Protein Alignment Sulf1 and sulf1

DIOPT Version :10

• Sequence 1: NP_524987.1
• Gene: Sulf1 / 53437
• FlyBaseID: FBgn0040271
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_001003846.1
• Gene: sulf1 / 337298
• ZFINID: ZDB-GENE-030131-9242
• Length: 1099
• Species: Danio rerio
• Alignment Length: 1164
• Identity: 404/1164 - (34%)
• Similarity: 549/1164 - (47%)
• Gaps: 310/1164 - (26%)

  Fly    44 RDSNSARERRPNIILILTDDQDVELGSLNFMPRTLRLLRDGGAEFRHAYTTTPMCCPARSSLLTG 108
            |.....|..|||||||:|||||||||||..|.:|.:::.|||..|.:|:.|||||||:|||:|||
Zfish    32 RVQGDRRNIRPNIILIMTDDQDVELGSLQVMNKTRKIMEDGGTSFTNAFVTTPMCCPSRSSMLTG 96

  Fly   109 MYVHNHMVFTNNDNCSSPQWQATHETRSYATYLSNAGYRTGYFGKYLNKYNGSYIPPGWREWGGL 173
            .|||||..:|||:|||||.|||.||.||:|.||:|.||||.:||||||:|||||||||||||.||
Zfish    97 KYVHNHNTYTNNENCSSPSWQAQHEPRSFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWVGL 161

  Fly   174 IMNSKYYNYSINLNGQKIKHGFDYAKDYYPDLIANDSIAFLRSSKQQNQRKPVLLTMSFPAPHGP 238
            |.||::|||::..||.|.|||.||||||:.|||.||||.:.|:||:....:||::.:|..|||||
Zfish   162 IKNSRFYNYTVCRNGNKEKHGADYAKDYFTDLITNDSINYFRTSKRMFPHRPVMMVISHAAPHGP 226

  Fly   239 EDSAPQYSHLFFNVTTHHTPSYDHAPNPDKQWILRVTEPMQPVHKRFTNLLMTKRLQTLQSVDVA 303
            ||||||||.||.|.:.|.||||::|||.||.||::.|.||:|:|..|||.|..||||||.|||.:
Zfish   227 EDSAPQYSELFPNASQHITPSYNYAPNMDKHWIMQYTGPMKPIHMEFTNYLHRKRLQTLMSVDDS 291

  Fly   304 VERVYNELKELGELDNTYIVYTSDHGYHLGQFGLIKGKSFPFEFDVRVPFLIRGPGIQASKVVNE 368
            ||:|||.|.:.||||||||:||:|||||:|||||:||||.|::||:||||.:|||.::.....|.
Zfish   292 VEKVYNALVDTGELDNTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFVRGPNVEPGARNNH 356

  Fly   369 IVLNVDLAPTFLDMGGVPTPQHMDGRSILPLLLSRNRAVRDN-------WPDSFLIESSGRRETA 426
            :|||:|||||.||:.|:.||..|||:|||.||.......|..       |.|:||:|
Zfish   357 VVLNIDLAPTILDIAGLDTPPDMDGKSILKLLEQEKTGNRFKPNRKPKVWRDTFLVE-------- 413

  Fly   427 EQIAESRARLQIERRNMKLANSSLLEDFLEGAGESTTIVSSSSTAATLMSSTAQQPEDGEEEVET 491
                    |.:|.|:.                                        ||....:.|
Zfish   414 --------RGKILRKK----------------------------------------EDSASSLNT 430

  Fly   492 DNEEDDVDGDGAMDSSAAALEEDDLDDAAFEEGDEELDQEFQQNNDLPLAPYITKMMRLNSECSD 556
                                                     |.:|.||      |..::...|..
Zfish   431 -----------------------------------------QHSNSLP------KYKKVKEVCQQ 448

  Fly   557 PALLKNC-LPGQKWKCVNE-EGRWRKHKCKFHLQ--LEHQLAAMPRKQY---QRNCACFTPDGVV 614
            ......| .|||||.||.| .|:||..|||..|:  .:.:..::..:.|   :::|.|..
Zfish   449 AEFQTPCEQPGQKWHCVEEVSGKWRLQKCKGSLKEGSKKRTRSLRSRSYDNREKDCHCGE----- 508

