Protein Alignment RecQ4 and wrn-1

DIOPT Version :10

• Sequence 1: NP_652607.1
• Gene: RecQ4 / 53438
• FlyBaseID: FBgn0040290
• Length: 1579
• Species: Drosophila melanogaster
• Sequence 2: NP_495324.2
• Gene: wrn-1 / 174081
• WormBaseID: WBGene00006944
• Length: 1056
• Species: Caenorhabditis elegans
• Alignment Length: 885
• Identity: 223/885 - (25%)
• Similarity: 354/885 - (40%)
• Gaps: 263/885 - (29%)

  Fly   736 LPQAANAAILQGDELNESEEDDQESSGDEEVQQHPD-PNWSSDE-----MDVDFEALDAAVEASL 794
            ||.....::  .:||.|:|.:|.:...:.|.:...| |..:|::     .|.|:::.|..|
 Worm     8 LPSTRPGSV--NEELPETEPEDNDELPETEPESDSDKPTVTSNKTENQVADEDYDSFDDFV---- 66

  Fly   795 SQPVSQEKAASPIKTYVGHKIP--EEFLKQAGLDTTASSSNRSQHGG----------------VK 841
                       |.:|:...|||  .:..|:..:::.:|||:.|..|.                :|
 Worm    67 -----------PSQTHTASKIPVKNKRAKKCTVESDSSSSDDSDQGDDCEFIPACDETQEVPKIK 120

  Fly   842 PLYDLLPDGSVQD---------------------------------------------------- 854
            ..|.|....||::
 Worm   121 RGYTLRTRASVKNKCDDSWDDGIDEEDVSKRSEDTLNDSFVDPEFMDSVLDNQLTIKGKKQFLDD 185

  Fly   855 -----------------------TTP--EVLEALH-MFGHTNFRKGQDRAIMRTLSGLSSLVTLS 893
                                   |:|  |.|.||: .|||..||:.|...:...|.|....|.:|
 Worm   186 GEFFTDRNVPQIDEATKMKWASMTSPPQEALNALNEFFGHKGFREKQWDVVRNVLGGKDQFVLMS 250

  Fly   894 TGSGKSLCYQLPAYLYSRKVGAITLVISPLVSLMEDQVTG-VPHFLRAHCLHTNQTAPQRMKIQ- 956
            ||.|||:|||||:.|    :.::|:|:|||:|||.||||. |...:.|..|..:.|     :|:
 Worm   251 TGYGKSVCYQLPSLL----LNSMTVVVSPLISLMNDQVTTLVSKGIDAVKLDGHST-----QIEW 306

  Fly   957 QMIANG--EIDILLVSPEAVVAGERATGFGAILRQLPPIAFACIDEAHCVSQWSHNFRPSYLMIC 1019
            ..:||.  .|..:.:|||.|.:.:   |...:......|:...||||||||||.|:||.||..:.
 Worm   307 DQVANNMHRIRFIYMSPEMVTSQK---GLELLTSCRKHISLLAIDEAHCVSQWGHDFRNSYRHLA 368

  Fly  1020 KVL-RKNLGVRTVLGLTATATLPTRVSIINHLGISDGERGIISDIPLP-DNLVLSV--SKDENRD 1080
            ::. |.:|....::.||||||:..|..:|.:|.:   .:.:|:..... .||.:||  |||...|
 Worm   369 EIRNRSDLCNIPMIALTATATVRVRDDVIANLRL---RKPLITTTSFDRKNLYISVHSSKDMAED 430

  Fly  1081 AALLQLLNSERFE----PCQSIIIYCTRRDECERIAGFIRTCVQDRREPTQDQTKKRKRVNWQAE 1141
            ..|....:..:..    |   .||||..:...:.:     .||             .:|:..::.
 Worm   431 LGLFMKTDEVKGRHFGGP---TIIYCQTKQMVDDV-----NCV-------------LRRIGVRSA 474

  Fly  1142 PYHAGMPASRRRTVQKAFMSNELRIVVATIAFGMGINKPDIRAVIHYNMPRNFESYVQEIGRAGR 1206
            .||||:..::|......||.:::..:|||:||||||:|||:|.||||..|.|.|||.||||||||
 Worm   475 HYHAGLTKNQREKAHTDFMRDKITTIVATVAFGMGIDKPDVRNVIHYGCPNNIESYYQEIGRAGR 539

  Fly  1207 DGLPSHCHLFLDAKGGDQSELRRHVYSNSIDRHVIRKL------LQKIFVPCSCD-----KEASK 1260
            ||.||.|.:|...|  |.:.::..:.::.....|:..|      |:.:.....|.     |....
 Worm   540 DGSPSICRVFWAPK--DLNTIKFKLRNSQQKEEVVENLTMMLRQLELVLTTVGCRRYQLLKHFDP 602

  Fly  1261 RTALPIPLEGDGPRVHMCPGHEIGFSVEKTVEMLDIPAENISTLLCYMELDPRWCISVLSSAYVM 1325
            ..|.|..::.|      |        .::..|||:...::.|::: .:..:.:|...|::..|..
 Worm   603 SYAKPPTMQAD------C--------CDRCTEMLNGNQDSSSSIV-DVTTESKWLFQVINEMYNG 652

  Fly  1326 AKVISYGGP-KYLKHAAKE-------CPPLAMAIALQIRDKTFKEDSNIIEFSVTDIAAGI---G 1379
            ...|  |.| ::|:.::||       .......|...|.||.:|.           :||.:   |
 Worm   653 KTGI--GKPIEFLRGSSKEDWRIKTTSQQKLFGIGKHIPDKWWKA-----------LAASLRIAG 704

  Fly  1380 WNSGVVKYQLK--------DL--EW------VKVNGYP--------KRSPITVSFYDLGFRIKVP 1420
            :...|...|:|        :|  .|      :|::..|        |.:|.|           ||
 Worm   705 YLGEVRLMQMKFGSCITLSELGERWLLTGKEMKIDATPILLQGKKEKAAPST-----------VP 758

  Fly  1421 G----DFTESEIDNALDTLYTRSVKQ-----ERTQLIQLQ 1451
            |    ..|:|..:.....|....:::     |..||:.|:
 Worm   759 GASRSQSTKSSTEIPTKILGANKIREYEPANENEQLMNLK 798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RecQ4	NP_652607.1	RecQL4_SLD2_NTD	9..55	CDD:412085
		RecQ	855..>1216	CDD:440280	139/375 (37%)
wrn-1	NP_495324.2	RecQ	213..711	CDD:440280	171/563 (30%)
		HRDC	806..886	CDD:128635
		HTH_40	924..1003	CDD:464189