Protein Alignment RecQ4 and rqh1

DIOPT Version :10

• Sequence 1: NP_652607.1
• Gene: RecQ4 / 53438
• FlyBaseID: FBgn0040290
• Length: 1579
• Species: Drosophila melanogaster
• Sequence 2: NP_593092.1
• Gene: rqh1 / 2541620
• PomBaseID: SPAC2G11.12
• Length: 1328
• Species: Schizosaccharomyces pombe
• Alignment Length: 1081
• Identity: 264/1081 - (24%)
• Similarity: 431/1081 - (39%)
• Gaps: 262/1081 - (24%)

  Fly   358 QTDMNSSMN----QKPDHL-NHTPP----------ASSQKSVAPKNKPPPSEQETDSDSDSVVAE 407
            :|::|..::    :.|..: |.|.|          .||...|...:.|..|:...|...|....:
pombe     5 KTNLNRHLDWFFRESPQKIENVTSPIKTLDFVKVKVSSSDIVVKDSIPHKSKNVFDDFDDGYAID 69

  Fly   408 SEEEQEPQEYRQLSKR-----------RKIVSTASGKVE----------VAAPVEIPNKVEPETE 451
            ..||.:......|..:           :||...||...|          .||.:|:....:|
pombe    70 LTEEHQSSSLNNLKWKDVEGPNILKPIKKIAVPASESEEDFDDVDEEMLRAAEMEVFQSCQP--- 131

  Fly   452 TFAQENPDFSADEDQDATYVPEN-----------KKKDKAKRKQAAGKQKTTKPKAEPKPKTEKK 505
             .|....|.:......::.||.:           |..|...|...:...|........||
pombe   132 -LAVNTADTTVSHSTSSSNVPRSLNKIHDPSRFIKDNDVENRIHVSSASKVASISNTSKP----- 190

  Fly   506 AKVKAEKKPKAEKKPRNSKKAIAVEPAPDPEEDERQPLNPEDLKYVLALEAGDITSVPRINVQD- 569
                   .|...:.| .|..::::|          .|:.|::|...|..        ||:|..:
pombe   191 -------NPIVSENP-ISATSVSIE----------IPIKPKELSNNLPF--------PRLNNNNT 229

  Fly   570 --------LEEADATAQRYIRTFAAGPNPGLSEGSNIRVDEKRAAARKKLEE----RIAAGKLNE 622
                    :|:.|          :|.|.|. |..|.|.:|......:..|:.    |....::::
pombe   230 NNNNDNNAIEKRD----------SASPTPS-SVSSQISIDFSTWPHQNLLQYLDILRDEKSEISD 283

  Fly   623 NFVTINIQKKKFVRGKKSVNFSKYKKQQWRHKK-----------RVAALSGPDMDMGGCDGGV-- 674
            ..:.: :::..|        .|::|  :|..|:           .|.:.:....:..|.:|.|
pombe   284 RIIEV-MERYPF--------SSRFK--EWIPKRDILSQKISSVLEVLSNNNNSNNNNGNNGTVPN 337

  Fly   675 -LTCFQCGGVGHFAQQCKVKGDSLLPLSAQLEEDPSPFPTLAEA--QEMASQGAVVAH---SRNI 733
             .|.|                   .|.|:..::.|.|...:.|:  :|.:::..|.:|   :..|
pombe   338 AKTFF-------------------TPPSSITQQVPFPSTIIPESTVKENSTRPYVNSHLVANDKI 383

  Fly   734 SRLPQAANAAI--LQGD-------ELNESEEDDQESSGDEEVQQHPDPNWSSDEMDVDFEALDAA 789
            :..|..:.|.:  ||.:       |.:|.:.||.:.:.:.....:.:...|||.:.:|.|..|
pombe   384 TATPFHSEAVVSPLQSNIRNSDIAEFDEFDIDDADFTFNTTDPINDESGASSDVVVIDDEEDD-- 446