  Fly   615 YTKIRAPSAGLHRVNKRTHNGPGRRRNKR---EVFHT----ELPDEME-ELLDLHQVVDQLVDHT 671
             ...:|..|.     :|.|...|:..|.|   ...||    .|..|.| |:.|:....|   |.|
Zfish   509 -RPYKAAKAA-----RRAHRQFGQSSNPRYRPRFVHTRPARSLSVEFEGEIYDVDLQAD---DKT 564

  Fly   672 HRSKRDLPASSNETIAQVIQQIQSTLEILELKFNEHELHASNSSGNSYERGEKYTKSGGHRCFVD 736
            ....|.:.....|..........     ||......|:.:.:::...|....|.|    |:||:
Zfish   565 PLEPRPISKRHYEPEPGFDSDFG-----LESDDGSEEMQSDDTNAVGYPNSLKVT----HKCFI- 619

  Fly   737 ATTAKVNCSNVIYDDEKTWRTSRTQIDMLIKLLKDKIGKLKEMKKQLRESNKQALAAGRRNDNRR 801
            .....|.|...||...:.|:..:..:|..|:.|:||:.||:|::..|:               ||
Zfish   620 LINDTVRCEREIYQSSRAWKDHKNFVDHEIEQLQDKMKKLREVRGHLK---------------RR 669

  Fly   802 RNDQSVLDSGAGPEFNMSYFTEISSTPRSNVVGQTEVFQGYGSASAFDSLEQTQSHRFTPRAECY 866
            |.|:....       ..|||                            |.|:.|.::
Zfish   670 RPDECDCS-------KKSYF----------------------------SKEREQKNK-------- 691

  Fly   867 CEPDVGENHADSKEMAREARRKL-------KEERQRKKERKRIKKARLEKECLSEKMNCFSHDNQ 924
              |:..:|..|.....:||.:::       .|.|:||||||..|:.:...:|....:.||:|:|.
Zfish   692 --PERLKNRNDHLHPFKEAMQEVDSKAQLYNEIRRRKKERKVRKRQKKGDDCSLPGLTCFTHNND 754

  Fly   925 HWRTAPLWNDSPFCFCMNANNNTYSCLRTINGTHNFLYCEFTTGLITFYNLTIDRFETINRAAGL 989
            ||:|||.||...||.|.::|||||.||||:|.|||.|:|||.||.:.:::|..|.::..|....:
Zfish   755 HWQTAPFWNLGGFCACTSSNNNTYWCLRTVNETHNTLFCEFATGFLEYFDLNSDPYQLTNAVYTV 819

  Fly   990 TPGERSHMHDALDQLKSCRG-RSCSIRRHQN---HLEGGSS-----------------APLLPIN 1033
            .....|.:|..|.:::||:| :.|:.|...:   |.:.|:|                 |.|..:|
Zfish   820 EKDILSQLHSQLMEMRSCQGHKQCNPRPRSSDAEHSQPGTSTKVKLPNFTEDVDWQGLADLYSMN 884

  Fly  1034 QVHRNNKRKHSPL----------------------------------------------AGA--V 1050
            :....::..:||:                                              ||:  :
Zfish   885 ESLYEHRHNYSPVLDDWMNFWKDVDSMFALLRNLKTLNQTDKLDPLVELGSGVLEEASGAGSLIL 949

  Fly  1051 GNYAFVGPRLDMEALPPIKRRKLSKYNRLTGSQQSHMKR-------RPWKQTPLQQSPR 1102
            .|.|..||.:|   |.|            ...|:||:|.       ||.|.:||   ||
Zfish   950 ENLATAGPSVD---LTP------------RTFQESHLKSLNELPEGRPTKVSPL---PR 990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sulf1	NP_524987.1	G6S	53..408	CDD:293766	226/354 (64%)
		DUF3740	637..793	CDD:463628	38/163 (23%)
		ALP_like	<940..989	CDD:474031	23/48 (48%)
sulf1	NP_001003846.1	G6S	41..383	CDD:293766	221/341 (65%)
		DUF3740	533..678	CDD:463628	39/179 (22%)
		ALP_like	<770..819	CDD:474031	23/48 (48%)