DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ4 and him-6

DIOPT Version :9

Sequence 1:	NP_652607.1	Gene:	RecQ4 / 53438	FlyBaseID:	FBgn0040290	Length:	1579	Species:	Drosophila melanogaster
Sequence 2:	NP_502390.2	Gene:	him-6 / 178201	WormBaseID:	WBGene00001865	Length:	988	Species:	Caenorhabditis elegans

Alignment Length:	660	Identity:	186/660 - (28%)
Similarity:	290/660 - (43%)	Gaps:	129/660 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   684 GHFA----QQCKVKGDSLL--PLSAQLEEDPSPFPTLAEAQEMASQGAVVAHSRNISRLPQAANA 742
            ||::    ||...:....|  |....|:|:| |...|.::.:....|              :.:.
Worm   101 GHYSFNEYQQFPSRPQKRLVDPPIVDLDEEP-PIVDLDDSFDNFHVG--------------STSE 150

  Fly   743 AILQGDELNESEEDDQESSGDEEVQQHPDPNWSSDEMDVDFEALDAAVEASLSQPVSQEKAASPI 807
            .::.||...|.||::...|.|                  |||::.|       ||.|:...||
Worm   151 EVVSGDIAPEEEEEEGHDSFD------------------DFESVPA-------QPPSKNTLAS-- 188

  Fly   808 KTYVGHKIPEEFLKQAGLDTTASSSNRSQHGGVKPLYDLLPDGSVQ----------DTTPEVLEA 862
                        |:::..:...:......||..:   ..|.|.|.:          |...|:.:.
Worm   189 ------------LQKSDSEIALNQQRHDMHGRFR---GFLQDDSEEFSDEVGLLGADMNKELYDT 238

  Fly   863 L-HMFGHTNFRKGQDRAIMRTLSGLSSLVTLSTGSGKSLCYQLPAYLYSRKVGAITLVISPLVSL 926
            | ..||...||..|.:.|:.||.|..:.|.:.||:||||||||||.:    :..:|:|:|||.||
Worm   239 LKSKFGFNQFRHRQKQCILSTLMGHDTFVLMPTGAGKSLCYQLPAVI----LPGVTVVVSPLRSL 299

  Fly   927 MEDQVTGVPHF-LRAHCLHTNQTAPQRMKIQQMIANG--EIDILLVSPEAVVAGERATGFGAILR 988
            :|||...:... :....|..:..||.:.||...:.:|  .|.:|.|:||.:.|..|.......|.
Worm   300 IEDQKMKMKELGIGCEALTADLGAPAQEKIYAELGSGNPSIKLLYVTPEKISASGRLNSVFFDLH 364

  Fly   989 QLPPIAFACIDEAHCVSQWSHNFRPSYLMICKVLRK--NLGVRTVLGLTATATLPTRVSIINHLG 1051
            :...:|...||||||||||.|:|||.|..:..:..|  |..| .::.||||||........:||.
Worm   365 RRGLLARFVIDEAHCVSQWGHDFRPDYTKLSSLREKYANPPV-PIIALTATATPKIVTDARDHLK 428

  Fly  1052 ISDGERGIISDIPLPDNLVLSVSKDENRDAALLQLLN----SERFEPCQSIIIYCTRRDECERIA 1112
            :.:.:..|.|.:  .|||     |.:....|...|:|    .::..|.:|.|:||..|.|||.:.
Worm   429 MQNSKLFISSFV--RDNL-----KYDLIPKAARSLINVVEKMKQLYPGKSGIVYCLSRKECETVQ 486

  Fly  1113 GFIRTCVQDRREPTQDQTKKRKRVNWQAEPYHAGMPASRRRTVQKAFMSNELRIVVATIAFGMGI 1177
            ..:                  .:....||.||||:..:.|.:||:::::|:..::.|||||||||
Worm   487 MML------------------TKAGLSAEVYHAGLNDNLRVSVQRSWIANKFDVICATIAFGMGI 533

  Fly  1178 NKPDIRAVIHYNMPRNFESYVQEIGRAGRDGLPSHCHLFLDAKGGDQSELRRHVYSNSIDRHV-- 1240
            :|||:|.||||::|::.|.|.||.|||||||:||:|.:.....  |...|||.:...:....|
Worm   534 DKPDVRFVIHYSLPKSIEGYYQETGRAGRDGMPSYCLMLYSYH--DSIRLRRMIEEGNTTTGVRS 596

  Fly  1241 --IRKLLQKIFVPCSCDKEASKRTALPIPLEGDGPRVHMCPGHEIGFSV-------EKTVEMLDI 1296
              :..:||   |...|:..:..|..:.:...|:......|...:....:       .:.:.:.|:
Worm   597 MHLNNVLQ---VVAYCENVSVCRRKMLVEHFGEVYDEQSCRNSKTPCDICERQRKNAEAIRLFDV 658

  Fly  1297 PAENISTLLC 1306
            ..:.:|.|.|
Worm   659 STDALSILKC 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ4	NP_652607.1	RecQL4_SLD2_NTD	9..55	CDD:421279
RecQ4	NP_652607.1	RecQ	864..>1218	CDD:223588	133/362 (37%)
him-6	NP_502390.2	RecQ	231..881	CDD:223588	151/473 (32%)
		DEAD	252..419	CDD:278688	67/171 (39%)
		HELICc	443..572	CDD:238034	57/151 (38%)
		RecQ_Zn_bind	577..643	CDD:292742	12/68 (18%)
		RQC	653..772	CDD:286470	4/16 (25%)
		HRDC	807..888	CDD:128635
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820