Protein Alignment Sulf1 and sulf2

DIOPT Version :10

• Sequence 1: NP_524987.1
• Gene: Sulf1 / 53437
• FlyBaseID: FBgn0040271
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_001005661.1
• Gene: sulf2 / 448151
• XenbaseID: XB-GENE-950465
• Length: 875
• Species: Xenopus tropicalis
• Alignment Length: 1082
• Identity: 390/1082 - (36%)
• Similarity: 526/1082 - (48%)
• Gaps: 278/1082 - (25%)

  Fly     1 MMRHSSLRLIIGGLILLLFVLNVFSKEQGSHSHKRSHSAKRFSRDSNSARERRPNIILILTDDQD 65
            ::..::|..|.|.|.||       ||::         ...||.||   .|..||||||:||||||
 Frog    11 LLTAAALLAIEGSLPLL-------SKQR---------MKGRFQRD---RRNIRPNIILVLTDDQD 56

  Fly    66 VELGSLNFMPRTLRLLRDGGAEFRHAYTTTPMCCPARSSLLTGMYVHNHMVFTNNDNCSSPQWQA 130
            |||||:..|.:|.|::..||..|.:|:.|||||||:|||:|||.|||||..:|||:|||||.|||
 Frog    57 VELGSMQVMNKTKRIMEQGGTHFINAFVTTPMCCPSRSSILTGKYVHNHNTYTNNENCSSPSWQA 121

  Fly   131 THETRSYATYLSNAGYRTGYFGKYLNKYNGSYIPPGWREWGGLIMNSKYYNYSINLNGQKIKHGF 195
            .|||.:::.||:|.||||.:||||||:|||:|:||||:||.||:.||::|||::..||.|.||||
 Frog   122 QHETHTFSVYLNNTGYRTAFFGKYLNEYNGTYVPPGWKEWVGLVKNSRFYNYTLCRNGIKEKHGF 186

  Fly   196 DYAKDYYPDLIANDSIAFLRSSKQQNQRKPVLLTMSFPAPHGPEDSAPQYSHLFFNVTTHHTPSY 260
            |||:||..|||.|:||.|.|:||:....:|||:.:|..|||||||||||||.:|.|.:.|.||||
 Frog   187 DYAQDYLTDLITNNSINFFRTSKKIYPHRPVLMVLSHVAPHGPEDSAPQYSQMFPNASQHITPSY 251

  Fly   261 DHAPNPDKQWILRVTEPMQPVHKRFTNLLMTKRLQTLQSVDVAVERVYNELKELGELDNTYIVYT 325
            ::||||||.||:|.|.||:|:|..|||:|..:|||||.|||.::|.:||.|.|.||::||||:||
 Frog   252 NYAPNPDKHWIMRYTGPMKPIHMEFTNMLQRRRLQTLMSVDSSMEMIYNMLVETGEVENTYIIYT 316

  Fly   326 SDHGYHLGQFGLIKGKSFPFEFDVRVPFLIRGPGIQASKVVNEIVLNVDLAPTFLDMGGVPTPQH 390
            :|||||:|||||:||||.|:|||:||||.||||.:.|..:...||||:|||||.||:.|:..|..
 Frog   317 ADHGYHIGQFGLVKGKSMPYEFDIRVPFYIRGPNVDAGSLNPHIVLNIDLAPTILDIAGLDIPPE 381

  Fly   391 MDGRSILPLLLSRNRAVRDN-------WPDSFLIESSGRRETAEQIAESRARLQIERRNMKLANS 448
            |||:|||.||.:.....|.:       |.||||:|              |.:|..:|
 Frog   382 MDGKSILKLLDTERPVNRFHIHKKVKVWRDSFLVE--------------RGKLLHKR-------- 424

  Fly   449 SLLEDFLEGAGESTTIVSSSSTAATLMSSTAQQPEDGEEEVETDNEEDDVDGDGAMDSSAAALEE 513
                                                         :.|.||.
 Frog   425 ---------------------------------------------DSDKVDA------------- 431

