DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RecQ4 and recql5

DIOPT Version :9

Sequence 1:	NP_652607.1	Gene:	RecQ4 / 53438	FlyBaseID:	FBgn0040290	Length:	1579	Species:	Drosophila melanogaster
Sequence 2:	XP_031749855.1	Gene:	recql5 / 100216093	XenbaseID:	XB-GENE-958080	Length:	1071	Species:	Xenopus tropicalis

Alignment Length:	469	Identity:	153/469 - (32%)
Similarity:	226/469 - (48%)	Gaps:	92/469 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   824 GLDTTASSSNRSQHGGVKPLYDLLPDGSVQDTTPEVLEALHMFGHTNFRKG-QDRAIMRTLSGLS 887
            |.:..:|||:.|.....:|..      .:|.|...|      ||..:||.. |:.|....:.|.:
Frog    16 GTNKMSSSSSSSSSSSSRPRC------RIQTTLKNV------FGFNSFRSDLQENATRAVVKGET 68

  Fly   888 SL-VTLSTGSGKSLCYQLPAYLYSRKVGAITLVISPLVSLMEDQVTGVPHF----LRAHCLHTNQ 947
            .: |.:.||:||||||||||.|   .|| ||:|||||::|::||   |.|.    ::|..|::..
Frog    69 DVFVVMPTGAGKSLCYQLPAVL---SVG-ITVVISPLIALIQDQ---VDHLVALKIKACSLNSKL 126

  Fly   948 TAPQRMKIQQMIAN--GEIDILLVSPEAVVAGERATGFGAILRQL---PPIAFACIDEAHCVSQW 1007
            ..|:|.||.|.:.:  .:|.:|.::||...    :..|..||.||   ..:::..||||||||:|
Frog   127 PLPERKKIIQDLESEAPQIKLLYITPEMAA----SASFQPILAQLLSRSLLSYLIIDEAHCVSEW 187

  Fly  1008 SHNFRPSYLMICKVLRKNLGVRTVLGLTATATLPTRVSIINHLGISDGERGIISDIPLP---DNL 1069
            .|:|||.||.:.. ||..:.....:.||||||...:..||..|.:    |..:|....|   .||
Frog   188 GHDFRPDYLRLGS-LRSRIPHTPCVALTATATKQVQDDIIASLKL----RQPVSMFKTPCFRSNL 247

  Fly  1070 VLSVS-KDENRD------AALLQLLNSER----FEPCQSIIIYCTRRDECERIAGFIRTCVQDRR 1123
            ...|. ||...|      ...|:.|.::.    |..|.  |:||..||.||.:|
Frog   248 FYDVQLKDLVGDPYGDLKEFCLKALGTKTPQGGFPGCG--IVYCRTRDACEEVA----------- 299

  Fly  1124 EPTQDQTKKRKRVNWQAEPYHAGMPASRRRTVQKAFMSNELRIVVATIAFGMGINKPDIRAVIHY 1188
                .|..:|..:   ::|||||:.|..|.|:|..:|...:.::||||:||||::|.::|.|.|:
Frog   300 ----VQLSQRGVL---SKPYHAGLKAGDRVTIQNDWMDGTVPVIVATISFGMGVDKANVRFVAHW 357

  Fly  1189 NMPRNFESYVQEIGRAGRDGLPSHCHLFLDAKGGDQSELRRHVYSNSIDRHVIRKLLQKIFVPCS 1253
            |:.::...|.||.|||||||..:.|.|:               ||.: ||..:..|::|......
Frog   358 NIAKSLAGYYQESGRAGRDGKQAFCRLY---------------YSRT-DRDQVGFLIRKEIAQAQ 406

  Fly  1254 C---DKEASKRTAL 1264
            .   |.:||.:..:
Frog   407 AKRGDNKASDKAGM 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ4	NP_652607.1	RecQL4_SLD2_NTD	9..55	CDD:421279
RecQ4	NP_652607.1	RecQ	864..>1218	CDD:223588	135/378 (36%)
recql5	XP_031749855.1	RecQ	35..>462	CDD:223588	147/450 (33%)
recql5	XP_031749855.1	RecQ5	667..811	CDD:399738
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010