCKKLGKVFGIHYYNI 1262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RecQ4	NP_652607.1	RecQL4_SLD2_NTD	9..55	CDD:412085
		RecQ	855..>1216	CDD:440280	130/375 (35%)
blm	XP_017207538.1	BLM_N	12..346	CDD:465064	78/360 (22%)
		BDHCT	379..419	CDD:462356	6/49 (12%)
		recQ_fam	679..1164	CDD:129701	151/518 (29%)
		HRDC	1235..1314	CDD:128635	4/28 (14%)