DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sulf1 and ARSB

DIOPT Version :9

Sequence 1:	NP_001262626.1	Gene:	Sulf1 / 53437	FlyBaseID:	FBgn0040271	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_000037.2	Gene:	ARSB / 411	HGNCID:	714	Length:	533	Species:	Homo sapiens

Alignment Length:	386	Identity:	84/386 - (21%)
Similarity:	151/386 - (39%)	Gaps:	87/386 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SNSARERRPNIILILTDD---QDVELGSLNFMPRTLRLLRDGGAEFRHAYTTTPMCCPARSSLLT 107
            |.:...|.|:::.:|.||   .||...........|..|..||....: |.|.|:|.|:||.|||
Human    37 SGAGASRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDN-YYTQPLCTPSRSQLLT 100

  Fly   108 GMY-----VHNHMVFTNNDNCSSPQWQATHETRSYATYLSNAGYRTGYFGK-YLNKYNGSYIPP- 165
            |.|     :.:.:::....:|      ...:.:.....|..|||.|...|| :|..|....:|.
Human   101 GRYQIRTGLQHQIIWPCQPSC------VPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTR 159

  Fly   166 -GWREWGGLIMNSK-YYNY-------SINL--------NGQKIKHGFDYAKDYYPDLIANDSIAF 213
             |:..:.|.::.|: ||::       ::|:        :|:::..|  |...|..::....:||.
Human   160 RGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATG--YKNMYSTNIFTKRAIAL 222

  Fly   214 LRSSKQQNQRKPVLLTMSFPAPHGPEDSAPQYSHLFFNVTTHHTPSYDHAPNPDKQWILRVTEPM 278
            :.:...:   ||:.|.::..:.|.|           ..|...:...||...:.::.....:...|
Human   223 ITNHPPE---KPLFLYLALQSVHEP-----------LQVPEEYLKPYDFIQDKNRHHYAGMVSLM 273

  Fly   279 QPVHKRFTNLLMTKRLQTLQSVDVAVERVYNELKELGELDNTYIVYTSDHGYHLGQFGLIKGKSF 343
                                  |.||..|...||..|..:||..::::|:|   || .|..|.::
Human   274 ----------------------DEAVGNVTAALKSSGLWNNTVFIFSTDNG---GQ-TLAGGNNW 312

  Fly   344 P--------FEFDVRVPFLIRGPGIQASKVVNEIVLNV-DLAPTFLDM--GGVPTPQHMDG 393
            |        :|..||....:..|.::...|.|..:::: |..||.:.:  |.....:.:||
Human   313 PLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDG 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sulf1	NP_001262626.1	AslA	51..>398	CDD:225661	83/381 (22%)
		G6S	53..408	CDD:293766	82/379 (22%)
		DUF3740	640..790	CDD:289325
		ALP_like	<940..989	CDD:304875
ARSB	NP_000037.2	AslA	41..489	CDD:225661	83/382 (22%)
ARSB	NP_000037.2	4-S	45..488	CDD:293753	82/378 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810