Protein Alignment RecQ4 and recql4

DIOPT Version :10

• Sequence 1: NP_652607.1
• Gene: RecQ4 / 53438
• FlyBaseID: FBgn0040290
• Length: 1579
• Species: Drosophila melanogaster
• Sequence 2: XP_001920631.5
• Gene: recql4 / 567383
• ZFINID: ZDB-GENE-091112-2
• Length: 1459
• Species: Danio rerio
• Alignment Length: 1703
• Identity: 547/1703 - (32%)
• Similarity: 789/1703 - (46%)
• Gaps: 379/1703 - (22%)

  Fly     9 KYQKYKLRVKVWEKDFKKKNGRVPSKYDIRDASQEIRDSYKMYYKLKTSFLEETLNDVLSEDGYD 73
            :|...|:.:|.||:.|.:.|.|.|:|.||..|.:|.|..||.|..||.:   :..||.:.|....
Zfish     3 RYNDVKILLKKWEQSFFQTNNRKPNKDDIDKAPEETRQLYKEYRSLKVA---KERNDAVKESQTK 64

  Fly    74 ILEMSQASDFGVSMLDQDVSLNEGPQLPLDISALVGPQSSGNLEEIPQSVEGSFSNLIDLPNRQV 138
            ..| ||:|..|.......::..   .||:.:..|    ||.:.|.:..|.:        ....::
Zfish    65 PPE-SQSSTDGSGCWGSHLNRK---NLPVALPKL----SSDDKETLKASAQ--------YFGMKL 113

  Fly   139 LTNL--VNRDENHVIRKFEAVEELP-------INQNAWGLNVSKKPPAP----PQPVEASKSAPG 190
            ..||  :.::.:..::|.......|       ::.||...:|....|.|    |.|
Zfish   114 KNNLGGLTKERSFSLKKAATPRRTPQKLIKDTVDSNAAATDVESHTPKPANTCPDP--------- 169

  Fly   191 HGKQPKAGASLKPSLSAKL-FQS--SRGFAKRNPRKPLSRCVSSS------------SSTTSLSS 240
                     |..|..:||: |:.  |..|....|.||.|..|.|:            |.|...||
Zfish   170 ---------SAAPVQAAKMDFEDDPSDPFPSITPSKPCSTVVGSAQKSVERVQFLRQSITRRFSS 225

  Fly   241 VPTDHHEELLDFETILIRKAQEYKEKQQAIANNPMLASEHSKESIKTLVDDGWLRRNTKENTLDE 305
            |.:........|:        |.:|.|:.:|.|..||.:.     |:.:......::....|..|
Zfish   226 VDSGWLARCQVFD--------EVEEPQKPVAGNSELAKDE-----KSFLQPAVGSKSGSPGTHGE 277

  Fly   306 EVPFAEANNNSGTSKKTNFGLANLDLSKLKPTVKEEKVLQAKPDQMAIIQELQTDMNSSMNQKPD 370
            .|....:.|...|       .:|..|.:.|.::.||              |.|.|:.:|..:...
Zfish   278 RVSHKNSPNEGQT-------FSNTLLGRKKSSLPEE--------------EAQIDLVTSSVRNNV 321

  Fly   371 HLN--HTPPASSQKSVAPKNKPPPSEQETDSDSDSVVAESEEEQEPQEYRQLSKRRKIVSTASGK 433
            .||  ...|.:..:.|:.|:.|            .:..:.|...|..|:...:|:||   |.:.|
Zfish   322 VLNAISGSPGTHGERVSLKSSP------------KLRVDDENLSEEPEFTPNTKQRK---TKARK 371

  Fly   434 VEVAAPVEIPNKVEPETETFAQENPDFSADEDQDATYVPENKKKDKAKRKQAAGKQKTTKPKAEP 498
            .:.:.......|.:.|    |....|....|:::...    ||:.|.|:.:.||:.       :|
Zfish   372 DQDSGAKTKGRKRQRE----ADNGDDMDESEEKEGGV----KKRRKTKKGETAGED-------QP 421

