DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sulf1 and Sgsh

DIOPT Version :9

Sequence 1:	NP_001262626.1	Gene:	Sulf1 / 53437	FlyBaseID:	FBgn0040271	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_061292.2	Gene:	Sgsh / 27029	MGIID:	1350341	Length:	502	Species:	Mus musculus

Alignment Length:	460	Identity:	99/460 - (21%)
Similarity:	169/460 - (36%)	Gaps:	109/460 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLFVLNVFSKEQGSHSHKRSHSAKRFSRDSNSARERRPNIILILTDDQDVELGSLN---FMPRTL 78
            :|.||.:.    |:||.                     |::||:.||...|.|..|   .....|
Mouse    11 ILLVLGLC----GAHSR---------------------NVLLIVADDGGFESGVYNNTAIATPHL 50

  Fly    79 RLLRDGGAEFRHAYTTTPMCCPARSSLLTGMYVHNHMVFTNNDNCSSPQWQATHETRSYATYLSN 143
            ..|......||:|:|:...|.|:|:|||||:..|.:.::..:.:..  .:.:..:.:|....|:.
Mouse    51 DALSRHSLIFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVH--HFNSFDKVQSLPLLLNQ 113

  Fly   144 AGYRTGYFGKYLNKYNGSYIPP--------GWREWGGLIMNSKYYNYSINLNGQKIKHGFDYAKD 200
            ||.|||..||       .::.|        .:.|....:|       .:..|..:||.
Mouse   114 AGVRTGIIGK-------KHVGPETVYPFDFAFTEENSSVM-------QVGRNITRIKQ------- 157

  Fly   201 YYPDLIANDSIAFLRSSKQQNQRKPVLLTMSFPAPHGPEDSAPQYSHLFFNVTTHHTPSYDHAPN 265
                        .::...|....:|..|.::|..||....|.|||. .|.....:......:.|:
Mouse   158 ------------LVQKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYG-TFCEKFGNGESGMGYIPD 209

  Fly   266 PDKQWILRVTEPMQPVHKRF------TNLLMTKRLQTLQSVDVAVERVYNELKELGELDNTYIVY 324
                |..::.:|...:...|      ....:..:..|:..:|..|..|..||:..|.|::|.|::
Mouse   210 ----WTPQIYDPQDVMVPYFVPDTPAARADLAAQYTTIGRMDQGVGLVLQELRGAGVLNDTLIIF 270

  Fly   325 TSDHGYHLGQFGLIKGKSFPFEFDVRVPFLIRGP--GIQASKVVNEIVLNVDLAPTFLDMGGVPT 387
            |||:|     .....|::..:......|.|:..|  ..:..:|.:..|..:||.||.||...:|.
Mouse   271 TSDNG-----IPFPSGRTNLYWPGTAEPLLVSSPEHPQRWGQVSDAYVSLLDLTPTILDWFSIPY 330

  Fly   388 PQH---------MDGRSILPLLLSRNRAVRDNWPDSFLIESSGRRETAEQIAESRARLQIERRNM 443
            |.:         :.|||:||.|     .....|...|..:|.      .::..|.....:..:|.
Mouse   331 PSYAIFGSKTIQLTGRSLLPAL-----EAEPLWATVFSSQSH------HEVTMSYPMRSVYHQNF 384

  Fly   444 KLANS 448
            :|.::
Mouse   385 RLIHN 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sulf1	NP_001262626.1	AslA	51..>398	CDD:225661	84/374 (22%)
		G6S	53..408	CDD:293766	87/382 (23%)
		DUF3740	640..790	CDD:289325
		ALP_like	<940..989	CDD:304875
Sgsh	NP_061292.2	AslA	20..464	CDD:225661	95/447 (21%)
Sgsh	NP_061292.2	SGSH	24..472	CDD:293751	93/422 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810