DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ4 and Recql4

DIOPT Version :9

Sequence 1:	NP_652607.1	Gene:	RecQ4 / 53438	FlyBaseID:	FBgn0040290	Length:	1579	Species:	Drosophila melanogaster
Sequence 2:	XP_008763788.1	Gene:	Recql4 / 300057	RGDID:	1307732	Length:	1223	Species:	Rattus norvegicus

Alignment Length:	1637	Identity:	468/1637 - (28%)
Similarity:	691/1637 - (42%)	Gaps:	496/1637 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KLRVKVWEKDFKKKNGRVPSKYDIRDASQEIRDSYKMYYKLKTSFLEETLNDVLSEDGYDILEMS 78
            :.|::.||:.|.:.:||.|:|.|:..|.:|.|..|:.|..||.:..:       ::||:.:.:.|
  Rat     8 RARLQDWERAFVRLHGRRPAKEDVEAAPEETRALYREYRNLKQAVSQ-------ADDGHRVQKQS 65

  Fly    79 QASDFGVSMLDQDVSLNEGPQLPLDISALVGPQSSGNLEEIPQSVEGSFSNLIDLPNRQVLTNLV 143
            .|            ...|..|.|....:.:...::.|.:.||:  :...|::.|. .:::..||.
  Rat    66 LA------------KAAEEEQEPSCWGSHLNRAATQNTQSIPK--QSPLSSIQDY-GKRLKANLK 115

  Fly   144 N---------RDENHVIRKFEAVEELPINQNAWGLNVSKKPPAP----PQPVEASKSAPG-HGKQ 194
            |         |...|..|....|.             :.:||.|    |.|.:|:.:.|. ...|
  Rat   116 NTLQGGPTLSRKLQHQKRSLSIVP-------------TSRPPGPRTESPCPEQANDALPQVPVPQ 167

  Fly   195 PKAG--ASLKPSLSAKLFQSSRGFAKRNPRKPLSRCVSSSSSTTSLSSVPTDHHEELLDFETILI 257
            |:.|  ..|:.|||.:|
  Rat   168 PRQGQLQKLQSSLSLRL------------------------------------------------ 184

  Fly   258 RKAQEYKEKQQAIANNPMLASEHSKESIKTLVDDGWLRRNTKENTLDEEVPFAEANNNSGTSKKT 322
                                         :.:|.|||.|.....:...|||
  Rat   185 -----------------------------SSLDPGWLERCQNRVSDPLEVP-------------- 206

  Fly   323 NFGLANLDLSKLKPTVKEEKVLQAKPDQMAIIQELQTDMNSSMNQKPDHLNHTPPASSQKSVAPK 387
              |...|||
  Rat   207 --GACGLDL-------------------------------------------------------- 213

  Fly   388 NKPPPSEQETDSDSDSVVAESEEEQEPQEYRQLSKRRKIVSTASGKVEVAAPVEIPNKVEPETET 452
                                |.:|.:||              .||||.|.:| :|.::|..::..
  Rat   214 --------------------SAKESQPQ--------------MSGKVNVISP-DILSEVSSQSPQ 243

  Fly   453 FAQENPDFSADEDQDATYVPENKKKDKAKRKQAAGKQKTTKPKAEPKPKTEKKAKVKAEKKPKAE 517
            ...:.|      .|..:.:|::......|||:                  .:|.:..|:.:|.::
  Rat   244 ALAQQP------AQVLSQIPKSSNSKDRKRKR------------------NEKGEDFAQAQPSSQ 284

  Fly   518 KKPRNSKKAIAVEPAPDPEEDERQPLNPEDLKYVLALEAGDITSVPRINVQDLEEADATAQRYIR 582
            ..|.:                                                |.|.|||.
  Rat   285 AGPLS------------------------------------------------EGAGATAH---- 297