  Fly   499 KPKTEKKAKVKAEKKPKAEKKPRNSKKAIAVEPAPDPEEDERQPLNPEDLKYVLALEAGDITSVP 563
            |.:.:||.||:.:....:.:..:..|:|:       |:|:                ..|::
Zfish   422 KKRGKKKGKVEEDDDDGSSENKKPQKRAM-------PQEN----------------LLGEV---- 459

  Fly   564 RINVQDLEEADATAQRYIRTFAAGPNPGLSEGSNIRVDEKRAAARKKLEERIAAGKLNENFVTIN 628
                 |.|||.|.|.....|....|... ::|                           |||.||
Zfish   460 -----DEEEARAAAYAMKNTVRVRPTKN-TDG---------------------------NFVKIN 491

  Fly   629 IQKKKFVRGKKSVNFSKYKKQQWRHKKRVAALSGPDMDMG-----GCDGGVL----TCFQCGGVG 684
            ::||..|:| .::..:..:||.:..|.:   |.|.....|     |..||..    ||::|||.|
Zfish   492 LKKKSHVKG-FALRGAALRKQMYMQKFQ---LKGERFGGGFGRGRGRFGGFNRQGDTCYKCGGTG 552

  Fly   685 HFAQQCKVKGDSLLPLSAQLEEDPSP-------FPTLAEAQEMASQGAVVAHSRNISRLPQAANA 742
            |:||.|:.|    :|::...|:..:|       .|||.|    .::......|..|...|.|
Zfish   553 HWAQDCRGK----VPVNTSAEQQETPVEEEEFELPTLEE----VARATGTLRSEPIVAPPSA--- 606

  Fly   743 AILQGDELNESEEDDQESSGDEEVQQHPDPNWSSDEMDVDFEALDAAVEASLSQPVSQEKAASPI 807
               .||   .||:::|                            .|.:..::.:|..:..|..|
Zfish   607 ---DGD---SSEKEEQ----------------------------GAEILLNIIRPDYERPAPPP- 636

  Fly   808 KTYVGHKIPEEFLKQAGLDTTASSSNRSQHGGVKPLYDLLPDGSVQDTTPEVLEALHMFGHTNFR 872
                    |.|                       |||.|..||.|||..|||.|||..||:.:||
Zfish   637 --------PME-----------------------PLYKLKDDGKVQDVPPEVYEALRDFGYKSFR 670

  Fly   873 KGQDRAIMRTLSGLSSLVTLSTGSGKSLCYQLPAYLYSRKVGAITLVISPLVSLMEDQVTGVPHF 937
            .||:.||||.|||||:||.||||.|||||||||||||:::..:||||:|||||||:||::|:|..
Zfish   671 PGQEAAIMRILSGLSTLVVLSTGMGKSLCYQLPAYLYAQRSKSITLVVSPLVSLMDDQLSGLPPK 735

  Fly   938 LRAHCLHTNQTAPQRMKIQQMIANGEIDILLVSPEAVVAGERATGFGAI--LRQLPPIAFACIDE 1000
            |:|.|:|:|.:|.||....:.:..|::.:||:||||:|.|.. :|.|.:  ..||||:|||||||
Zfish   736 LKAACIHSNMSAKQREAAIEKVKAGQVHVLLLSPEALVGGGH-SGSGCLPPADQLPPVAFACIDE 799

  Fly  1001 AHCVSQWSHNFRPSYLMICKVLRKNLGVRTVLGLTATATLPTRVSIINHLGISDGERGIISDIPL 1065
            |||||:|||||||.||.:|||||..||||.:|||||||||.|.:.|..||.|||.:...:....:
Zfish   800 AHCVSEWSHNFRPCYLRLCKVLRDRLGVRCLLGLTATATLSTALDIARHLDISDEDGIAVRSAAV 864

  Fly  1066 PDNLVLSVSKDENRDAALLQLLNSERFEPCQSIIIYCTRRDECERIAGFIRTCVQ---------- 1120
            |.||.||||.|.::|.||:.||..|||....|:|:|||||:|..|||..:|||:|
Zfish   865 PHNLQLSVSMDRDKDQALVSLLKGERFGALDSVIVYCTRREETSRIAALLRTCLQGVMLRESSKH 929

