DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ4 and Blm

DIOPT Version :9

Sequence 1:	NP_652607.1	Gene:	RecQ4 / 53438	FlyBaseID:	FBgn0040290	Length:	1579	Species:	Drosophila melanogaster
Sequence 2:	NP_524319.2	Gene:	Blm / 41366	FlyBaseID:	FBgn0002906	Length:	1487	Species:	Drosophila melanogaster

Alignment Length:	1681	Identity:	344/1681 - (20%)
Similarity:	555/1681 - (33%)	Gaps:	616/1681 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DDSVFKLKYQKY---------KLRVKVWEKDFKKKNGRVPSKYDIRD-------ASQEIRDSYKM 50
            |....|||...|         ||..|.:.:|..||    |:..|:..       |.:..|||.|.
  Fly    77 DPRTAKLKKHTYLDLSVSPLAKLSAKKYARDSPKK----PTSLDLSVSPLAELLAKKSDRDSPKK 137

  Fly    51 YYKLKTSFLEETLND--VLSEDGYDILEMSQASDFGVSMLDQDVSLNEGPQLPL---DISALVGP 110
            ..:.:.|:....|::  |.::...|.|......:...|:    |.|::.|:..:   :...|..|
  Fly   138 PVQNENSYTYRGLSESPVENKSIGDTLRKPPQKERKTSI----VWLSDSPEKKVTQNERKILDSP 198

  Fly   111 QSSGNLEEIPQSVEGSFSNLIDLPNRQVLTNLVNRDENHVIRKFEAVEELPINQNAWGLNVSKKP 175
            ....:.|:.|....|:..:|:.||:                                       .
  Fly   199 LQRFSFEDFPNKENGNRHHLLTLPD---------------------------------------S 224

  Fly   176 PAPPQPVE--------------ASKSAPGHGKQPKAGASLKPSL------------SAKLFQSS- 213
            |.|||||:              ..|.:|.:.......||:...|            |..||:.|
  Fly   225 PPPPQPVKKPEKTMWQNETKTIQDKDSPANPLVSNNLASISTLLDSSRAPNTYKGSSRNLFEDSP 289

  Fly   214 -----------RGFAKRN--PRKPLSRCVSSSSSTTSLSSVPTDHHEELLDFETILIRKAQEYKE 265
                       .|.||.|  |.||.:..:..:|.|:|.|..........:.|:..|   |...|:
  Fly   290 EKSGSGEQGYKLGSAKENEIPTKPATASLERNSVTSSPSPAAPLKPRYSVAFDNSL---ADYLKD 351

  Fly   266 KQQAIANNPMLASEHSKESIKTLVDDGWLRRNT------KENTLDEEVPFAEANNNSGTSK---- 320
                :|.|...:.:.:|::.:||.......|||      |..:|.:::|....|..:|...
  Fly   352 ----LAQNDNFSIDPNKQNTETLKSTLGFFRNTYVELMEKYCSLIDQIPAMHFNEIAGFQPNTFL 412

  Fly   321 ---------KTNFGLANLDLSKLKPTVK-EEKVLQAKPDQMAIIQELQTDMNSSMNQKPDHLNHT 375
                     |....|....|.|.:..:| |::.|:.:..:|...|..||.::||..:|...:...
  Fly   413 KLKVMRQKFKARTQLVQNSLDKKESQLKAEQEALEKEEIEMQAEQAQQTVLSSSSPEKSRPIMPL 477

  Fly   376 PPASSQKSV--------------APKNKPPPSEQETDSDSDSVVAESEEEQEPQEYRQLSKRRKI 426
            |.....|..              .|.|..|||                   .|::.:.:.||:::
  Fly   478 PKVQEIKDEKIPNRNQLIHDLCGEPDNFSPPS-------------------SPRDTQLIPKRQQL 523

