DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sulf1 and Galns

DIOPT Version :9

Sequence 1:	NP_001262626.1	Gene:	Sulf1 / 53437	FlyBaseID:	FBgn0040271	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_057931.3	Gene:	Galns / 50917	MGIID:	1355303	Length:	520	Species:	Mus musculus

Alignment Length:	515	Identity:	115/515 - (22%)
Similarity:	194/515 - (37%)	Gaps:	125/515 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PNIILILTDDQD-VELGSLNFMPR----TLRLLRDGGAEFRHAYTTTPMCCPARSSLLTGMYVHN 113
            |||:|:|.||.. .:|| :|..|.    .|..:...|..|...|:..|:|.|:|::||||.....
Mouse    28 PNIVLLLMDDMGWGDLG-VNGEPSRETPNLDRMAAEGMLFPSFYSANPLCSPSRAALLTGRLPIR 91

  Fly   114 HMVFTNN---DNCSSPQ---WQATHETRSYATYLSNAGYRTGYFGKYLNKYNGSYIP--PGWREW 170
            :..:|.|   .|..:||   ....:........|..|||.....||:...:...:.|  .|:.||
Mouse    92 NGFYTTNAHARNAYTPQEIMGGIPNSEHLLPELLKKAGYTNKIVGKWHLGHRPQFHPLKHGFDEW 156

  Fly   171 GGLIMNSKYYNYSINLNGQKIKHGFDYAKDY---------YP-----------DLIANDSIAFLR 215
            .| ..|..:..|.     .|.|......:|:         :|           .|...:::.|::
Mouse   157 FG-SPNCHFGPYD-----NKAKPNIPVYRDWEMVGRFYEEFPINRKTGEANLTQLYTQEALDFIQ 215

  Fly   216 SSKQQNQRKPVLLTMSFPAPHGPEDSAPQYSHLFFNVTTHHTPSYDHAPNPDKQWILRVTEPMQP 280
            :  |..::.|..|..:..|.|.|..::.|:      :.|.....|..|
Mouse   216 T--QHARQSPFFLYWAIDATHAPVYASRQF------LGTSLRGRYGDA----------------- 255

  Fly   281 VHKRFTNLLMTKRLQTLQSVDVAVERVYNELKELGELDNTYIVYTSDHGYHL-------GQFG-L 337
                            ::.:|.:|.::.:.|:.||...||::.:|||:|..|       |..| .
Mouse   256 ----------------VREIDDSVGKILSLLQNLGISKNTFVFFTSDNGAALISAPNEGGSNGPF 304

  Fly   338 IKGKSFPFEFDVRVPFLIRGPG-IQASKVVNEIVLNVDLAPTFLDMGGV--PTPQHMDGRSILPL 399
            :.||...||..:|.|.:...|| |.|.:|.:::...:||..|.|.:.|:  |:.:.:||..:||.
Mouse   305 LCGKQTTFEGGMREPAIAWWPGHIAAGQVSHQLGSIMDLFTTSLSLAGLKPPSDRVIDGLDLLPT 369

  Fly   400 LLSRNRAVRDNWPDSFLIESSGRRETAEQIAESRARLQIERRNMKLANSSLLEDFLEGA----GE 460
            :|      :....|..:....|....|..:.:.:|.|      ....||  .|:|.:|.    |:
Mouse   370 ML------KGQMMDRPIFYYRGNTLMAVTLGQYKAHL------WTWTNS--WEEFTQGTDFCPGQ 420

  Fly   461 S----TTIVSSSSTAATLMSSTAQQPEDGEE---EVETDNEEDDVDGDGAMDSSAAALEE 513
            :    ||......|...|:....:.|  ||.   ...:|..:|      |:..:...::|
Mouse   421 NVSGVTTHTQEEHTELPLIFHLGRDP--GERFPLSFHSDEYQD------ALSRTTQVVQE 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sulf1	NP_001262626.1	AslA	51..>398	CDD:225661	90/387 (23%)
		G6S	53..408	CDD:293766	93/397 (23%)
		DUF3740	640..790	CDD:289325
		ALP_like	<940..989	CDD:304875
Galns	NP_057931.3	Catalytic domain. /evidence=ECO:0000250	24..377		93/402 (23%)
		GALNS	27..492	CDD:293776	115/515 (22%)
		PRK13759	28..473	CDD:237491	115/515 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810