  Fly   583 TFAAGPNPGLSEGSNIRVDEKRAAARK-KLEERIAAGKL----------NENFVTINIQKKKFVR 636
              ..|| ||  |.:.:.|.:.|.::.: :.|...:|..|          ..|:|.:|::.|.|||
  Rat   298 --GQGP-PG--EPTQVTVPQHRCSSNQARTENAKSAAHLPMSPRPASLDRGNYVRLNMKTKCFVR 357

  Fly   637 GKKSVNFSKYK-------KQQWRHKKRVAALSGPDMDMGGCDGGVLTCFQCGGVGHFAQQCKVKG 694
                |..|:.:       ||:|:.|:.....|||...:..      |||:||..||:|.||
  Rat   358 ----VGASRGRLLRKQVWKQKWKKKQEWFGKSGPRATVKD------TCFRCGQFGHWASQC---- 408

  Fly   695 DSLLPLSAQLEEDPSPFPTLA--------EAQEMASQGAVVAHSRNISRLPQAANAAILQGDELN 751
                   :|...:|.|..||.        :...:::.|.|...:...|               .|
  Rat   409 -------SQPALNPGPGSTLTIQPKGDRNDKHPISTLGGVAQKTGTTS---------------CN 451

  Fly   752 ESEEDDQESSGDEEVQQH-PDPNWSSDEMDVDFEALDAAVEASLSQPVSQEKAASPIKTYVGHKI 815
            .|..::.|.:|......| |.|
  Rat   452 HSAGEETEPAGPVLPVPHCPTP------------------------------------------- 473

  Fly   816 PEEFLKQAGLDTTASSSNRSQHGGVKPLYDLLPDGSVQDTTPEVLEALHMFGHTNFRKGQDRAIM 880
                                    |.|||...|.|.|.||..||.:.|...||..||.||:||:|
  Rat   474 ------------------------VLPLYPPGPLGQVADTPAEVFQVLEQLGHHTFRPGQERAVM 514

  Fly   881 RTLSGLSSLVTLSTGSGKSLCYQLPAYLYSRKVGAITLVISPLVSLMEDQVTGVPHFLRAHCLHT 945
            |.|||:|:|:.|.||:||||||||||.||:::...:|||:|||:|||:|||:.:|..|:|.|||:
  Rat   515 RILSGISTLLVLPTGAGKSLCYQLPALLYAKRSPCLTLVVSPLLSLMDDQVSDLPSCLKAACLHS 579

  Fly   946 NQTAPQRMKIQQMIANGEIDILLVSPEAVVAGERATGFGA-------ILRQLPPIAFACIDEAHC 1003
            ..|..||..:.:.:...::.:|:|||||:|      |.||       ...||||:|||||||.||
  Rat   580 GMTKKQRESVLKKVRAAQVHVLIVSPEALV------GCGAKGPANLPPAAQLPPVAFACIDEVHC 638

  Fly  1004 VSQWSHNFRPSYLMICKVLRKNLGVRTVLGLTATATLPTRVSIINHLGISDGERGIISDIPLPDN 1068
            :|||||||||.||.:|||||:::|||..||||||||..|...:..||||:: |..:.....:|.|
  Rat   639 LSQWSHNFRPCYLRVCKVLREHMGVRCFLGLTATATRSTARDVAQHLGIAE-ELEVSGSASIPAN 702

  Fly  1069 LVLSVSKDENRDAALLQLLNSERFEPCQSIIIYCTRRDECERIAGFIRTCVQDRREPTQDQTKKR 1133
            |.||||.|.:.|.||:.||..:||....||||||.||.:.||:|..:|||:...|:     :|.|
  Rat   703 LHLSVSMDRDSDQALVTLLQGDRFRTLDSIIIYCARRKDTERVAALLRTCLSTVRD-----SKPR 762

  Fly  1134 KR-VNWQAEPYHAGMPASRRRTVQKAFMSNELRIVVATIAFGMGINKPDIRAVIHYNMPRNFESY 1197
            .| ....||.|||||.:..|:.||:|||...||:||||:|||||:::||:|||:|..:|.:||||
  Rat   763 GRGPETLAEAYHAGMCSQERKRVQQAFMQGHLRMVVATVAFGMGLDRPDVRAVLHLGLPPSFESY 827