  Fly   427 VSTASGKVEVAAPVEIPNKVEPETETFAQENPDFSADEDQDATYVPENKKKDKAKRKQAAGKQKT 491
            ::...|              ||:         |||          |.:|:.|
  Fly   524 INDLCG--------------EPD---------DFS----------PPSKQND------------- 542

  Fly   492 TKPKAEPKPKTEKKAKVKAEKKPKAEKKPRNSKKAIAVEPAPDPEEDERQPLNPEDLKYVLALEA 556
                                        |...:|.                   |:|.:.|..|.
  Fly   543 ----------------------------PHLLRKC-------------------EELVHDLCEEP 560

  Fly   557 GDITSVPRINVQDLEEADATAQRYIRTFAAGPNPGLSEGSNIRVDEKRAAARKKLEERIAAGKLN 621
            .|..:...:...||||....          ||..|.:...   :|:         :|....|.|.
  Fly   561 DDYLAQSMMLDGDLEEEQLN----------GPTQGTTTSG---MDD---------DEDDLEGLLA 603

  Fly   622 ENFVTINIQKKKFVRGKKSVNFSKYK-----KQQWRHKKRVAALSGPDMDMGGCDGGVLTCFQCG 681
            |    |..:.:|....:...|...||     |.:.:||:
  Fly   604 E----IEDEHQKMQGRRSEFNGYSYKELEAVKVKEKHKE-------------------------- 638

  Fly   682 GVGHFAQQCKVKGDSLLPLSAQLEEDPSPFPTLAEA--QEMASQGAVVAHSRNISRLPQAANAAI 744
                            .|::..|::|  .||...||  ::|.||.|  |:...:|....:.:.::
  Fly   639 ----------------TPINISLDDD--GFPEYDEAMFEQMHSQAA--ANKSRVSSAGPSTSKSV 683

  Fly   745 LQGDELNESEEDDQESSGDEEVQQHPDPNWSSDEMDVDFEALDAAVEASLSQPVSQEKAASPIKT 809
            :...:  .|....|:.||:.....|      :|.:..:|:
  Fly   684 VPTKQ--TSALHSQKLSGNFHANVH------NDGITGEFD------------------------- 715

  Fly   810 YVGHKIPEEFLKQAGLDTTASSSNRSQHGGVKPLYDLLPDGSVQDTTPEVLEALHMFGHTNFRKG 874
              |.|.              ..|.|..||                       ..:.||..:||..
  Fly   716 --GQKF--------------EHSTRLMHG-----------------------LSYSFGLKSFRPN 741

  Fly   875 QDRAIMRTLSGLSSLVTLSTGSGKSLCYQLPAYLYSRKVGAITLVISPLVSLMEDQVTGVPHF-L 938
            |.:.|..||.|....|.:.||.||||||||||.|    ...:|:|||||.||:.||:..:... :
  Fly   742 QLQVINATLLGNDCFVLMPTGGGKSLCYQLPAIL----TEGVTIVISPLKSLIFDQINKLASLDI 802

  Fly   939 RAHCLHTNQTAPQRMKIQQMIANGE--IDILLVSPEAVVAGERATGFGAILRQLPPIAFACIDEA 1001
            .|..|...|.....|.|.:.:.:..  :.:|.|:||.:.:..|.......|.....|:...||||
  Fly   803 CAKSLSGEQKMADVMAIYRDLESQPPMVKLLYVTPEKISSSARFQDTLDTLNSNNYISRFVIDEA 867

  Fly  1002 HCVSQWSHNFRPSYLMICKVLRKNLGVRTVLGLTATATLPTRVSIINHLG-------ISDGERGI 1059
            ||||||.|:|||.|..: .||:|.......:.||||||...|:.|:..|.       :|...|..
  Fly   868 HCVSQWGHDFRPDYKKL-GVLKKRFPNVPTIALTATATPRVRLDILAQLNLKNCKWFLSSFNRSN 931

