Protein Alignment Sulf1 and sulf2a

DIOPT Version :10

• Sequence 1: NP_524987.1
• Gene: Sulf1 / 53437
• FlyBaseID: FBgn0040271
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: XP_005169326.2
• Gene: sulf2a / 393910
• ZFINID: ZDB-GENE-040426-759
• Length: 874
• Species: Danio rerio
• Alignment Length: 1075
• Identity: 383/1075 - (35%)
• Similarity: 517/1075 - (48%)
• Gaps: 275/1075 - (25%)

  Fly    15 ILLLFVLNVFSKEQGSHSHKRSHSAKRFSRDSNSARERRPNIILILTDDQDVELGSLNFMPRTLR 79
            :||:|:|.......||..........|..||   .|..|||:|||||||||:||||:..|.:|.|
Zfish    10 LLLVFILTFICLSDGSTYLSGQRQRSRLQRD---RRNVRPNMILILTDDQDIELGSMQAMNKTKR 71

  Fly    80 LLRDGGAEFRHAYTTTPMCCPARSSLLTGMYVHNHMVFTNNDNCSSPQWQATHETRSYATYLSNA 144
            ::..||..|.:|:.|||||||:||::|||.|||||..:|||:|||||.|||.||..::|.:|:|:
Zfish    72 IMMQGGTHFSNAFATTPMCCPSRSTILTGKYVHNHHTYTNNENCSSPSWQAHHEPHTFAVHLNNS 136

  Fly   145 GYRTGYFGKYLNKYNGSYIPPGWREWGGLIMNSKYYNYSINLNGQKIKHGFDYAKDYYPDLIAND 209
            ||||.:||||||:|||||:|||||||..|:.||::|||::..||.:.|||..|.|||..|:|.||
Zfish   137 GYRTAFFGKYLNEYNGSYVPPGWREWVALVKNSRFYNYTLCRNGIREKHGTQYPKDYLTDVITND 201

  Fly   210 SIAFLRSSKQQNQRKPVLLTMSFPAPHGPEDSAPQYSHLFFNVTTHHTPSYDHAPNPDKQWILRV 274
            ||.|.|.||:....:||::.:|..|||||||:|||||..|.|.:.|.||||:|||||||.||||.
Zfish   202 SINFFRMSKRMYPHRPVMMVLSHAAPHGPEDAAPQYSSAFPNASQHITPSYNHAPNPDKHWILRY 266

  Fly   275 TEPMQPVHKRFTNLLMTKRLQTLQSVDVAVERVYNELKELGELDNTYIVYTSDHGYHLGQFGLIK 339
            |.||:|||.:|||:|..:|||||.|||.:||:|||.|.|.||||||||:|.||||||:|||||:|
Zfish   267 TGPMKPVHMQFTNMLQRRRLQTLLSVDDSVEKVYNMLVETGELDNTYIIYMSDHGYHIGQFGLVK 331

  Fly   340 GKSFPFEFDVRVPFLIRGPGIQASKVVNEIVLNVDLAPTFLDMGGVPTPQHMDGRSILPLLLSR- 403
            |||.|:|||:|:||.:|||.::|..:...||||.|||||.|||.|:..||.|||:|||.||.:.
Zfish   332 GKSMPYEFDIRIPFYVRGPNVEAGAINPHIVLNTDLAPTLLDMAGIDIPQDMDGKSILKLLETER 396

  Fly   404 --NRAVRDN-------WPDSFLIESSGRRETAEQIAESRARLQIERRNMKLANSSLLEDFLEGAG 459
              |...|.:       |.||||:|   |.:...::|
Zfish   397 PVNSFTRFHSYKKAKLWRDSFLVE---RGKPLHKLA----------------------------- 429

  Fly   460 ESTTIVSSSSTAATLMSSTAQQPEDGEEEVETDNEEDDVDGDGAMDSSAAALEEDDLDDAAFEEG 524
                                    ||:|
Zfish   430 ------------------------DGKE------------------------------------- 433