  Fly  1198 VQEIGRAGRDGLPSHCHLFLDAKGGDQSELRRHVYSNSIDRHVIRKLLQKIFVPCSCDKEASKRT 1262
            ||.||||||||.|:||||||..:|.|..||.|||:::|.|...::||:|::|..|||    ::|.
  Rat   828 VQAIGRAGRDGKPAHCHLFLHPQGEDLWELSRHVHADSTDFLAVKKLVQRVFPACSC----AQRP 888

  Fly  1263 ALPIP--LEGDGPRVH-----MCPGHEIGFSVEKTVEMLDIPAENISTLLCYMELDPRWCISVLS 1320
            ..|:.  .|..|.:.:     .|.||:....|:.||..||:..|.|.|||||:||.||..:.:|.
  Rat   889 MSPLEEVKEHSGQQTYPVLGLACRGHKRALPVQSTVLALDMKEEAIETLLCYLELHPRHWLELLP 953

  Fly  1321 SAYVMAKVISYGGPKYLKHAAKECPPLAMAIALQIRDKTFKEDSNIIEFSVTDIAAGIGWNSGVV 1385
            ..|....:...||...|:.....|||||...| :...|...:.|:.:||.|.::|..:||....|
  Rat   954 YTYAHCHLRCPGGSAQLQALVHRCPPLAACWA-KWPPKDTSQGSSALEFDVVELADSMGWELASV 1017

  Fly  1386 KYQLKDLEW--VKVNGYPKRSPITVSFYDLGFRIKVPGDFTESEIDNALDTLYTRSVKQERTQLI 1448
            :..|..|:|  ....|.|:.:.:.|.|.:|.|.:...||.|:.|.|...|.||:|...:|...|.
  Rat  1018 RQALHQLKWDPEPKKGAPQGTGVLVEFSELAFHLHSRGDLTDEEKDQICDFLYSRVQAREHKALA 1082

  Fly  1449 QLQYVAHGLAAVAYSSCGQCCNADFPQDRG--EQLKAIVRNYFANDYPQDLELEIEPSNVP---- 1507
            .|..::....:||:.|||.|..   ..|.|  .::|.:|..||..:..::.|..::.:..|
  Rat  1083 HLHQMSKAFQSVAFPSCGPCLE---QSDEGHSNRVKTLVSYYFEEEEEEEEEETMKDTQDPKPGQ 1144

  Fly  1508 ------DENIIDDVHALINMYPDNTFTGRNIARIFHGIMSPNYPAVIWGR-CKFWRAHVKVDFNR 1565
                  ::.:..|||.|:::.|:..|:||.:|||||||.||.|||.::|: .:|||.::.:||:.
  Rat  1145 TQLQDWEDQVRRDVHQLLSLRPEEKFSGRAVARIFHGIASPCYPAQVFGQDRRFWRKYLHLDFHA 1209

  Fly  1566 ILHLANMAIIKR 1577
            ::|||...::.|
  Rat  1210 LMHLATEELLLR 1221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ4	NP_652607.1	RecQL4_SLD2_NTD	9..55	CDD:421279	14/40 (35%)
RecQ4	NP_652607.1	RecQ	864..>1218	CDD:223588	191/361 (53%)
Recql4	XP_008763788.1	ZnF_C2HC	394..408	CDD:197667	8/13 (62%)
		DEXDc	497..700	CDD:214692	108/209 (52%)
		DEAD	506..679	CDD:278688	99/178 (56%)
		HELICc	714..846	CDD:238034	74/136 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348966
Domainoid	1	1.000	221	1.000	Domainoid score	I2529
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	643	1.000	Inparanoid score	I778
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D367596at33208
OrthoFinder	1	1.000	-	-		FOG0007178
OrthoInspector	1	1.000	-	-		oto95514
orthoMCL	1	0.900	-	-		OOG6_105088
Panther	1	1.100	-	-	LDO	PTHR13710
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5288
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800