DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ4 and Wrn

DIOPT Version :9

Sequence 1:	NP_652607.1	Gene:	RecQ4 / 53438	FlyBaseID:	FBgn0040290	Length:	1579	Species:	Drosophila melanogaster
Sequence 2:	XP_006253318.1	Gene:	Wrn / 290805	RGDID:	1564788	Length:	1400	Species:	Rattus norvegicus

Alignment Length:	1238	Identity:	295/1238 - (23%)
Similarity:	480/1238 - (38%)	Gaps:	336/1238 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 TILIRKAQEYKEKQQAIANNPMLASEHSKESIKTLVDDGWLRRNTKENTLDEEVPFA-------- 310
            |.|.||..|:...|     |...|:: .|.||             :::.|::::||.
  Rat     4 TSLRRKFPEWMSTQ-----NKSCATQ-EKASI-------------QKSVLEDDLPFLEFTGSVVY 49

  Fly   311 --EANNNSGTSKKTNFGLANLDL----SKLKPTVKEEKVLQAKPDQMAIIQELQTDMNSSMNQKP 369
              ||::.|..|:..:..|::.|:    .:..|..|     |.|..::|:||       ..:::..
  Rat    50 SYEASDCSFLSEDISMHLSDGDVVGFDMEWPPIYK-----QGKRSRVAVIQ-------LCVSESK 102

  Fly   370 DHLNHTPPASSQKSVAPKNKPPPSEQETDSDSDSVVAESEEEQEPQEYR-QLSKRRKIVSTASGK 433
            .:|.|.    |..||.|:......|.::...: .|..|.::.:..:::. :|....::...|:.|
  Rat   103 CYLFHI----SSMSVFPQGLKMLLENKSIRKA-GVGIEGDQWKLLRDFDVKLESFVELTDVANRK 162

  Fly   434 VEVAAPVEIPNKVEP-------ETETFAQEN-PDFSADEDQD--------ATYVPENKKKDKAKR 482
            ::.|....:...|:.       :.::....| .||...|||.        |..:...|.::....
  Rat   163 LKCAETWSLNGLVKHVLGKQLLKDKSIRCSNWSDFPLSEDQKLYAATDAYAGLIIYQKLENLGDA 227

  Fly   483 KQAAGKQKTTKPKAEPKPKTEKKAKVKAEKKPKAEKKPRNSKKAIAVEPAPDPEEDERQPLN--P 545
            .|.....     |||             |..|...||..||           ..|:.|...|  |
  Rat   228 VQVFALN-----KAE-------------ESLPMEMKKQLNS-----------ISEEMRDLANHFP 263

  Fly   546 EDLKYVLALEAGDITSVPRINVQDLEEADATAQRYIRTFAAGPNPGL----SEGSNIRVDEKRAA 606
            ...:.:..|:     .||.| ::::.|...:.::.|   .|..:.|.    ..||::...|..||
  Rat   264 VTCRNLETLQ-----RVPMI-LENISENLCSLRKVI---CASTDTGTKLEPGGGSHLLSSEGSAA 319

  Fly   607 ARKKLEERIAAGKLNENFVTINIQKKKFVRGKKSVNFSKYKKQQWRHKKRVAALSGPDMDMGGCD 671
            ..:| |:::...:                      .|.|.|::.|          .|::|
  Rat   320 VGEK-EKQMGEHR----------------------TFPKIKEEAW----------DPELD----- 346

  Fly   672 GGVLTCFQCGGVGHFAQQCK-VKG-------DSLLPLSAQLEEDPSPFPTLAE--AQEMASQGAV 726
                :..:...|..|.:|.| .||       ||||   .::.|.....|:::|  .|::..|...
  Rat   347 ----SLVKHEAVDVFRKQVKQEKGGFEDEMEDSLL---REVMERTCLMPSISEYDLQDLEQQAKE 404

  Fly   727 VAHSRNISRLPQAANAAILQGDELNESEEDDQESSGDEEVQQHPDPNWSSDEMDVDFEALDAAVE 791
            ..|           ||...|..|....::|:::||...|          ||| |::.|.|.:.
  Rat   405 EKH-----------NAISHQFSEHLSPDDDEKDSSYIIE----------SDE-DLEMEMLKSL-- 445

  Fly   792 ASLSQPVSQEKAASPIKTYVGHKIPEEFLKQAGLDTTASSSNRSQHGGVKPLYDLLPDGSVQDTT 856
            .:|:..|.:...:..::|.....:|.|.....|.:..........|        |||:.:.:.
  Rat   446 ENLNSDVGEPTHSKWLETGGSVNLPPEEEDGDGKEAFEEEQEEEDH--------LLPEPNAKQ-- 500