  Fly   525 DEELDQEFQQNNDLPLAPYITKMMRLNSECSDPALLKNC-LPGQKWKCVNE-EGRWRKHKCK--F 585
                    .:.|.||      |..|:...|........| .|||||:|:.: .|..|.:|||  .
Zfish   434 --------VEQNSLP------KYQRVRDLCQRAEYQTPCEQPGQKWQCIEDGTGMPRLYKCKGMA 484

  Fly   586 HLQLEHQLAAMPRKQYQRN--------CACFTPDGVVYTKIRAPSAGLHRVNKRTHNGPGRRRNK 642
            .|.....|..|...:.|.:        |.|            .|:|.|.|....|..   :.:||
Zfish   485 GLYAPRALGLMAANRGQISAAHSGSDYCDC------------EPTASLKRKKALTKK---KLKNK 534

  Fly   643 REVFHTELPDEMEELLDLHQVVDQLVDHTHRSKRDLPASSNETIAQVIQQIQSTLEILELKFNEH 707
            :.|                        ..:|..|.:|.:.:..:        .||: ||..:...
Zfish   535 KSV------------------------PRNRWARSVPYNLDSNV--------YTLD-LEKGYRPL 566

  Fly   708 ELHASNSSGNS---YERGEKYTKSG-----------------GHRCFVDATTAKVNCSNVIYDDE 752
            .|:.|...|:.   |.:.|:|:..|                 .:||.: .....|.|...:|...
Zfish   567 NLNTSLMLGSKQAVYGQNEEYSGMGPTEDNFNSLTPPAALKVTYRCSI-LMNDTVKCDGGLYKSL 630

  Fly   753 KTWRTSRTQIDMLIKLLKDKIGKLKEMKKQLRESNKQALAAGRRNDNRRRNDQSVLDSGAGPEFN 817
            :.|:..:..|:..|:.|:.||..|:|:|..|:|...:.....:                     |
Zfish   631 QAWKDHKLHIEHEIETLQTKIKNLREVKGHLKEVRPKECECNK---------------------N 674

  Fly   818 MSYFTEISSTPRSNVVGQTEVFQGYGSASAFDSLEQTQSH---RFTPRAECYCEPDVGENHADSK 879
            |..:                      |:.|...|:..|:|   |.|.:              |.|
Zfish   675 MYQY----------------------SSRALFKLKSAQTHSVNRMTSK--------------DKK 703

  Fly   880 EMAREARRKLKEERQRKKERKRIKKARLEKECLSEKMNCFSHDNQHWRTAPLWNDSPFCFCMNAN 944
            :..      :||:::|||.||.:|:.|....|....:.||:||||||:|||.|...|||.|.:||
Zfish   704 QWL------MKEQKRRKKLRKLLKRLRNNDTCSMPGLTCFTHDNQHWQTAPFWTMGPFCACTSAN 762

  Fly   945 NNTYSCLRTINGTHNFLYCEFTTGLITFYNLTIDRFETINRAAGLTPGERSHMHDALDQLKSCRG 1009
            ||||.||||||.|||||:|||.||.:.:::|..|.::.:|..:.|.....:|||..|.:|:||:|
Zfish   763 NNTYWCLRTINETHNFLFCEFATGFLEYFDLNTDPYQLMNGVSTLDRDAVNHMHQQLMKLRSCKG 827

  Fly  1010 -RSCSIRRHQNHLEGGSSA-PLLPINQVHRNNKRK 1042
             :.|      |...||... .|.....:||..:.|
Zfish   828 HKEC------NQETGGKERNTLYDYRPLHRRKRPK 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sulf1	NP_524987.1	G6S	53..408	CDD:293766	220/357 (62%)
		DUF3740	637..793	CDD:463628	33/175 (19%)
		ALP_like	<940..989	CDD:474031	26/48 (54%)
sulf2a	XP_005169326.2	None