DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sulf1 and ARSD

DIOPT Version :9

Sequence 1:	NP_001262626.1	Gene:	Sulf1 / 53437	FlyBaseID:	FBgn0040271	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_001660.2	Gene:	ARSD / 414	HGNCID:	717	Length:	593	Species:	Homo sapiens

Alignment Length:	462	Identity:	103/462 - (22%)
Similarity:	167/462 - (36%)	Gaps:	155/462 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 DSNSARERRPNIILILTDDQDV-ELGSLNFMPRTLRL-----LRDGGAEFRHAYTTTPMCCPARS 103
            :..:|...:|||:||:.||... :||.  :...|||.     |.:.|..........|:|.|:|:
Human    32 EPKTANAFKPNILLIMADDLGTGDLGC--YGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRA 94

  Fly   104 SLLTGMYVHNHMVFTNNDNCSSPQWQA------THETRSYATYLSNAGYRTGYFGKYLNKYNGSY 162
            :.|||.:.....:..:| ...:.||.|      .:|| ::|..|...||.||..||
Human    95 AFLTGRHSFRSGMDASN-GYRALQWNAGSGGLPENET-TFARILQQHGYATGLIGK--------- 148

  Fly   163 IPPGWREWGGLIMNSKYYNYSINLNGQKIKHGFDYAKDYY--PDLIANDSIAFLRSSKQQNQRKP 225
                |.:.........:.::.:|       |||||   :|  |..:.||.          :..:|
Human   149 ----WHQGVNCASRGDHCHHPLN-------HGFDY---FYGMPFTLTNDC----------DPGRP 189

  Fly   226 VLLTMSFPAPHGPEDSAPQYSHL---------------------FFNVTTHHTP----------- 258
                        ||..|...:.|                     ||:|:.....
Human   190 ------------PEVDAALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLFFI 242

  Fly   259 ------------------SYDHAPNP---DKQWILRVTEPMQPV--HKRFTNLLMTKRL------ 294
                              ::|....|   :|...|.:.|.:..:  ||....||....|
Human   243 SWYSSFGFVRRWNCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSLLHVHIPL 307

  Fly   295 ----------------QTLQSVDVAVERVYNELKELGELDNTYIVYTSDHGYHL----------G 333
                            ..::.:|..:.:|.|.:::.|..::|:..:|||||.||          |
Human   308 VTTSAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGG 372

  Fly   334 QFGLIK-GKSF-PFEFDVRVPFLIRGPGI-QASKVVNEIVLNVDLAPTFLDM--GGVPTPQHMDG 393
            ..|:.| ||.. .:|..:|||.:...||: .|.:|:.|....:|:.||.:.:  |.||..:.:||
Human   373 WNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVIDG 437

  Fly   394 RSILPLL 400
            .|::|||
Human   438 HSLVPLL 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sulf1	NP_001262626.1	AslA	51..>398	CDD:225661	99/452 (22%)
		G6S	53..408	CDD:293766	102/454 (22%)
		DUF3740	640..790	CDD:289325
		ALP_like	<940..989	CDD:304875
ARSD	NP_001660.2	ALP_like	40..563	CDD:304875	102/454 (22%)
ARSD	NP_001660.2	AslA	40..525	CDD:225661	102/454 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157211
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740