  Fly   857 PEVLEALH-MFGHTNFRKGQDRAIMRTL-SGLSSLVTLSTGSGKSLCYQLPAYLYSRKVGAITLV 919
               :..|. .|||.:|:..|.:.|...| ....::|.::||.|||||:|.|. :|:.|:|   :|
  Rat   501 ---INCLKTYFGHCSFKPVQWKVIHSVLEERRDNVVVMATGYGKSLCFQYPP-VYTGKIG---IV 558

  Fly   920 ISPLVSLMEDQV-----TGVPHFLRAHCLHTNQTAPQRMKIQQMIANGEIDILLVSPEAVVAGER 979
            ||||:|||||||     :.:|..|..        :.|...|...|..|...|:.::||.
  Rat   559 ISPLISLMEDQVLQLEMSNIPACLLG--------SAQPKNILGDIKLGRYRIIYITPEF------ 609

  Fly   980 ATGFGAILRQLPP---IAFACIDEAHCVSQWSHNFRPSYLMICKVLRKNLGVRTVLGLTATATLP 1041
            .:|...:|:||..   |....:|||||:|:|.|:||.|:..:.. |:..|.:..|:.|:|||:..
  Rat   610 CSGNLDLLQQLDSNIGITLIAVDEAHCISEWGHDFRSSFRTLGS-LKTALPLVPVIALSATASSS 673

  Fly  1042 TRVSIINHLGISDGE---RGIISDIPLPDNLVLSVSKDENRDAALLQLL-------NSERFEPCQ 1096
            .|..||..|.:.|..   .|.  |.|   ||.|.|   |.:...:||.|       .|..:|...
  Rat   674 IREDIIRCLNLKDPHITCTGF--DRP---NLYLEV---ERKTGNILQDLKPFLVRKTSSAWEFEG 730

  Fly  1097 SIIIYCTRRDECERIAGFIRTCVQDRREPTQDQTKKRKRVNWQAEPYHAGMPASRRRTVQKAFMS 1161
            ..||||..|...|::                  |.:..::|...:.|||||..|.|:.:...|:.
  Rat   731 PTIIYCPSRKVTEQV------------------TVELGKLNVACQAYHAGMKISERKDIHHRFLR 777

  Fly  1162 NELRIVVATIAFGMGINKPDIRAVIHYNMPRNFESYVQEIGRAGRDGLPSHCHLFLDAKGGDQSE 1226
            :|::.|||||||||||||.|||.||||..|:..|||.|||||||||||.|.||| |.|.....:.
  Rat   778 DEIQCVVATIAFGMGINKADIRKVIHYGAPKEMESYYQEIGRAGRDGLQSSCHL-LWAPADFNTT 841

  Fly  1227 LRR--HVYSNSIDRHVIRKL--LQKIFVPCSC----------DKEASKRTALPIPLE----GDGP 1273
            ..|  .:::.....|.::.:  ::|......|          ||...|.:...:..|    ...|
  Rat   842 RNRLIEIHNEKFRLHKLKMMVKMEKYLHSSRCRRQIILSHFEDKRLQKASLAVMGTEKCCDNCRP 906

  Fly  1274 RVHMC--------PGHEIG---FSVEKTVEMLD------IP------------------------ 1297
            |::.|        ...:.|   |.:...|::|.      ||
  Rat   907 RLNHCSSANNSEDTAQDFGPQAFQLLSAVDILQEKFGIKIPILFLRGSNSQRLPEKYHNHRLFGA 971

  Fly  1298 ----AENISTLLCYMELDPRWCISV-LSSAYVMAKVISYGGPKYLKHAAKECPPLAMAIALQIRD 1357
                ||:....|.:..:...:.:.| ..:.::....::..|.|:|..|..:.||   ::.||..:
  Rat   972 GKEQAESWWKALSHHLIAEGFLVEVPKQNKFIKTCSLTKKGRKWLGEAILQSPP---SLVLQADE 1033

  Fly  1358 KTF 1360
            :.|
  Rat  1034 EAF 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ4	NP_652607.1	RecQL4_SLD2_NTD	9..55	CDD:421279
RecQ4	NP_652607.1	RecQ	864..>1218	CDD:223588	138/373 (37%)
Wrn	XP_006253318.1	RNaseD_like	55..223	CDD:176650	33/184 (18%)
		recQ_fam	502..975	CDD:129701	158/518 (31%)
		DEAD	515..676	CDD:278688	60/179 (34%)
		HELICc	<730..832	CDD:238034	56/120 (47%)
		RecQ_Zn_bind	837..904	CDD:292742	8/66 (12%)
		RQC	923..1016	CDD:214936	12/92 (13%)
		HRDC	1118..1194	CDD:128635
		HTH_40	1226..1316	CDD:291179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820