  Fly  1060 ISDIPLPDNLVLSVSKDENRDAALLQLLNSERFEPCQ-SIIIYCTRRDECERIAGFIRTCVQDRR 1123
            :....||...| |...|.:|..         |.:|.. |.||||..|.||:
  Fly   932 LRYRVLPKKGV-STLDDISRYI---------RSKPQHFSGIIYCLSRKECD-------------- 972

  Fly  1124 EPTQDQTKKRKRVNWQAEPYHAGMPASRRRTVQKAFMSNELRIVVATIAFGMGINKPDIRAVIHY 1188
                :.:||..:...:|..||||:..:.|.:.||.:::.::|::.||:||||||:|||:|.|:||
  Fly   973 ----ETSKKMCKDGVRAVSYHAGLTDTDRESRQKDWLTGKMRVICATVAFGMGIDKPDVRFVLHY 1033

  Fly  1189 NMPRNFESYVQEIGRAGRDGLPSHCHLFLDAKGGDQSELRRHVYSNSIDRHVIRKL-LQKIF-VP 1251
            ::|::.|.|.||.|||||||..:.|.|:.:.  .|...:::.:.|:...::.::|: :..:: :.
  Fly  1034 SLPKSIEGYYQEAGRAGRDGDVADCILYYNY--SDMLRIKKMLDSDKALQYNVKKIHVDNLYRIV 1096

  Fly  1252 CSCDKEASKRTALPIPLEGDGPRVHMCPGHEIGFSVEKTVEMLDIPAENISTLLCYMELDPRWCI 1316
            ..|:.....|.|..:...|:         |   |:.|:.:|..:...:|......|..:|.
  Fly  1097 GYCENLTDCRRAQQLDYFGE---------H---FTSEQCLENRETACDNCINKRAYKAVDA---- 1145

  Fly  1317 SVLSSAYVMAKVISYGGPKYLKHAAKECPPLAMAIALQIRDKTFKEDSNIIEFSVTDIAAGIGWN 1381
                                |:||.|        .|..::|..    |....|::..||
  Fly  1146 --------------------LEHARK--------AARAVKDLC----SGRSRFTLLHIA------ 1172

  Fly  1382 SGVVKYQLKDLEWVKVNGYPKRSPITVSFYDLGFRIKVPGDFTESEIDNALDTLYTRSVKQERTQ 1446
             .|:|                           |.:||...||...:..:
  Fly  1173 -DVLK---------------------------GSKIKKIIDFNHHKTPH---------------- 1193

  Fly  1447 LIQLQYVAHGLAAVAYSSCGQCCNADFPQDRGEQL--KAIVRNY------FANDYPQDLELEIEP 1503
                    ||:.            .|:.::...:|  |.::..:      |.||:||..
  Fly  1194 --------HGVL------------KDWDKNDVHRLLRKMVIDGFLREDLIFTNDFPQAY------ 1232

  Fly  1504 SNVPDENIIDDVHALINMYPDNTFTGRNIARIFHGIMSPNYPAVIWGRCKFWRAHV 1559
                                  .:.|.||:::..|  :||:...:....|..:|.|
  Fly  1233 ----------------------LYLGNNISKLMEG--TPNFEFAVTKNAKEAKAAV 1264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ4	NP_652607.1	RecQL4_SLD2_NTD	9..55	CDD:421279	15/61 (25%)
RecQ4	NP_652607.1	RecQ	864..>1218	CDD:223588	130/364 (36%)
Blm	NP_524319.2	RQC	1140..1253	CDD:286470	35/248 (14%)
		HRDC	1286..1352	CDD:278967
		RecQ	729..1359	CDD:223588	180/719 (25%)
		DEAD	739..908	CDD:278688	66/173 (38%)
		HELICc	931..1061	CDD:238034	55/157 (35%)
		RecQ_Zn_bind	1066..1134	CDD:292742	11/79 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457824
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13710
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850