DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sulf1 and ARSJ

DIOPT Version :9

Sequence 1:	NP_001262626.1	Gene:	Sulf1 / 53437	FlyBaseID:	FBgn0040271	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_078866.3	Gene:	ARSJ / 79642	HGNCID:	26286	Length:	599	Species:	Homo sapiens

Alignment Length:	442	Identity:	101/442 - (22%)
Similarity:	164/442 - (37%)	Gaps:	117/442 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LIIGGL----ILLLFVLNVFSKEQGSHSHKR----SHSAKRFSRDSNSARERRPNIILILTDDQ- 64
            |.:|.|    ||.|......|..|.....:.    :.:.::....:.|..:  |::|.||.|||
Human    25 LAMGALAGFWILCLLTYGYLSWGQALEEEEEGALLAQAGEKLEPSTTSTSQ--PHLIFILADDQG 87

  Fly    65 --DVELGSLNFMPRTLRLLRDGGAEFRHAYTTTPMCCPARSSLLTGMY-VH---NHMVFTNN--- 120
              ||..........||..|...|.:..: |...|:|.|:||..:||.| :|   .|.:....
Human    88 FRDVGYHGSEIKTPTLDKLAAEGVKLEN-YYVQPICTPSRSQFITGKYQIHTGLQHSIIRPTQPN 151

  Fly   121 ----DNCSSPQWQATHETRSYATYLSNAGYRTGYFGK-YLNKYNGSYIPP--GWRE-WGGLIMNS 177
                ||.:.||            .|...||.|...|| :|..|....:|.  |:.. :|.|:.:.
Human   152 CLPLDNATLPQ------------KLKEVGYSTHMVGKWHLGFYRKECMPTRRGFDTFFGSLLGSG 204

  Fly   178 KYY-NYSINLNGQKIKHGFDYAKDYYPDLIANDSIAF-----LRSSKQQNQR-----------KP 225
            .|| :|..:..|.   .|:        ||..||:.|:     :.|::...||           ||
Human   205 DYYTHYKCDSPGM---CGY--------DLYENDNAAWDYDNGIYSTQMYTQRVQQILASHNPTKP 258

  Fly   226 VLLTMSFPAPHGPEDSAPQYSHLFFNVTTHHTPSYDHAPNPDKQWILRVTEPMQPVHKRFTNLLM 290
            :.|.:::.|.|.|..:..:|              ::|                   ::...|:..
Human   259 IFLYIAYQAVHSPLQAPGRY--------------FEH-------------------YRSIININR 290

  Fly   291 TKRLQTLQSVDVAVERVYNELKELGELDNTYIVYTSDHGYHLGQFGLIKGKSFP--------FEF 347
            .:....|..:|.|:..|...||..|..:|:.|:|:||:|   || ....|.::|        :|.
Human   291 RRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNG---GQ-PTAGGSNWPLRGSKGTYWEG 351

  Fly   348 DVRVPFLIRGPGIQ-ASKVVNEIVLNVDLAPTFLDM--GGVPTPQHMDGRSI 396
            .:|....:..|.:: ...|..|:|...|..||.:.:  |.:.....:||..|
Human   352 GIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYDI 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sulf1	NP_001262626.1	AslA	51..>398	CDD:225661	92/392 (23%)
		G6S	53..408	CDD:293766	92/390 (24%)
		DUF3740	640..790	CDD:289325
		ALP_like	<940..989	CDD:304875
ARSJ	NP_078866.3	4-S	76..509	CDD:293753	92/389 (24%)
		DUF4976	<495..>533	CDD:328073
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157210
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740