  Fly   790 VEASLSQPVSQEKAASPIKTYVGHKIPEEFLKQAGLDTTASSSNRSQHGGVKPLYDLLPDGSVQD 854
            :|   ::|::|...||  |..|.:   ...|:.:.||.......:.::..|     |:|  |:.|
pombe   447 IE---NRPLNQALKAS--KAAVSN---ASLLQSSSLDRPLLGEMKDKNHKV-----LMP--SLDD 496

  Fly   855 T------TPEVLEAL-HMFGHTNFRKGQDRAIMRTLSGLSSLVTLSTGSGKSLCYQLPAYLYSRK 912
            .      :.|||..| |.|....|||.|..||..||||....:.:.||.||||||||||.:....
pombe   497 PMLSYPWSKEVLGCLKHKFHLKGFRKNQLEAINGTLSGKDVFILMPTGGGKSLCYQLPAVIEGGA 561

  Fly   913 VGAITLVISPLVSLMEDQVTGVPHFLRAHC----LHTNQTAPQRMKIQQ--MIANGEIDILLVSP 971
            ...:|||||||:|||:||   :.|..:.:.    |...|.|.:|.::..  |..|..:.:|.|:|
pombe   562 SRGVTLVISPLLSLMQDQ---LDHLRKLNIPSLPLSGEQPADERRQVISFLMAKNVLVKLLYVTP 623

  Fly   972 EAVVAGERATGFGAILRQLPP------IAFACIDEAHCVSQWSHNFRPSYLMICKVLRKNLGVRT 1030
            |.:.:.      |||.|.|..      :|...||||||||.|.|:|||.|..:..:..:..|: .
pombe   624 EGLASN------GAITRVLKSLYERKLLARIVIDEAHCVSHWGHDFRPDYKQLGLLRDRYQGI-P 681

  Fly  1031 VLGLTATATLPTRVSIINHLGISDGERGIISDIPLPDNLVLSVSKDENRDAALLQLLNSERFEPC 1095
            .:.|||||....:..|||.|.:.:... :.|....| ||...:...::....|.:.:::....
pombe   682 FMALTATANEIVKKDIINTLRMENCLE-LKSSFNRP-NLFYEIKPKKDLYTELYRFISNGHLH-- 742

  Fly  1096 QSIIIYCTRRDECERIAGFIRTCVQDRREPTQDQTKKRKRVNWQAEPYHAGMPASRRRTVQKAFM 1160
            :|.||||..|..||::|                 .|.|.....:|..||||:....|:.:|..:.
pombe   743 ESGIIYCLSRTSCEQVA-----------------AKLRNDYGLKAWHYHAGLEKVERQRIQNEWQ 790

  Fly  1161 SNELRIVVATIAFGMGINKPDIRAVIHYNMPRNFESYVQEIGRAGRDGLPSHCHLFLDAKGGDQS 1225
            |...:|:|||||||||::|.|:|.|||::.|::.|.|.||.|||||||.|:||.:|...|  |..
pombe   791 SGSYKIIVATIAFGMGVDKGDVRFVIHHSFPKSLEGYYQETGRAGRDGKPAHCIMFYSYK--DHV 853

  Fly  1226 ELRRHVYSNSID-------RHVIRKLLQKIFVPCSCDKEASKRTALPIPLEGDG-PRVHMCPGHE 1282
            ..::.:.|...|       |.::|:::|      .|:.:...|....:...|:. .:||...|.:
pombe   854 TFQKLIMSGDGDAETKERQRQMLRQVIQ------FCENKTDCRRKQVLAYFGENFDKVHCRKGCD 912

  Fly  1283 I-------------GFSVEKTVEMLDIPAENISTLLCYMEL 1310
            |             .||::....:..|..:  :|||..|::
pombe   913 ICCEEATYIKQDMTEFSLQAIKLLKSISGK--ATLLQLMDI 951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RecQ4	NP_652607.1	RecQL4_SLD2_NTD	9..55	CDD:412085
		RecQ	855..>1216	CDD:440280	136/379 (36%)
rqh1	NP_593092.1	RecQ	511..1007	CDD:440280	155/482 (32%)
		HRDC	1115..1195	CDD:128635