  Fly  1121 -----------DRREPTQDQTKKRKRVNWQAEPYHAGMPASRRRTVQKAFMSNELRIVVATIAFG 1174
                       .:::....:.|.||.:.|.||.||||:.||.||.||..||..|||:||||:|||
Zfish   930 TALQEDDDNPVGKKKKALARKKIRKPLKWIAEAYHAGLSASERRRVQNNFMCGELRVVVATVAFG 994

  Fly  1175 MGINKPDIRAVIHYNMPRNFESYVQEIGRAGRDGLPSHCHLFLDAKGGDQSELRRHVYSNSIDRH 1239
            ||::|.|:|.:||||||::|||||||||||||||.|:|||||||.:|||..|||||:|::::|.:
Zfish   995 MGLDKSDVRGIIHYNMPKSFESYVQEIGRAGRDGHPAHCHLFLDPEGGDLHELRRHIYADTVDYY 1059

  Fly  1240 VIRKLLQKIFVPCSCDK------------EASKRTALPIPLEGDG---------------PRVH- 1276
            .::||:||:|.||.|.:            |.|....|.:.|..|.               |:.|
Zfish  1060 TVKKLVQKVFPPCKCRQIQQKQQDLAQAAEVSDSELLEMELCDDSDPHQNEIPTLTHQQTPQTHT 1124

  Fly  1277 -----------------MCPGHEIGFSVEKTVEMLDIPAENISTLLCYMELDPRWCISVLSSAYV 1324
                             .|..||....:::|||.|||..|::.|||||:||.|:..:.:|.....
Zfish  1125 PEETEERPQLSDECVQRFCHTHERAIPMQETVEALDITEESLETLLCYLELHPQQWVELLHPTLS 1189

  Fly  1325 MAKVISYGGPKYLKHAAKECPPLAMAIALQIRDKTFKEDSNIIEFSVTDIAAGIGWNSGVVKYQL 1389
            :.|:..||||:.|:..||.|.|:|:.:|.:.......:..:.:||.|.::|..:||...:||..|
Zfish  1190 VCKLQCYGGPQQLRKIAKLCAPVAVVLARRRMAGERVQSCDALEFDVVELADTMGWQLPLVKRGL 1254

  Fly  1390 KDLEWVKVNGY---PKRSPITVSFYDLGFRIKVPGDFTESEIDNALDTLYTRSVKQERTQLIQLQ 1451
            :.|:|....|.   ..||.:.|.|..|.|..:..||.|..|:|.....|:.|...||.|||.||:
Zfish  1255 RQLQWGSDTGSYGGTGRSGVHVEFSALSFYFRSYGDLTADELDAVCAFLHGRVKTQENTQLYQLK 1319

  Fly  1452 YVAHGLAAVAYSSCGQCCNADFPQDRGEQLKAIVRNYFANDYPQDLELE---IEPSNVPDE---- 1509
            .......:|||.:|..|.: |..:.|.:.||.::.:||  |..::|||.   :|..:..:|
Zfish  1320 TCFRAFRSVAYRNCSLCLD-DLEESRSQALKDLLSDYF--DKRRNLELSKQCLEDEHDEEEELNK 1381

  Fly  1510 --------NIIDDVHALINMYPDNTFTGRNIARIFHGIMSPNYPAVIWGR-CKFWRAHVKVDFNR 1565
                    .|..|:.|.:....|..|:||.:|||||||.||.|||.::|| .:|||.:::.|||.
Zfish  1382 CKMRDWETQICADIRAFLCSRSDEKFSGRAVARIFHGIGSPCYPAQVYGRDRRFWRKYIQFDFNE 1446

  Fly  1566 ILHLANMAIIKRR 1578
            |:.||...||:.|
Zfish  1447 IIRLATQEIIRTR 1459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RecQ4	NP_652607.1	RecQL4_SLD2_NTD	9..55	CDD:412085	18/45 (40%)
		RecQ	855..>1216	CDD:440280	213/383 (56%)
recql4	XP_001920631.5	RecQL4_SLD2_NTD	2..49	CDD:412085	18/45 (40%)
		Drc1-Sld2	5..>186	CDD:371692	50/217 (23%)
		PLN02967	289..>460	CDD:215521	46/253 (18%)
		ZnF_C2HC	544..559	CDD:197667	9/14 (64%)
		RecQ	655..>1058	CDD:440280	226/403 (56%)