  Fly   514 DDLDDAAFEEGDEELDQEFQQNNDLPLAPYITKMMRLNSECSDPALLKNCLP-GQKWKCVNE-EG 576
                               |:.|.||      |..|:...|........|.. ||||:||.: .|
 Frog   432 -------------------QEENFLP------KYQRVKDLCQRAEYQTACEQLGQKWQCVEDPSG 471

  Fly   577 RWRKHKCK------FHLQLEHQLAAMPRKQYQRN---CACFTPDGVVYTKIRAPSAGLHR--VNK 630
            :.|.||||      ...|:..:...:....|..|   |.|   |.:.|   :.|..|..:  :.|
 Frog   472 KLRLHKCKGMAGLAATAQIRSKSPNLMSNYYSSNSDECNC---DSLSY---KIPPLGRRKKLLTK 530

  Fly   631 RTHNGPG-RRRNKREVFHTELPDEMEELLDLHQVVDQLVDHTHRSKRDLPASSNETIAQVIQQIQ 694
            :.:.... |.|:.|.|       .:|        ||..|             .|..|.|..|.|.
 Frog   531 KKYKASYLRNRSTRSV-------SIE--------VDGKV-------------FNLGIEQEYQPIM 567

  Fly   695 STLEILELKFNEHELHASNSSGNSYERGEKYTKSGG--------------HRCFVDATTAKVNCS 745
            ..|.         :.|.|....:..:..|.|:.:||              ||||:.|... |.|.
 Frog   568 RNLT---------KRHMSGLDDDEDKDMEDYSGTGGLTNDLIVPSSIKVTHRCFILANDT-VQCD 622

  Fly   746 NVIYDDEKTWRTSRTQIDMLIKLLKDKIGKLKEMKKQLRESNKQALAAGRRNDNRRRNDQSVLDS 810
            ..:|...:.|:..:..||..|:.|:.||..|:|::..|::...:
 Frog   623 MDLYKSLQAWKDHKVHIDHEIETLQSKIKNLREVRGHLKKKRPE--------------------- 666

  Fly   811 GAGPEFNMSYFTEISSTPRSNVVGQTEVFQGYGSASAFDSLEQTQSHRFTPRAECYCEPDVGENH 875
                |.|.|..:.|.:....:                    :.|..|.|
 Frog   667 ----ECNCSKISYIKNGKMKH--------------------KGTVMHPF---------------- 691

  Fly   876 ADSKEMAREARR--KLKEERQRKKERKRIKKARLEKECLSEKMNCFSHDNQHWRTAPLWNDSPFC 938
               |:..:|..:  .|:|:|.:||.||.:|:.|....|....:.||:||||||:|||.|...|||
 Frog   692 ---KKTLKEKDKVWLLREQRHKKKLRKLLKRLRNNDTCSMPGLTCFTHDNQHWQTAPFWTLGPFC 753

  Fly   939 FCMNANNNTYSCLRTINGTHNFLYCEFTTGLITFYNLTIDRFETINRAAGLTPGERSHMHDALDQ 1003
            .|.:||||||.||||||.|||||:|||.||.:.:::|..|.::.||....|.....:.:|..|.:
 Frog   754 ACTSANNNTYWCLRTINETHNFLFCEFATGFLEYFDLNTDPYQLINAVNTLDRDVLNQLHVQLME 818

  Fly  1004 LKSCRG-RSCSIRRHQNHL--EGGSSAPLLPINQVHRNNKRK 1042
            |:||:| |.|:.|.....|  :.||      ..|..:..:||
 Frog   819 LRSCKGYRQCNPRTRSLELGFKDGS------FEQYRQLQRRK 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sulf1	NP_524987.1	G6S	53..408	CDD:293766	219/354 (62%)
		DUF3740	637..793	CDD:463628	38/170 (22%)
		ALP_like	<940..989	CDD:474031	27/48 (56%)
sulf2	NP_001005661.1	G6S	44..386	CDD:293766	214/341 (63%)
		DUF3740	535..672	CDD:463628	40/199 (20%)
		ALP_like	<755..804	CDD:474031	27/48 (56%)